NurOwn™: mesenchymal stem cells secreting neurotrophic factors. An autologous cell therapy in clinical trials for ALS

Introduction. An increase in patients with diabetes and a large number of amputations of limbs make the search for new treatments for these patients. Materials and methods. The study included 17 patients with complicated forms of diabetes. Patients were studied in the bone marrow immediately after surgery - the amputation of the limb. The number of hematopoietic stem cells and mesenchymal stem cells using specific markers were determined in the laboratory. The immunohistochemical characteristics of bone marrow were carried out for all samples. Results and conclusion. The obtained results indicate the biological value of bone marrow removed with amputation of the lower limb of the patient with complicated diabetes mellitus. The ease of obtaining bone marrow makes the procedure approachable in surgical practice. The presence of hematopoietic and mesenchymal stem cells provides the opportunity to use them in autologous cell therapy for patient.

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<i>In Pursuit</i> of Porcine Pluripotent Stem Cells for Autologous Cell Therapy

Stem Cell Discovery ◽

10.4236/scd.2014.44012 ◽

2014 ◽

Vol 04 (04) ◽

pp. 107-124 ◽

Cited By ~ 1

Author(s):

Vinod Verma ◽

Ashish Mehta ◽

Sanjay Pal ◽

Manoj Kumar ◽

Birbal Singh ◽

...

Keyword(s):

Stem Cells ◽

Cell Therapy ◽

Pluripotent Stem Cells ◽

Autologous Cell ◽

Autologous Cell Therapy

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A novel sub-population of bone marrow–derived myocardial stem cells: potential autologous cell therapy in myocardial infarction

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2003.08.007 ◽

2004 ◽

Vol 23 (7) ◽

pp. 873-880 ◽

Cited By ~ 9

Author(s):

Harmik J. Soukiasian ◽

Lawrence S.C. Czer ◽

Itzhak Avital ◽

Takeshi Aoki ◽

Yong-Hwan Kim ◽

...

Keyword(s):

Myocardial Infarction ◽

Stem Cells ◽

Bone Marrow ◽

Cell Therapy ◽

Autologous Cell ◽

Autologous Cell Therapy

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Update on clinical trials with autologous bone marrow-derived mesenchymal stem cells secreting neurotrophic factors (MSC-NTF) in patients with amyotrophic lateral sclerosis (ALS)

Cytotherapy ◽

10.1016/j.jcyt.2015.03.434 ◽

2015 ◽

Vol 17 (6) ◽

pp. S38-S39 ◽

Cited By ~ 2

Author(s):

Yael Gothelf ◽

Panayota Petrou ◽

Marc Gotkine ◽

Adi Vaknin-Dembinsky ◽

Yossef Levy ◽

...

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Clinical Trials ◽

Amyotrophic Lateral Sclerosis ◽

Mesenchymal Stem Cells ◽

Neurotrophic Factors ◽

Autologous Bone Marrow ◽

Autologous Bone ◽

Lateral Sclerosis

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Stem Cell Therapy: A Promising Approach in Treatment of COVID 19

Current Stem Cell Research & Therapy ◽

10.2174/1574888x15666201012165700 ◽

2020 ◽

Vol 15 ◽

Author(s):

Bahareh Abbaspanah ◽

Saeid Abroun ◽

Morteza Zarrabi ◽

Ashkan Mozdgir ◽

Mohammad Mollanouri

Keyword(s):

Stem Cells ◽

Clinical Trials ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Global Health ◽

Clinical Outcome ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Antiviral Treatment ◽

Health Crisis

: COVID-19 pandemic is a global health crisis in the 21st Century. There are currently no approved vaccine and no particular antiviral treatment for coronavirus disease. As COVID-19 has had a broad range of illnesses, it is necessary to find a safe and effective therapeutic method for COVID-19. An attractive approach for treating COVID-19 is cell therapy. Cell therapy aims to inject new and healthy stem cells into a patient’s body, to repair the damaged cells and tissues. Stem cell therapy is one of the most studied and important approaches in treatment of COVID-19 these days. The significant clinical outcome was observed by the adoptive transfer of stem cells, specifically mesenchymal stem cells. This study reviews the characteristics of stem cells and clinical trials which uses stem cells in treating COVID-19.

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