Natural History and Clinical Implications of Nondepressed Skull Fracture in Young Children

This study explores the lived experiences of members of lesbian-parented families incorporating a systemic perspective to include both the voices of mothers and their young children. Eight whole-family interviews were conducted with lesbian couples with at least one child in elementary school (aged 5–11). Six themes emerged from the study: intentionality in finding places to live and travel, having children, and having discussions with their children; views of themselves as advocates and being “out” in their communities; noticing how times are changing; identifying assumptions as a two-way street; perceptions of gender surrounding parenting and the salience of various identities; and the dialectical tension between wanting to be perceived as normal and wanting to acknowledge their uniqueness. Clinical implications and suggestions for future research are discussed.

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The Natural History of Peanut Allergy in Young Children and Its Association with Serum Peanut-Specific IgE

PEDIATRICS ◽

10.1542/peds.110.s2.434b ◽

2002 ◽

Vol 110 (Supplement_2) ◽

pp. 434-434

Author(s):

John M. James

Keyword(s):

Natural History ◽

Young Children ◽

Peanut Allergy ◽

Specific Ige ◽

History Of

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Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2019 Update and Clinical Implications

Aorta ◽

10.1055/s-0039-3400233 ◽

2019 ◽

Vol 07 (04) ◽

pp. 099-107 ◽

Cited By ~ 11

Author(s):

Thais Faggion Vinholo ◽

Adam J. Brownstein ◽

Bulat A. Ziganshin ◽

Mohammad A. Zafar ◽

Helena Kuivaniemi ◽

...

Keyword(s):

Aortic Aneurysm ◽

Natural History ◽

Molecular Genetics ◽

Thoracic Aortic Aneurysm ◽

Surgical Intervention ◽

Pathogenic Mutation ◽

Clinical Implications ◽

Aortic Aneurysm And Dissection

AbstractThoracic aortic aneurysm is a typically silent disease characterized by a lethal natural history. Since the discovery of the familial nature of thoracic aortic aneurysm and dissection (TAAD) almost 2 decades ago, our understanding of the genetics of this disorder has undergone a transformative amplification. To date, at least 37 TAAD-causing genes have been identified and an estimated 30% of the patients with familial nonsyndromic TAAD harbor a pathogenic mutation in one of these genes. In this review, we present our yearly update summarizing the genes associated with TAAD and the ensuing clinical implications for surgical intervention. Molecular genetics will continue to bolster this burgeoning catalog of culprit genes, enabling the provision of personalized aortic care.

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P.256Steroid treatment may change natural history in young children with LMNA mutations and dropped head syndrome

Neuromuscular Disorders ◽

10.1016/j.nmd.2019.06.370 ◽

2019 ◽

Vol 29 ◽

pp. S141

Author(s):

M. Gomez Garcia de la Banda ◽

D. Natera-De Benito ◽

I. Dabaj ◽

R. Ben Yaou ◽

C. Ortez ◽

...

Keyword(s):

Natural History ◽

Young Children ◽

Dropped Head Syndrome

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Pediatric ITP: is it different from adult ITP?

Hematology ◽

10.1182/asheducation-2018.1.405 ◽

2018 ◽

Vol 2018 (1) ◽

pp. 405-411 ◽

Cited By ~ 7

Author(s):

Jenny M. Despotovic ◽

Amanda B. Grimes

Keyword(s):

Natural History ◽

Young Children ◽

Immune Thrombocytopenia ◽

Management Strategies ◽

The Elderly ◽

Future Research ◽

Older Children ◽

Younger Adults ◽

Management Guidelines ◽

Similarities And Differences

Abstract Immune thrombocytopenia (ITP) has historically been thought to occur in 2 distinct forms: childhood ITP and adult ITP. This division is based largely on the presumption that childhood ITP is often benign and self-limited, whereas ITP in adults tends to be more chronic and difficult to treat. Although data exist to justify a different approach to the diagnosis and treatment in young children and the elderly, ITP in older children, adolescents, and younger adults is likely to share more similar pathology. This article will highlight the most recent data describing the natural history, diagnostic approach, management strategies, and disease-related outcomes in children and adults with ITP. These data reveal many unexpected similarities between the 2 groups, while confirming some of the more well-described differences. Discussion of these findings aims to highlight similarities and differences between ITP in children and adults, which will underscore important areas of future research and/or changes in management guidelines.

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Head and neck tumour immunology: basic concepts and new clinical implications

The Journal of Laryngology & Otology ◽

10.1017/s0022215108003368 ◽

2008 ◽

Vol 123 (1) ◽

pp. 9-18 ◽

Cited By ~ 1

Author(s):

K P Topping ◽

L M Fletcher ◽

F O Agada ◽

O Alhamarneh ◽

N D Stafford ◽

...

Keyword(s):

Head And Neck Cancer ◽

Immune System ◽

Natural History ◽

Structure Function ◽

Head And Neck ◽

Neck Cancer ◽

Clinical Implications ◽

Tumour Immunology ◽

Neck Tumour ◽

Basic Concepts

AbstractAn understanding of the immune system and its modes of action is fundamental to understanding the causes, natural history, management and treatment of many diseases. As such, a grasp of the principles of immunology is essential for every physician.This paper represents a succinct overview of the immune system, discussing the major components in turn, in respect of structure, function and integrated organisation, in relation to head and neck cancer.

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