Thiolated chitosan nanoparticles for augmented oral bioavailability of gemcitabine: Preparation, optimization, in vitro and in vivo study

2020 ◽  
pp. 102169
Author(s):  
Amandeep Kaur ◽  
Parveen Kumar ◽  
Loveneet Kaur ◽  
Rohit Sharma ◽  
Preeti Kush
Keyword(s):  
Oral Bioavailability ◽  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Thiolated Chitosan

scholarly journals Atorvastatin calcium loaded chitosan nanoparticles: in vitro evaluation and in vivo pharmacokinetic studies in rabbits

2015 ◽  
Vol 51 (2) ◽  
pp. 467-477 ◽  
Author(s):  
Abdul Baquee Ahmed ◽  
Ranjit Konwar ◽  
Rupa Sengupta
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Oral Bioavailability ◽  
Chitosan Nanoparticles ◽  
Rabbit Model ◽  
Pharmacokinetic Studies ◽  
Release Formulation ◽  
Atorvastatin Calcium

<p>In this study, we prepared atorvastatin calcium (AVST) loaded chitosan nanoparticles to improve the oral bioavailability of the drug. Nanoparticles were prepared by solvent evaporation technique and evaluated for its particle size, entrapment efficiency, zeta potential, <italic>in vitro</italic> release and surface morphology by scanning electron microscopy (SEM). In addition, the pharmacokinetics of AVST from the optimized formulation (FT5) was compared with marketed immediate release formulation (Atorva<sup>(r))</sup> in rabbits. Particle size of prepared nanoparticles was ranged between 179.3 ± 7.12 to 256.8 ± 8.24 nm with a low polydispersity index (PI) value. Zeta potential study showed that the particles are stable with positive values between 13.03 ± 0.32 to 46.90 ± 0.49 mV. FT-IR studies confirmed the absence of incompatibility of AVST with excipient used in the formulations. <italic>In vitro</italic> release study showed that the drug release was sustained for 48 h. Results of pharmacokinetics study showed significant changes in the pharmacokinetic parameter (2.2 fold increase in AUC) of the optimized formulation as compared to marketed formulation (Atorva<sup>(r))</sup>. Thus, the developed nanoparticles evidenced the improvement of oral bioavailability of AVST in rabbit model.</p>

scholarly journals Chitosan Nanoparticles of 5-Fluorouracil for Ophthalmic Delivery: Characterization, in-Vitro and in-Vivo Study

2011 ◽  
Vol 59 (2) ◽  
pp. 272-278 ◽  
Author(s):  
Ramesh Chand Nagarwal ◽  
Paras Nath Singh ◽  
Shri Kant ◽  
Pralay Maiti ◽  
Jayanta Kumar Pandit
Keyword(s):  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Ophthalmic Delivery

The effect of nanonization on poorly water soluble glibenclamide using a liquid anti-solvent precipitation technique: aqueous solubility, in vitro and in vivo study

RSC Advances ◽  
2015 ◽  
Vol 5 (99) ◽  
pp. 81728-81738 ◽  
Author(s):  
Rohan D. Deshpande ◽  
Gowda D. V. ◽  
Naga Sravan Kumar Varma Vegesna ◽  
Rudra Vaghela ◽  
Kulkarni P. K.
Keyword(s):  
Process Parameters ◽  
Oral Bioavailability ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
In Vivo Study ◽  
Precipitation Technique ◽  
Poorly Water Soluble

In the present study, efforts were made to optimize the process parameters of LAS technique for developing GLB NPs, in order to enhance the aqueous solubility as well as oral bioavailability.

Ellagic acid-loaded, tween 80-coated, chitosan nanoparticles as a promising therapeutic approach against breast cancer: In-vitro and in-vivo study

Life Sciences ◽  
2021 ◽  
pp. 119927
Author(s):  
Harsheen Kaur ◽  
Sandip Ghosh ◽  
Pradeep Kumar ◽  
Biswarup Basu ◽  
Kalpana Nagpal
Keyword(s):  
Breast Cancer ◽  
Ellagic Acid ◽  
Therapeutic Approach ◽  
Chitosan Nanoparticles ◽  
Tween 80 ◽  
In Vivo Study ◽  
Promising Therapeutic Approach

scholarly journals Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Shahrooz Saremi ◽  
Rassoul Dinarvand ◽  
Abbas Kebriaeezadeh ◽  
Seyed Nasser Ostad ◽  
Fatemeh Atyabi
Keyword(s):  
Oral Bioavailability ◽  
Oral Drug Delivery ◽  
Drug Loading ◽  
Cell Monolayer ◽  
Chitosan Nanoparticles ◽  
Positive Control ◽  
In Vivo Studies ◽  
Oral Drug ◽  
Thiolated Chitosan

The aim of this study was to evaluate a nanoparticulate system with mucoadhesion properties composed of a core of polymethyl methacrylate surrounded by a shell of thiolated chitosan (Ch-GSH-pMMA) for enhancing oral bioavailability of docetaxel (DTX), an anticancer drug. DTX-loaded nanoparticles were prepared by emulsion polymerization method using cerium ammonium nitrate as an initiator. Physicochemical properties of the nanoparticles such as particle size, size distribution, morphology, drug loading, and entrapment efficiency were characterized. The pharmacokinetic study was carried out in vivo using wistar rats. The half-life of DTX-loaded NPs was about 9 times longer than oral DTX used as positive control. The oral bioavailability of DTX was increased to 68.9% for DTX-loaded nanoparticles compared to 6.5% for positive control. The nanoparticles showed stronger effect on the reduction of the transepithelial electrical resistance (TEER) of Caco-2 cell monolayer by opening the tight junctions. According to apparent permeability coefficient (Papp) results, the DTX-loaded NPs showed more specific permeation across the Caco-2 cell monolayer in comparison to the DTX. In conclusion, the nanoparticles prepared in this study showed promising results for the development of an oral drug delivery system for anticancer drugs.

pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation

Drug Delivery ◽  
2014 ◽  
Vol 23 (1) ◽  
pp. 238-247 ◽  
Author(s):  
Bo Fan ◽  
Yang Xing ◽  
Ying Zheng ◽  
Chuan Sun ◽  
Guixian Liang
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Chitosan Nanoparticles ◽  
Low Molecular Weight ◽  
Ph Responsive ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan

In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery

2008 ◽  
Vol 349 (1-2) ◽  
pp. 226-233 ◽  
Author(s):  
Fu Chen ◽  
Zhi-Rong Zhang ◽  
Fang Yuan ◽  
Xuan Qin ◽  
Minting Wang ◽  
...  
Keyword(s):  
Protein Delivery ◽  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Trimethyl Chitosan ◽  
Oral Protein Delivery

In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats model

2018 ◽  
Vol 117 ◽  
pp. 601-609 ◽  
Author(s):  
Arian Ehterami ◽  
Majid Salehi ◽  
Saeed Farzamfar ◽  
Ahmad Vaez ◽  
Hadi Samadian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound
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