Characterization of simple intercellular lipid model of atopic dermatitis stratum corneum containing sphingosine and sphinganine

2017 ◽  
Vol 86 (2) ◽  
pp. e43-e44 ◽  
Author(s):  
Yasuko Obata ◽  
Hiromu Sano ◽  
Noboru Ohta ◽  
Taro Moriwaki ◽  
Kenya Ishida ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Intercellular Lipid

scholarly journals Characterization of silver particles in the stratum corneum of healthy subjects and atopic dermatitis patients dermally exposed to a silver-containing garment

2016 ◽  
Vol 10 (10) ◽  
pp. 1480-1491 ◽  
Author(s):  
Carlotta Bianco ◽  
Maaike J. Visser ◽  
Olivier A. Pluut ◽  
Vesna Svetličić ◽  
Galja Pletikapić ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Healthy Subjects ◽  
Silver Particles

scholarly journals Characterization of Classical Flexural and Nummular Forms of Atopic Dermatitis in Childhood with Regard to Anamnestic, Clinical and Epidermal Barrier Aspects

2021 ◽  
Author(s):  
Folke Hüppop ◽  
Stephan Dähnhardt-Pfeiffer ◽  
Regina Fölster-Holst
Keyword(s):  
Atopic Dermatitis ◽  
Transepidermal Water Loss ◽  
First Year ◽  
Therapeutic Approaches ◽  
Electron Microscopic ◽  
First Year Of Life ◽  
Distinguishing Features ◽  
Intercellular Lipid

Nummular (coin-shaped) and classical (flexural) atopic dermatitis differ morphologically, but no other distinguishing features are known. The aim of this study was to determine differences and similarities of both variants in children. Detailed interviews, clinical examinations, biophysical measurements and electron microscopic analyses were performed on 10 children with nummular atopic dermatitis, 14 with classical atopic dermatitis and 10 healthy controls. Nummular atopic dermatitis affected more boys than girls and manifested less frequently within the first year of life than classical atopic dermatitis. Localization, distribution and morphology of the eczema varied more over time, and expression of keratosis pilaris was more severe in children with nummular atopic dermatitis. Both disease groups showed reduced hydration, increased transepidermal water loss and reduced intercellular lipid lamellae in lesional skin areas compared with non-lesional areas. These findings underline the separate classification of both variants. Further research is necessary to investigate the potential of diverging therapeutic approaches.

Changes in corneocyte element concentrations occur in skin inner stratum corneum

1990 ◽  
Vol 48 (2) ◽  
pp. 146-147
Author(s):  
R. R. Warner
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Element Concentration ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Brick Wall ◽  
Inorganic Elements ◽  
Dry Skin ◽  
Skin Biopsies ◽  
Intercellular Lipid

Keratinocytes undergo maturation during their transit through the viable layers of skin, and then abruptly transform into flattened, anuclear corneocytes that constitute the cellular component of the skin barrier, the stratum corneum (SC). The SC is generally considered to be homogeneous in its structure and barrier properties, and is often shown schematically as a featureless brick wall, the “bricks” being the corneocytes, the “mortar” being intercellular lipid. Previously we showed the outer SC was not homogeneous in its composition, but contained steep gradients of the physiological inorganic elements Na, K and Cl, likely originating from sweat salts. Here we show the innermost corneocytes in human skin are also heterogeneous in composition, undergoing systematic changes in intracellular element concentration during transit into the interior of the SC.Human skin biopsies were taken from the lower leg of individuals with both “good” and “dry” skin and plunge-frozen in a stirred, cooled isopentane/propane mixture.

Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis

Allergy ◽  
2021 ◽  
Author(s):  
Arturo O. Rinaldi ◽  
Angelica Korsfeldt ◽  
Siobhan Ward ◽  
Daniel Burla ◽  
Anita Dreher ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Skin Barrier ◽  
Electrical Impedance Spectroscopy

Evaluation of intercellular lipid lamellae in the stratum corneum by polarized microscopy

2021 ◽  
Author(s):  
Naoki Asada ◽  
Ryo Morita ◽  
Rikae Kamiji ◽  
Mami Kuwajima ◽  
Masahiko Komorisono ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Polarized Microscopy ◽  
Intercellular Lipid
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