Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis

AbstractMotor impairments and cognitive dysfunction are common in multiple sclerosis (MS). We aimed to delineate the relationship between cognitive capacity and upper and lower motor function in 211 MS patients, and 120 healthy volunteers. Lower and upper motor function were assessed with the Timed 25 Foot Walk (T25FW) and the Nine Hole Peg Test (NHPT) as implemented in the Multiple Sclerosis Functional Composite (MSFC). Subjects also underwent neuropsychological evaluation. Hierarchical linear regression analysis was conducted separately for the MS and healthy groups with the T25FW and NHPT serving as the outcome measures. Cognitive performance indices served as predictors. As expected, healthy subjects performed better than the MS group on all measures. Processing speed and executive function tests were significant predictors of lower and upper motor function in both groups. Correlations were more robust in the MS group, where cognitive tests predicted variability in motor function after controlling for disease duration and physical disability. In conclusion, we find evidence of higher order cognitive control of motor function that appears to be particularly salient in this large and representative MS sample. The findings may have implications for risk assessment and treatment of mobility dysfunction in MS. (JINS, 2011, 17, 643–653)

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Sensory nerve stimulation causes an immediate improvement in motor function of persons with multiple sclerosis: A pilot study

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2019.101508 ◽

2020 ◽

Vol 38 ◽

pp. 101508 ◽

Cited By ~ 1

Author(s):

Awad M. Almuklass ◽

Robyn A. Capobianco ◽

Daniel F. Feeney ◽

Enrique Alvarez ◽

Roger M. Enoka

Keyword(s):

Multiple Sclerosis ◽

Pilot Study ◽

Motor Function ◽

Nerve Stimulation ◽

Sensory Nerve

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Dalfampridine benefits ambulation but not cognition in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458518815795 ◽

2018 ◽

Vol 26 (1) ◽

pp. 91-98 ◽

Cited By ~ 9

Author(s):

Nikhil Satchidanand ◽

Allison Drake ◽

A Smerbeck ◽

David Hojnacki ◽

Channa Kolb ◽

...

Keyword(s):

Multiple Sclerosis ◽

Motor Function ◽

Test Performance ◽

Primary Outcome ◽

End Point ◽

Saltatory Conduction ◽

Impaired Cognition ◽

Serial Addition ◽

Outcome Performance ◽

Minute Walk

Background: Impaired cognition and ambulation are common in multiple sclerosis (MS). Dalfampridine is the first Food and Drug Administration (FDA)–approved medication to treat impaired ambulation in MS. Dalfampridine may benefit patients with cognitive impairment, given its effects on saltatory conduction and the association between cognitive and motor function. Objective: To examine the effects of dalfampridine on cognition in MS. To determine if the anticipated improved cognition is grounded in dalfampridine’s effects on ambulation. Methods: Adults with MS were randomized to dalfampridine ( n = 45) or placebo ( n = 16) for 12 weeks. Cognition and motor function were assessed at baseline and end-point. Results: T25FW and 6-minute walk (6MW) performance improved at end-point in the treatment group but not in the placebo group ( p < 0.05). Our primary outcome, performance on the Symbol Digit Modalities Test, did not improve. About 30% ( n = 12) of the dalfampridine group demonstrated ⩾20% improved ambulation and were categorized “responders.” Among “responders”, Symbol Digit Modalities test performance did not improve. However, performance on the Paced Auditory Serial Addition Test improved among “responders” ( p < 0.05). Conclusion: Dalfampridine benefits timed ambulation but not cognition. Some improvement among ambulation “responders” is consistent with prior reports of cognition-motor coupling in MS ( ClinicalTrials.gov #: NCT02006160).

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Orem’s Self-Care Model with Multiple Sclerosis Patients’ Balance and Motor Function

Nursing Science Quarterly ◽

10.1177/0894318419881792 ◽

2019 ◽

Vol 33 (1) ◽

pp. 46-54

Author(s):

Ardashir Afrasiabifar ◽

Zahra Mehri ◽

Hamid Reza Ghaffarian Shirazi

Keyword(s):

Multiple Sclerosis ◽

Motor Function ◽

Intervention Group ◽

Self Care ◽

Nursing Intervention ◽

Control Group ◽

Care Model ◽

Significant Difference ◽

The Mean ◽

Multiple Sclerosis Patients

Orem’s self-care model has been introduced as a nursing model to empower participants with chronic diseases. This study aims to investigate the effectiveness of nursing interventions using Orem’s self-care model with multiple sclerosis participants’ balance and motor function. Sixty-three participants with multiple sclerosis were randomly assigned to intervention and control groups. The nursing intervention using Orem’s self-care model was performed for eight sessions of 45–60 minutes in the intervention group. In the intervention group, a significant increase (improvement) was observed in the mean scores of balance before (17.09 ± 1.97) and after the intervention (33.75 ± 6.01). A significant decrease (improvement) was observed in the mean of motor functions before (4.12 ± 0.34) and after the intervention (1.59 ± 0.71) ( p = 0.001). However, no significant difference existed in the mean scores of balance ( p = 0.10) and motor function in the control group ( p = 0.20). The nursing intervention using Orem’s self-care model improved balance and motor function of participants with multiple sclerosis.

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