Epithelial to mesenchymal transition markers are associated with an increased metastatic risk in primary cutaneous squamous cell carcinomas but are attenuated in lymph node metastases

2013 ◽  
Vol 72 (2) ◽  
pp. 93-102 ◽  
Author(s):  
Agustí Toll ◽  
Emili Masferrer ◽  
M.E. Hernández-Ruiz ◽  
Carla Ferrandiz-Pulido ◽  
Mireia Yébenes ◽  
...  
Keyword(s):  
Lymph Node ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Epithelial To Mesenchymal Transition ◽  
Squamous Cell Carcinomas ◽  
Mesenchymal Transition ◽  
Node Metastases ◽  
Metastatic Risk

scholarly journals Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases

2021 ◽  
Vol 28 (3) ◽  
pp. 1886-1898
Author(s):  
Christian Flörke ◽  
Aydin Gülses ◽  
Christina-Randi Altmann ◽  
Jörg Wiltfang ◽  
Henning Wieker ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Patient Specific ◽  
Infiltration Depth ◽  
Tumor Grading ◽  
Node Metastases

The current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis was evaluated. Additionally, the effect of contralateral metastases on the prognosis was examined. Metastases of the contralateral side occurred most frequently in squamous cell carcinomas of the palate and floor of the mouth. Furthermore, tumors with a high T status resulted in significantly higher rates of contralateral metastases. Similarly, the midline involvement, tumor grading, existing ipsilateral metastases, and the infiltration depth of the tumor had a highly significant influence on the development of lymph node metastases on the opposite side. Oral squamous cell carcinomas require a patient-specific decision. There is an ongoing need for further prospective studies to confirm the validity of the prognostic factors described herein.

An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

2005 ◽  
Vol 37 (2) ◽  
pp. 182-186 ◽  
Author(s):  
Paul Roepman ◽  
Lodewyk F A Wessels ◽  
Nienke Kettelarij ◽  
Patrick Kemmeren ◽  
Antony J Miles ◽  
...  
Keyword(s):  
Lymph Node ◽  
Head And Neck ◽  
Expression Profile ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Node Metastases

Molecular prediction of lymph node metastases using immunohistochemical analysis of primary oral tongue squamous cell carcinomas.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 6054-6054
Author(s):  
Furrat Amen ◽  
Michael Eden ◽  
Alison Marker ◽  
Bill Barrett ◽  
Philip Wilson ◽  
...  
Keyword(s):  
Lymph Node ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Immunohistochemical Analysis ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue ◽  
Node Metastases

Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases

2002 ◽  
Vol 197 (1) ◽  
pp. 60-71 ◽  
Author(s):  
Angela Hague ◽  
Graham Packham ◽  
Suzanne Huntley ◽  
Kathryn Shefford ◽  
John W. Eveson
Keyword(s):  
Lymph Node ◽  
Protein Expression ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Node Metastases

Comparison of Quantitative DNA Measurements and Cytomorphology in Squamous Cell Carcinomas of the Upper Aerodigestive Tract with and without Lymph Node Metastases

1993 ◽  
Vol 102 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Hans-Juergen Welkoborsky ◽  
Jack L. Gluckman ◽  
Wolf J. Mann ◽  
James E. Freije
Keyword(s):  
Lymph Node ◽  
Squamous Cell ◽  
Dna Content ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Malignancy Grade ◽  
Node Metastases ◽  
Dna Measurements

Cytologic smears of squamous cell carcinomas (UICC T2 through T4) from the mucosa of the upper aerodigestive tract without cervical lymph node metastases (n = 10) and with metastases (n = 20) were examined. Subsequently, the cytologic smears of the metastases (n = 20) obtained by fine-needle aspiration or following neck dissection were evaluated morphologically. Each specimen was then stained with Papanicolaou and Feulgen techniques, and quantitative DNA measurements were performed with an image analysis system. Morphologically, the primary tumors with metastases revealed an increased mean nuclear perimeter and mean nuclear area compared with tumors unassociated with metastases. On quantitative DNA measurements, the tumors with metastases had an increased DNA content, a higher 2c deviation index, and a higher DNA malignancy grade and increased number of aneuploid cells. The specimens obtained from the metastatic nodes yielded the highest values for mean DNA content, 2c deviation index, aneuploidy, and malignancy grade. The stem lines of metastasis were always nondiploid. These data indicate a positive correlation between aneuploid tumor cell clones in primary cancer and the manifestation of lymph node metastases.

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