scholarly journals Chitosan Nanoparticles of 5-Fluorouracil for Ophthalmic Delivery: Characterization, in-Vitro and in-Vivo Study

2011 ◽  
Vol 59 (2) ◽  
pp. 272-278 ◽  
Author(s):  
Ramesh Chand Nagarwal ◽  
Paras Nath Singh ◽  
Shri Kant ◽  
Pralay Maiti ◽  
Jayanta Kumar Pandit
Keyword(s):  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Ophthalmic Delivery

Thiolated chitosan nanoparticles for augmented oral bioavailability of gemcitabine: Preparation, optimization, in vitro and in vivo study

2020 ◽  
pp. 102169
Author(s):  
Amandeep Kaur ◽  
Parveen Kumar ◽  
Loveneet Kaur ◽  
Rohit Sharma ◽  
Preeti Kush
Keyword(s):  
Oral Bioavailability ◽  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Thiolated Chitosan

Ellagic acid-loaded, tween 80-coated, chitosan nanoparticles as a promising therapeutic approach against breast cancer: In-vitro and in-vivo study

Life Sciences ◽  
2021 ◽  
pp. 119927
Author(s):  
Harsheen Kaur ◽  
Sandip Ghosh ◽  
Pradeep Kumar ◽  
Biswarup Basu ◽  
Kalpana Nagpal
Keyword(s):  
Breast Cancer ◽  
Ellagic Acid ◽  
Therapeutic Approach ◽  
Chitosan Nanoparticles ◽  
Tween 80 ◽  
In Vivo Study ◽  
Promising Therapeutic Approach

In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery

2008 ◽  
Vol 349 (1-2) ◽  
pp. 226-233 ◽  
Author(s):  
Fu Chen ◽  
Zhi-Rong Zhang ◽  
Fang Yuan ◽  
Xuan Qin ◽  
Minting Wang ◽  
...  
Keyword(s):  
Protein Delivery ◽  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Trimethyl Chitosan ◽  
Oral Protein Delivery

In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats model

2018 ◽  
Vol 117 ◽  
pp. 601-609 ◽  
Author(s):  
Arian Ehterami ◽  
Majid Salehi ◽  
Saeed Farzamfar ◽  
Ahmad Vaez ◽  
Hadi Samadian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Chitosan Nanoparticles ◽  
In Vivo Study ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

scholarly journals Efficiency of GnRH–Loaded Chitosan Nanoparticles for Inducing LH Secretion and Fertile Ovulations in Protocols for Artificial Insemination in Rabbit Does

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 440
Author(s):  
Eman M. Hassanein ◽  
Nesrein M. Hashem ◽  
Kheir El-Din M. El-Azrak ◽  
Antonio Gonzalez-Bulnes ◽  
Gamal A. Hassan ◽  
...  
Keyword(s):  
Artificial Insemination ◽  
Chitosan Nanoparticles ◽  
In Vitro Study ◽  
Ovarian Response ◽  
In Vivo Study ◽  
Control Group ◽  
Lh Surge ◽  
Routes Of Administration

Gonadotropin-releasing hormone (GnRH)–loaded chitosan nanoparticles (GnRH–ChNPs) were used at different doses and routes of administration to induce ovulation in rabbits as an attempt to improve artificial insemination (AI) procedures and outcomes. In this study, the characteristics (size, polydispersity, loading efficiency, and zeta-potential) of GnRH–ChNPs and the GnRH release pattern were determined in an in vitro study. A first in vivo study assessed the pituitary and ovarian response to different GnRH–ChNPs doses and routes of administration (two i.m. doses, Group HM = 0.4 µg and Group QM = 0.2 µg, and two intravaginal doses, Group HV = 4 µg and Group QV = 2 µg) against a control group (C) receiving bare GnRH (0.8 µg). The HM, QM, and HV treatments induced an earlier LH-surge (90 min) than that observed in group C (120 min), whilst the QV treatment failed to induce such LH surge. The number of ovulation points was similar among treatments, except for the QV treatment (no ovulation points). A second in vivo study was consequently developed to determine the hormonal (progesterone, P4, and estradiol, E2) profile and pregnancy outcomes of both HM and HV treatments against group C. The treatment HM, but not the treatment HV, showed adequate P4 and E2 concentrations, conception and parturition rates, litter size, litter weight, and viability rate at birth. Overall, the use of GnRH–ChNPs allows for a reduction in the conventional intramuscular GnRH dose to half without compromising fertility. However, the addition of GnRH–ChNPs to semen extenders, although successfully inducing ovulation, has negative impacts on fertility. Thus, more studies are needed to explore this point and allow further adjustments.

Biological effect of Egyptian Propolis on BHK cell line and on dental pulp tissue (An In vitro And In vivo study)

2018 ◽  
Vol 64 (3) ◽  
pp. 2161-2170
Author(s):  
Marwa Moussa ◽  
Marwa Temirek
Keyword(s):  
Cell Line ◽  
Dental Pulp ◽  
Biological Effect ◽  
In Vivo Study ◽  
Pulp Tissue ◽  
Dental Pulp Tissue
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