Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation

2014 ◽  
Vol 154 (3) ◽  
pp. 728-734 ◽  
Author(s):  
Yuhua Li ◽  
Lei Fan ◽  
Yang Sun ◽  
Xia Miao ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
P Glycoprotein ◽  
Trillium Tschonoskii ◽  
Glycoprotein Inhibition ◽  
Mcf 7

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 ◽  
Vol 3 (6) ◽  
pp. 181-189 ◽  
Author(s):  
Gang Yu ◽  
Shakeel Ahmad ◽  
Angelo Aquino ◽  
Craig R. Fairchild ◽  
Jane B. Trepel ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Protein Kinase ◽  
P Glycoprotein ◽  
Protein Kinase Cα ◽  
Mcf 7

scholarly journals The Effect of Survivin on Multidrug Resistance Mediated by P-Glycoprotein in MCF-7 and Its Adriamycin Resistant Cells

2007 ◽  
Vol 30 (12) ◽  
pp. 2279-2283 ◽  
Author(s):  
Feng Liu ◽  
Zhen-Hua Xie ◽  
Guo-Ping Cai ◽  
Yu-Yang Jiang
Keyword(s):  
Multidrug Resistance ◽  
P Glycoprotein ◽  
Mcf 7 ◽  
Resistant Cells

scholarly journals Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells

2016 ◽  
Vol 13 (6) ◽  
pp. 4745-4750 ◽  
Author(s):  
JINGRU JIANG ◽  
XIAOHONG WANG ◽  
KAI CHENG ◽  
WANZHONG ZHAO ◽  
YITONG HUA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Human Breast Cancer ◽  
Human Breast ◽  
P Glycoprotein ◽  
Mcf 7

Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells

2017 ◽  
Vol 213 (7) ◽  
pp. 848-853 ◽  
Author(s):  
Chun Li ◽  
Xingang Guan ◽  
Haogang Xue ◽  
Peng Wang ◽  
Manli Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
P Glycoprotein ◽  
Mcf 7

scholarly journals Diltiazem potentiation of doxorubicin cytotoxicity and cellular uptake in human breast cancer cells

2019 ◽  
Vol 8 (4) ◽  
pp. BMT31
Author(s):  
Hamdan S Al-malky ◽  
Zoheir A Damanhouri ◽  
Jumana Y Al Aama ◽  
Ali A Al Qahtani ◽  
Wafaa S Ramadan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cytotoxic Activity ◽  
Cellular Uptake ◽  
Breast Cancer Cells ◽  
Limiting Factors ◽  
Human Breast ◽  
Common Cancer ◽  
P Glycoprotein ◽  
Mcf 7

Aim: Breast cancer is the most common cancer among Arab women and also around the world. Chronic cardiotoxicity and multidrug resistance are potential limiting factors of doxorubicin (DOX), a known anthracycline antibiotic. Materials & methods: DOX cytotoxicity was evaluated by the sulforhodamine method. DOX cellular uptake, detection of P-glycoprotein activity and the photomicrograph of MCF-7 cells were also determined. Results: Diltiazem (DIL) treatment improved DOX cytotoxic activity and increased the cellular uptake of DOX significantly and aggregation of rhodamine 123, reflecting inhibition of P-glycoprotein pump. Cytopathological investigation of MCF-7 cells revealed marked cytotoxic activity of DOX in the presence of DIL. Conclusion: DIL treatment enhanced DOX cytotoxic effect and reduced multidrug resistance, which increased the drug accumulation intracellularly.

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