Acute Kidney Injury in the Critically Ill: Is Iodinated Contrast Medium Really Harmful?

2013 ◽  
Vol 45 (2) ◽  
pp. 313
Author(s):  
David Bosch
Keyword(s):  
Acute Kidney Injury ◽  
Contrast Medium ◽  
Critically Ill ◽  
Kidney Injury ◽  
Iodinated Contrast Medium ◽  
Iodinated Contrast

scholarly journals Risk of developing acute kidney injury (AKI) following the administration of iodinated contrast medium

2012 ◽  
Vol 12 (6) ◽  
pp. 607.2-608
Author(s):  
Derrick Martin ◽  
Alison Bradley
Keyword(s):  
Acute Kidney Injury ◽  
Contrast Medium ◽  
Kidney Injury ◽  
Iodinated Contrast Medium ◽  
Iodinated Contrast

Risk of acute kidney injury in cancer patients after iodinated contrast medium administration and prophylactic strategies: Summary from the most recent guidelines

2021 ◽  
pp. 239936932110285
Author(s):  
Pirovano Marta ◽  
Minei Silvia ◽  
Re Sartò Giulia Vanessa ◽  
Cosmai Laura
Keyword(s):  
Acute Kidney Injury ◽  
Contrast Medium ◽  
Cancer Patients ◽  
Kidney Injury ◽  
Post Contrast ◽  
Iodinated Contrast Medium ◽  
Iodinated Contrast ◽  
Contrast Enhanced ◽  
Nephrotoxic Drugs ◽  
Enhanced Computed Tomography

Post-contrast acute kidney injury (PC-AKI) is a serious complication that primarily affects people with multiple comorbidities who undergo imaging examination with iodinated contrast medium (CM), worsening their outcome and prognosis. This is particularly true for cancer patients, for whom contrast enhanced computed tomography (CECT) is of considerable value in diagnosis and management of the tumor and who are frequently subjected to dehydration and administration of nephrotoxic drugs. The debate on the real prevalence and severity of acute kidney injury (AKI) due to CM administration is still ongoing and the lack of controlled studies and reliable evidence has generated wide heterogeneity in patient management and prophylaxis. The whole idea of this protocol is to analyze most up-to-date guidelines on preventing AKI due to CM administration trying to provide a practical guide.

scholarly journals Iodinated contrast medium: Is there a re(n)al problem? A clinical vignette-based review

Critical Care ◽  
2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Karim Lakhal ◽  
Stephan Ehrmann ◽  
Vincent Robert-Edan
Keyword(s):  
Acute Kidney Injury ◽  
Contrast Media ◽  
Kidney Injury ◽  
Case Vignette ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast Medium ◽  
Iodinated Contrast ◽  
Prophylactic Measures ◽  
Indirect Consequence ◽  
Toxic Potential

Abstract As we were taught, for decades, that iodinated contrast-induced acute kidney injury should be dreaded, considerable efforts were made to find out effective measures in mitigating the renal risk of iodinated contrast media. Imaging procedures were frequently either downgraded (unenhanced imaging) or deferred as clinicians felt that the renal risk pertaining to contrast administration outweighed the benefits of an enhanced imaging. However, could we have missed the point? Among the abundant literature about iodinated contrast-associated acute kidney injury, recent meaningful advances may help sort out facts from false beliefs. Hence, there is increasing evidence that the nephrotoxicity directly attributable to modern iodinated CM has been exaggerated. Failure to demonstrate a clear benefit from most of the tested prophylactic measures might be an indirect consequence. However, the toxic potential of iodinated contrast media is well established experimentally and should not be overlooked completely when making clinical decisions. We herein review these advances in disease and pathophysiologic understanding and the associated clinical crossroads through a typical case vignette in the critical care setting.

scholarly journals Prevention of contrast-associated acute kidney injury in cancer patients undergoing radiologic investigation using contrast media; a short-review to current knowledge

2019 ◽  
Vol 8 (4) ◽  
pp. 43-43 ◽  
Author(s):  
Mohamad Ali Dayani ◽  
Azin Mirzazadeh
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Contrast Medium ◽  
Current Knowledge ◽  
Kidney Injury ◽  
Short Review ◽  
Biologically Active ◽  
Iodinated Contrast

Contrast agents are non-biologically active substances required for various diagnostic imaging procedures. Exposure to contrast materials, predispose some patients to renal disturbances entitled as contrast-associated acute kidney injury. Nephropathy of contrast medium is a deterioration of renal function which happens within 24 to 72 hours after iodinated contrast medium injection. Cancer individuals have several risk factors for contrast-associated acute renal failure, consisting of administration of chemotherapy regimen, which are mainly nephrotoxic, presence of diabetes or chronic renal failure, hypertension, taking of non-steroidal anti-inflammatory drugs, simultaneous use of nephrotoxic drugs, aminoglycosides, cisplatin, cyclosporine A or amphotericin B, increases the risk of contrast-associated acute renal failure. Similarly, age more than65 years old and anemia is an independent risk factor for contrast-associated acute kidney injury and also timing of CT within 45 days after last chemotherapy and low fluid intake, as the common risk factors in cancer individuals.

Safety of Argatroban in critically ill patients with acute kidney injury and renal replacement therapy after cardiac surgery

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
M Klingele ◽  
A Lerner-Gräber ◽  
D Fliser ◽  
HJ Schäfers ◽  
H Groesdonk
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Kidney Injury
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