Gene expression in canine atopic dermatitis and correlation with clinical severity scores

2009 ◽  
Vol 55 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Shona H. Wood ◽  
Dylan N. Clements ◽  
William E. Ollier ◽  
Tim Nuttall ◽  
Neil A. McEwan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atopic Dermatitis ◽  
Clinical Severity ◽  
Canine Atopic Dermatitis ◽  
Severity Scores

scholarly journals HPV Strain Predicts Severity of Juvenile-Onset Recurrent Respiratory Papillomatosis with Implications for Disease Screening

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2556
Author(s):  
Mary C. Bedard ◽  
Alessandro de Alarcon ◽  
Yann-Fuu Kou ◽  
David Lee ◽  
Alexandra Sestito ◽  
...  
Keyword(s):  
Gene Expression ◽  
Disease Severity ◽  
Disease Onset ◽  
Tissue Bank ◽  
Benign Neoplasm ◽  
Recurrent Respiratory Papillomatosis ◽  
Clinical Severity ◽  
Viral Gene ◽  
Juvenile Onset ◽  
Severity Scores

Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is the most common benign neoplasm of the larynx in children, presenting with significant variation in clinical course and potential for progression to malignancy. Since JoRRP is driven by human papillomavirus (HPV), we evaluated viral factors in a prospective cohort to identify predictive factors of disease severity. Twenty children with JoRRP undergoing routine debridement of papillomas were recruited and followed for ≥1 year. Demographical features, clinical severity scores, and surgeries over time were tabulated. Biopsies were used to establish a tissue bank and primary cell cultures for HPV6 vs. HPV11 genotyping and evaluation of viral gene expression. We found that patients with HPV11+ disease had an earlier age at disease onset, higher frequency of surgeries, increased number of lifetime surgeries, and were more likely to progress to malignancy. However, the amplitude of viral E6/E7 gene expression did not account for increased disease severity in HPV11+ patients. Determination of HPV strain is not routinely performed in the standard of care for JoRRP patients; we demonstrate the utility and feasibility of HPV genotyping using RNA-ISH for screening of HPV11+ disease as a biomarker for disease severity and progression in JoRRP patients.

Alterations of keratins, involucrin and filaggrin gene expression in canine atopic dermatitis

2012 ◽  
Vol 93 (3) ◽  
pp. 1287-1292 ◽  
Author(s):  
Sirin Theerawatanasirikul ◽  
Achariya Sailasuta ◽  
Roongroje Thanawongnuwech ◽  
Gunnaporn Suriyaphol
Keyword(s):  
Gene Expression ◽  
Atopic Dermatitis ◽  
Canine Atopic Dermatitis

scholarly journals Expression of Th1 cytokine mRNA in canine atopic dermatitis correlates with clinical severity

2004 ◽  
Vol 15 (s1) ◽  
pp. 2-2
Author(s):  
T. J. Nuttall ◽  
P. A. Knight ◽  
S. M. McAleese ◽  
J. Brown ◽  
J. R. Lamb ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Severity ◽  
Cytokine Mrna ◽  
Canine Atopic Dermatitis ◽  
Th1 Cytokine

scholarly journals Complementary and Integrative Therapies for Childhood Atopic Dermatitis

Children ◽  
2019 ◽  
Vol 6 (11) ◽  
pp. 121 ◽  
Author(s):  
Adrienne L. Adler-Neal ◽  
Abigail Cline ◽  
Travis Frantz ◽  
Lindsay Strowd ◽  
Steven R. Feldman ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Condition ◽  
Clinical Severity ◽  
Randomized Controlled Clinical Trials ◽  
Treatment Regimens ◽  
Length Of Treatment ◽  
Severity Scores ◽  
Complementary And Integrative Medicine ◽  
The Individual ◽  
Integrative Therapies

Background: Childhood atopic dermatitis is a chronic inflammatory skin condition that causes significant psychological and financial costs to the individual and society. Treatment regimens may require long-term medication adherence and can be associated with poor patient satisfaction. There is considerable interest in complementary and integrative medicine (CIM) approaches for childhood atopic dermatitis. Objective: To assess the effects of CIM approaches on childhood atopic dermatitis outcomes as defined by randomized, controlled clinical trials. Methods: A PubMed review of CIM-related treatments for pediatric atopic dermatitis was performed, and data related to age, study population, efficacy, treatment regimen, length of treatment, and sample size were included. Results: The search yielded 20 trials related to probiotic/prebiotic treatments for atopic dermatitis, three on the effects of vitamins on children with atopic dermatitis, and two on the effects of Chinese herbal treatments for atopic dermatitis in children and adolescents. The strongest evidence was for supplementation with the probiotics L. fermentum and L. plantarum. Conclusions: Certain strains of probiotics, specifically L. plantarum and L. fermentum, may improve clinical severity scores in children with atopic dermatitis. However, additional trials are needed to more thoroughly delineate the effects of additional integrative therapies on childhood atopic dermatitis.

scholarly journals Mortality prediction in sepsis via gene expression analysis: a community approach

2016 ◽  
Author(s):  
Timothy E Sweeney ◽  
Thanneer M Perumal ◽  
Ricardo Henao ◽  
Marshall Nichols ◽  
Judith A Howrylak ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Stratification ◽  
Unmet Need ◽  
Predictive Performance ◽  
Mortality Prediction ◽  
Clinical Severity ◽  
Prognostic Models ◽  
Improve Risk Stratification ◽  
Severity Scores ◽  
Community Onset

AbstractImproved risk stratification and prognosis in sepsis is a critical unmet need. Clinical severity scores and available assays such as blood lactate reflect global illness severity with suboptimal performance, and do not specifically reveal the underlying dysregulation of sepsis. Here three scientific groups were invited to independently generate prognostic models for 30-day mortality using 12 discovery cohorts (N=650) containing transcriptomic data collected from primarily community-onset sepsis patients. Predictive performance was validated in 5 cohorts of community-onset sepsis patients (N=189) in which the models showed summary AUROCs ranging from 0.765-0.89. Similar performance was observed in 4 cohorts of hospital-acquired sepsis (N=282). Combining the new gene-expression-based prognostic models with prior clinical severity scores led to significant improvement in prediction of 30-day mortality (p<0.01). These models provide an opportunity to develop molecular bedside tests that may improve risk stratification and mortality prediction in patients with sepsis, improving both resource allocation and prognostic enrichment in clinical trials.

scholarly journals IgE reactivity to Pacific cod (Gadus macrocephalus) fish allergens in dogs with canine atopic dermatitis

2019 ◽  
Vol 143 (2) ◽  
pp. AB67
Author(s):  
Ichiro Imanishi ◽  
Jumpei Uchiyama ◽  
Takako Matsuda ◽  
Keijiro Mizukami ◽  
Hidekatsu Shimakura ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pacific Cod ◽  
Canine Atopic Dermatitis ◽  
Ige Reactivity ◽  
Pacific Cod Gadus Macrocephalus ◽  
Gadus Macrocephalus

scholarly journals Ethnicity-based bias in clinical severity scores

2021 ◽  
Vol 3 (4) ◽  
pp. e209-e210
Author(s):  
Thomas Gumbsch ◽  
Karsten Borgwardt
Keyword(s):  
Clinical Severity ◽  
Severity Scores

scholarly journals Variable immunodeficiency score upfront analytical link (VISUAL), a proposal for combined prognostic score at diagnosis of common variable immunodeficiency

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kissy Guevara-Hoyer ◽  
Adolfo Jiménez-Huete ◽  
Julia Vasconcelos ◽  
Esmeralda Neves ◽  
Silvia Sánchez-Ramón
Keyword(s):  
Common Variable Immunodeficiency ◽  
Severity Score ◽  
Prognostic Score ◽  
Clinical Severity ◽  
Risk Category ◽  
Close Monitoring ◽  
Accurate Identification ◽  
Visual Score ◽  
Severity Scores ◽  
Common Variable

AbstractThe broad and heterogeneous clinical spectrum that characterizes common variable immunodeficiency (CVID) is associated with quite different disease course and prognosis, highlighting the need to develop tools that predict complications. We developed a multianalyte VISUAL score (variable immunodeficiency score upfront analytical link) aimed to predict severity using individual CVID patient data at baseline of a cohort of 50 CVID patients from two different centers in Portugal and Spain. We retrospectively applied VISUAL to the CVID clinical severity scores proposed by Ameratunga and Grimbacher after 15 years follow-up of our cohort. VISUAL score at CVID diagnosis showed adequate performance for predicting infectious and non-infectious severe complications (Cluster B). Compared to switched memory B lymphocyte phenotype alone, VISUAL provided a more accurate identification of clinically meaningful outcome, with significantly higher sensitivity (85% vs 55%, p = 0.01), and negative predictive value (77% vs 58%) and AUC of the ROC curves (0.72 vs 0.64), with optimal cut-off level of 10. For every increase of 1 point in the VISUAL scale, the odds of being in the higher risk category (Cluster B) increased in 1.3 (p = 0.005) for Ameratunga’s severity score and 1.26 (p = 0.004) for Grimbacher’s severity score. At diagnosis of CVID, VISUAL score ≥ 10 showed 8.94-fold higher odds of severe prognosis than below this threshold. Kaplan–Meier estimates for the VISUAL ≥ 10 points showed significantly earlier progression to Cluster B than those with VISUAL < 10 (p = 0.0002). This prognostic laboratory score might allow close monitoring and more aggressive treatment in patients with scores ≥ 10 on a personalized basis approach. Further studies are needed to prospectively validate VISUAL score.

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