Tailored-interpenetrating polymer network beads of κ-carrageenan and sodium carboxymethyl cellulose for controlled drug delivery

2016 ◽  
Vol 31 ◽  
pp. 53-64 ◽  
Author(s):  
Alka Lohani ◽  
Garima Singh ◽  
Shiv Sankar Bhattacharya ◽  
Rahul Rama Hegde ◽  
Anurag Verma
Keyword(s):  
Drug Delivery ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Delivery ◽  
Interpenetrating Polymer Network ◽  
Sodium Carboxymethyl Cellulose

scholarly journals pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3197
Author(s):  
Younghyun Shin ◽  
Dajung Kim ◽  
Yiluo Hu ◽  
Yohan Kim ◽  
In Ki Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Hek 293 ◽  
Natural Polysaccharide ◽  
293 Cells

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

Semi-interpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of ketorolac tromethamine

2006 ◽  
Vol 65 (3) ◽  
pp. 243-252 ◽  
Author(s):  
Ajit P. Rokhade ◽  
Sunil A. Agnihotri ◽  
Sangamesh A. Patil ◽  
Nadagouda N. Mallikarjuna ◽  
Padmakar V. Kulkarni ◽  
...  
Keyword(s):  
Controlled Release ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Sodium Carboxymethyl Cellulose ◽  
Ketorolac Tromethamine

Fabrication and characterization of a novel semi-interpenetrating network hydrogel based on sodium carboxymethyl cellulose and poly(methacrylic acid) for oral insulin delivery

2020 ◽  
Vol 35 (1) ◽  
pp. 3-14
Author(s):  
Shunying Li ◽  
Zhiru Chen ◽  
Jun Wang ◽  
Libiao Yan ◽  
Tingting Chen ◽  
...  
Keyword(s):  
Oral Administration ◽  
Methacrylic Acid ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Insulin Delivery ◽  
Interpenetrating Polymer Network ◽  
Sodium Carboxymethyl Cellulose ◽  
Oral Insulin ◽  
Swelling Properties

In this research, pH-sensitive semi-interpenetrating polymer network hydrogels based on sodium carboxymethyl cellulose and poly(methacrylic acid) were synthesized using free radical polymerization and semi-interpenetrating polymer network approach for oral administration of insulin. The chemical structure and thermal stability of the hydrogels were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis measurements. The interior morphology was observed by scanning electron microscopy and the inner structure exhibited a porous honeycomb-like shape. The investigations on the swelling properties of hydrogels revealed their ability to response to pH value change. The in vitro release behavior of insulin was pH dependent and the release of insulin was much lower at pH 1.2 compared to pH 6.8. In vitro cytotoxicity assay indicated that the hydrogels were noncytotoxic to HeLa cells. A sustained reduction in blood glucose level was observed after oral administration of insulin-loaded hydrogel to diabetic rats at 75 IU/kg. These results indicated that the hydrogel would be a promising vehicle for oral insulin delivery systems.

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