Characterization of Classical Flexural and Nummular Forms of Atopic Dermatitis in Childhood with Regard to Anamnestic, Clinical and Epidermal Barrier Aspects

Acta Dermato Venereologica ◽

10.2340/actadv.v101.979 ◽

2021 ◽

Author(s):

Folke Hüppop ◽

Stephan Dähnhardt-Pfeiffer ◽

Regina Fölster-Holst

Keyword(s):

Atopic Dermatitis ◽

Transepidermal Water Loss ◽

First Year ◽

Therapeutic Approaches ◽

Electron Microscopic ◽

First Year Of Life ◽

Distinguishing Features ◽

Intercellular Lipid

Nummular (coin-shaped) and classical (flexural) atopic dermatitis differ morphologically, but no other distinguishing features are known. The aim of this study was to determine differences and similarities of both variants in children. Detailed interviews, clinical examinations, biophysical measurements and electron microscopic analyses were performed on 10 children with nummular atopic dermatitis, 14 with classical atopic dermatitis and 10 healthy controls. Nummular atopic dermatitis affected more boys than girls and manifested less frequently within the first year of life than classical atopic dermatitis. Localization, distribution and morphology of the eczema varied more over time, and expression of keratosis pilaris was more severe in children with nummular atopic dermatitis. Both disease groups showed reduced hydration, increased transepidermal water loss and reduced intercellular lipid lamellae in lesional skin areas compared with non-lesional areas. These findings underline the separate classification of both variants. Further research is necessary to investigate the potential of diverging therapeutic approaches.

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Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

npj Breast Cancer ◽

10.1038/s41523-020-00197-2 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Antonio Marra ◽

Dario Trapani ◽

Giulia Viale ◽

Carmen Criscitiello ◽

Giuseppe Curigliano

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Residual Disease ◽

Therapeutic Approaches ◽

Minimal Residual Disease Monitoring ◽

Anticancer Treatment ◽

Immune Contexture

Abstract Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple entities with marked histopathological, transcriptomic and genomic heterogeneity. Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across TNBC subtypes, prompting the implementation of biomarker-driven therapeutic approaches. However, biomarker-based treatments as well as immune checkpoint inhibitor-based immunotherapy have provided contrasting and limited results so far. Accordingly, a better characterization of the genomic and immune contexture underpinning TNBC, as well as the translation of the lessons learnt in the metastatic disease to the early setting would improve patients’ outcomes. The application of multi-omics technologies, biocomputational algorithms, assays for minimal residual disease monitoring and novel clinical trial designs are strongly warranted to pave the way toward personalized anticancer treatment for patients with TNBC.

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A multinational study to compare prevalence of atopic dermatitis in the first year of life

Pediatric Allergy and Immunology ◽

10.1111/pai.12388 ◽

2015 ◽

Vol 26 (4) ◽

pp. 359-366 ◽

Cited By ~ 17

Author(s):

Eelco Draaisma ◽

Luis Garcia-Marcos ◽

Javier Mallol ◽

Dirceu Solé ◽

Virginia Pérez-Fernández ◽

...

Keyword(s):

Atopic Dermatitis ◽

First Year ◽

Multinational Study ◽

First Year Of Life

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A Neonate with Down’s Syndrome and Transient Abnormal Myelopoiesis: Serial Blood and Bone Marrow Studies

Blood ◽

10.1182/blood.v36.4.443.443 ◽

1970 ◽

Vol 36 (4) ◽

pp. 443-447 ◽

Cited By ~ 36

Author(s):

TAKESHI NAGAO ◽

BEATRICE C. LAMPKIN ◽

GEORGE HUG

Keyword(s):

Bone Marrow ◽

Marrow Cell ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Male Infant ◽

First Year ◽

Electron Microscopic ◽

Transient Abnormal Myelopoiesis ◽

Microscopic Studies ◽

First Year Of Life

Abstract Observations were made of the blood and bone marrow of a male infant with Down’s syndrome during the first year of life. At 4 days of age there were 36,500 myeloblasts/cu.mm. in the blood and 10.8 per cent myeloblasts in the marrow. Initially it appeared the patient had acute myeloblastic leukemia. However, the clinical course and kinetic and electron microscopic studies of his bone marrow cell population indicate he did not have acute leukemia.

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Characterization of Electrophoretic Lipoprotein Fractions: Immunochemical and Electron Microscopic Studies

Clinical Chemistry ◽

10.1093/clinchem/18.6.534 ◽

1972 ◽

Vol 18 (6) ◽

pp. 534-538

Author(s):

Mario Werner ◽

Albert L Jones

Keyword(s):

Electron Microscopy ◽

Particle Size ◽

Electrophoretic Pattern ◽

Electron Microscopic ◽

Lipoprotein Subfractions ◽

New Techniques ◽

Microscopic Studies ◽

Insight Into

Abstract To improve the characterization of electrophoretic lipoprotein subfractions, we developed two new techniques for analyzing lipoproteins after electrophoresis on thin agarose layers. Overlay with antisera exactly localizes specific apoproteins without any distortion caused by antigen diffusion; electron microscopy of eluted fractions determines the varying particle-size distribution. Applied together, these methods can detect individual differences between hyperlipemic samples that are not immediately apparent in the electrophoretic pattern, and should provide valuable new insight into the classification of hyperlipoproteinemias.

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Development of penis and sheath in young dairy bulls, and its relationship to age and body weight

The Journal of Agricultural Science ◽

10.1017/s0021859600008807 ◽

1962 ◽

Vol 58 (1) ◽

pp. 65-69 ◽

Cited By ~ 5

Author(s):

B. R. Ashdown

Keyword(s):

Body Weight ◽

Linear Regression ◽

Sexual Development ◽

First Year ◽

Bull Calves ◽

Breed Differences ◽

Dairy Bulls ◽

First Year Of Life ◽

Development Proceeds

1. Eighty-six bull calves (fifty-two Friesian, twenty-two Ayrshire, twelve Shorthorn) were examined at intervals, during the first year of life, by a method which allowed classification of the degree of adherence between penis and sheath into five classes.2. Mean age and weight at which separation between penis and sheath commenced and was completed are recorded for each breed. Significant breed differences were found.3. The rate of separation accelerates as development proceeds.4. The relationships between age, body weight, and commencement and completion of separation in the Friesian bulls are analysed by correlation methods. These analyses suggest that both age and body weight are important in sexual development.5. An equation is given for the linear regression of age at completion of separation on age and weight at commencement of separation and weight at 10 weeks for the Friesian bulls.

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Perinatal risk factors for sensitization, atopic dermatitis and wheezing during the first year of life (PIPO study)

Clinical & Experimental Allergy ◽

10.1111/j.1365-2222.2005.02254.x ◽

2005 ◽

Vol 35 (6) ◽

pp. 733-740 ◽

Cited By ~ 38

Author(s):

M. M. Hagendorens ◽

C. H. Bridts ◽

K. Lauwers ◽

S. van Nuijs ◽

D. G. Ebo ◽

...

Keyword(s):

Risk Factors ◽

Atopic Dermatitis ◽

First Year ◽

Perinatal Risk Factors ◽

Perinatal Risk ◽

First Year Of Life

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Lingual means of the denotation in the Ukrainian language for age development periods of a child in the first year of the life

Philological Review ◽

10.31499/2415-8828.2.2021.246073 ◽

2021 ◽

pp. 30-36

Author(s):

Oksana Zelinska ◽

Maryna Holoborodko

Keyword(s):

Perinatal Period ◽

Prenatal Development ◽

First Year ◽

Physiological Changes ◽

Conversational Speech ◽

Pedagogical Discourse ◽

One Year ◽

First Year Of Life ◽

Early Late

The names of age periods of the first year of a child’s life were considered in the paper. Traditionally the first year of a child’s life was not clearly divided into shorter stages, and in turn, there were no established names which would correlate with these age periods. In every-day life defining features for a child of the first year of life is the fact of birth itself, which fixes a noun-composite a newly-born, as well as expressive signs associated with feeding a baby and its (his/her) inability to speak, namely, such nouns as a nursling and a baby. A clearly differentiated division of a child’s age period, before reaching the age of one year, is recorded in medicine. Scientific observations of the physiological changes in the development of a child, depending on a lived calendar period, determined the classification of the life into certain stages beginning from the prenatal development; it was expressed in a special terminology, for example, a perinatal period, a zero day. In a medical sphere the division units of a life period before the age of one year are hours, days, months; thus, this temporal vocabulary belongs to the structure of terminological phrases used to denote a certain age stage, the gradation of periods can be done with help of adjectives-qualifiers early, late. In a pedagogical discourse, contrary to a medical sphere, the names of the age periods in a child’s life do not clearly correlate with physiological changes and a calendar duration, and in an every-day life discourse the correlation is seen the least. However a conversational speech is characterized with a larger number of the patterns which form the names of age periods, descriptive nominations, due to a child’s socialization. Thus, a set of nominative units is different for each discourse, but we can come across some scientific terms in mass media, and from there they can be found in a conversational speech. In a pedagogical, medical, every-day life discourse we have the cases when the same nouns are used, for instance, a newly-born, however they differ semantically.

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Atopic Dermatitis

Pediatrics in Review ◽

10.1542/pir.15.8.327 ◽

1994 ◽

Vol 15 (8) ◽

pp. 327-332

Author(s):

Candace S. Lapidus ◽

Paul J. Honig

Keyword(s):

Atopic Dermatitis ◽

Los Angeles ◽

Urban Areas ◽

Pediatric Population ◽

Pediatric Emergency ◽

First Year ◽

Pediatric Dermatology ◽

Low Humidity ◽

First Year Of Life ◽

Do So

Introduction Atopic dermatitis, also referred to as atopic eczema, infantile eczema, allergic eczema, disseminated neurodermatitis, and prurigo Besnier, is a common and important cause of morbidity in children of all ages. A total of 22% of patients seen in pediatric dermatology clinics have atopic dermatitis. In 1969, Wingert et al reported that 4% of pediatric emergency room visits at the Los Angeles County General Hospital were due to atopic dermatitis, and this did not include patients seen for impetigo, a common complication of atopic dermatitis. The prevalence of atopic dermatitis in the pediatric population has increased over the past 3 decades from 3% to 10%, and it appears to be even higher in heavily populated urban areas. Pediatricians, therefore, must understand its pathogenesis and management. Epidemiology Sixty percent of children who have atopic dermatitis manifest their disease in the first year of life; 90% do so by age 5 years. A genetically prone individual may not manifest the disease until exposed to a particular environmental situation. Onset has been associated with relocation from a rural to an urban location or from a region of high to low humidity. The course of adopic dermatitis is difficult to predict, although one 15-year longitudinal study revealed that the disease persisted in 60% of cases.

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