Head and neck tumour immunology: basic concepts and new clinical implications

AbstractAn understanding of the immune system and its modes of action is fundamental to understanding the causes, natural history, management and treatment of many diseases. As such, a grasp of the principles of immunology is essential for every physician.This paper represents a succinct overview of the immune system, discussing the major components in turn, in respect of structure, function and integrated organisation, in relation to head and neck cancer.

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General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis

International Journal of Clinical Oncology ◽

10.1007/s10147-020-01812-9 ◽

2021 ◽

Vol 26 (4) ◽

pp. 623-635

Author(s):

Yoshihide Ota ◽

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Tadahide Noguchi ◽

Eiichiro Ariji ◽

Chihiro Fushimi ◽

...

Keyword(s):

Head And Neck Cancer ◽

Oral Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Medical Information ◽

English Edition ◽

General Rules ◽

Treatment Research ◽

Basic Concepts ◽

8Th Edition

AbstractFor doctors and other medical staff treating oral cancer, it is necessary to standardize the basic concepts and rules for oral cancer to achieve progress in its treatment, research, and diagnosis. Oral cancer is an integral part of head and neck cancer and is treated in accordance with the general rules for head and neck cancer. However, detailed rules based on the specific characteristics of oral cancer are essential. The objective of this article was to contribute to the development of the diagnosis, treatment, and research of oral cancer, based on the correct and useful medical information of clinical, surgical, pathological, and imaging findings accumulated from individual patients at various institutions. Our general rules were revised as the UICC was revised for the 8th edition and were published as the Japanese second edition in 2019. In this paper, the English edition of the “Rules” section is primarily presented.

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Current clinical immunotherapeutic approaches for head and neck cancer

F1000Research ◽

10.12688/f1000research.7762.1 ◽

2016 ◽

Vol 5 ◽

pp. 803 ◽

Cited By ~ 2

Author(s):

Carolina Soto Chervin ◽

Bruce Brockstein

Keyword(s):

Head And Neck Cancer ◽

Immune System ◽

Head And Neck ◽

Neck Cancer ◽

Hematological Malignancies ◽

Therapeutic Option ◽

Specific Treatment ◽

Clinical Development ◽

The Us ◽

The Status

It was estimated that 59,340 new cases of head and neck cancer would be diagnosed in the US alone in 2015 and that 12,290 deaths would be attributed to the disease. Local and regional recurrences may be treated with chemotherapy and radiation; however, metastatic head and neck cancer is fatal and is treated with chemotherapy for palliation. Recent successful treatment of a variety of solid and hematological malignancies by immunotherapeutic approaches (i.e. harnessing the body’s own immune system to combat disease) has added a fourth therapeutic option for the treatment of cancer. This commentary will review the status of immunotherapies in clinical development for the specific treatment of head and neck cancer.

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