Design, development and QbD based optimization of double coated spheronized aceclofenac pellets for effective palliative care in rheumatoid arthritis

Author(s):  
Viral Shah ◽  
Garvit Hathi ◽  
Manju Misra ◽  
Manish Nivsarkar
Author(s):  
Eda Tonga ◽  
Esther Williamson ◽  
Cynthia Srikesavan ◽  
Tuğçe Özen ◽  
Fatih Sarıtaş ◽  
...  

2014 ◽  
Vol 32 (31_suppl) ◽  
pp. 36-36
Author(s):  
Lynne Slaughter Padgett ◽  
Mary Helen Davis ◽  
Colleen Tallen ◽  
Andrew Jdaydani ◽  
Angela Carrigan

36 Background: There is a paucity of research providing evaluation of implementation strategies contributing to provision of high quality early palliative care. Data from the NCI Community Cancer Centers Program (NCCCP) offers insight into ways in which patients, providers, and systems negotiate the provision of early palliative care in the community setting. The purpose of this project was to test the implementation of early palliative care programs for patients diagnosed with a high lethality cancer in participating NCCCP centers. Methods: Thirteen of 21 NCCCP sites elected to participate. Data on project activities and progress was gathered quarterly between July 2012 and June 2014. Qualitative data were evaluated using inductive and deductive methods and models of care, barriers and strategies were identified. Results: Models of care described included group education visits for patients and caregivers, outpatient clinics, and electronic consultation referral triggers. Irrespective of the model of care, sites reported barriers at the patient, provider and system levels. Barriers included reluctance by both patients and providers to consider palliative care services due to the perception of "giving up," and inadequate staffing and clinic space were also cited as systemic barriers. Strategies for facilitating implementation included integrating palliative care staff into existing cancer center programs (e.g., multi-disciplinary clinics), electronic referrals, and utilizing navigation services, as well as a variety of programs targeted to increase oncologist "buy-in." Conclusions: These results provide guidance for both researchers and clinicians in designing future multi-level interventions to facilitate the delivery of early palliative care, and the importance of identifying and utilizing provider and system resources in program design, development and promotion. Provider buy-in is an essential factor, but patient and system resources are equally important components of a successful implementation strategy.


2018 ◽  
Author(s):  
Cynthia Srikesavan ◽  
Esther Williamson ◽  
Tim Cranston ◽  
John Hunter ◽  
Jo Adams ◽  
...  

2021 ◽  
Vol 27 ◽  
pp. 275-280
Author(s):  
Kiran Mahendru ◽  
Nishkarsh Gupta ◽  
Manish Soneja ◽  
Rajeev Kumar Malhotra ◽  
Vinod Kumar ◽  
...  

Objectives: Rheumatoid arthritis (RA) is a chronic disorder causing inflammation in the joints and achieving remission is often the primary goal of physicians. We evaluated the suffering from RA and assessed the need for palliative care services in these patients. Materials and Methods: This cross-sectional observational study was done in 100 adult RA cases who attended the outpatient department. The Disease Activity Score 28 (DAS28), Health Assessment Questionnaire Disability Index, depression, anxiety and stress score, Short Form 36 Health Survey and numeric rating scale were assessed. The relationship between DAS28 with the other parameters and scores was assessed using Spearman’s rho correlation coefficient. Results: About 90% of patients in our study were female and majority (50%) had a moderate disease activity. The DAS28 showed a positive correlation with the degree of depression (r = 0.671, P = 0.000), anxiety (r = 0.609, P = 0.000) and stress levels (r = 0.474, P = 0.000). The patients with severe disease had a poor quality of life (QoL) [physical functioning (r = –0.737, P = 0.000); role limitation (r = –0.662, P = 0.000); emotional problem (r = –0.676, P = 0.000); energy/fatigue (r = –0.638, P = 0.000); social functioning (r = –0.658, P = 0.000); emotional well-being (r = –0.605, P = 0.000); general health (r = –0.643, P = 0.000); health change (r = –0.376, P = 0.000) and numerical rating scale score for pain (r = 0.656, P = 0.000)]. Conclusion: RA patients with high disease activity suffer from depression, anxiety, stress and poor QoL. Palliative care physicians and rheumatologists must be vested with the power to provide comprehensive care to these patients.


2017 ◽  
Vol 19 (12) ◽  
pp. e411 ◽  
Author(s):  
Cynthia Swarnalatha Srikesavan ◽  
Esther Williamson ◽  
Lucy Eldridge ◽  
Peter Heine ◽  
Jo Adams ◽  
...  

10.2196/10457 ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. e10457 ◽  
Author(s):  
Cynthia Srikesavan ◽  
Esther Williamson ◽  
Tim Cranston ◽  
John Hunter ◽  
Jo Adams ◽  
...  

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