Blighia sapida leaves halt elevated blood glucose, dyslipidemia and oxidative stress in alloxan-induced diabetic rats

Background: The ethanomedicinal importance of Moringa concanensis Nimmo plant is reflected in Ayurvedic and traditional system of medicine. It brings out its importance as diverse plant in Ayurvedic preparation and diabetes management. Aims of study: The research was centred to bring out the Hyperglycemiccapabilities of Moringa concanensis Nimmo leaves Ethanolic extract (PE) on Alloxan monohydrate (AXM) induceddiabetic rat model. Materials and Methods: Wistar rats were made diabetic by AXM and treated with PE (200 mg/kg body weight) and glibenclamide as a standard drug. All Essential parameters like Fasting blood glucose (FBS), Post prandial blood glucose (PPBS), AST, ALT, ALP, ACP, LDH and oxidative stress markers were measured. Also to see β-cells structures histology of pancreas was also done. Results: The non toxicity of PE dose was confirmed by acute toxicity study and also this study models helped to know about the anti-hyperglycemic effects of PE by decreasing FBS and PPBS levels in the diabetic rats. It also enhances oxidative stress by decreasing MDA levels and elevating the GSH and SOD. The histopathological analysis helped us to know about structure decay of β-cells of pancreas tissue of diabetic rats. PEpotential was confirmed by serum enzymes AST, ALT, ALP, ACP and LDH as it showed significant decrease in diabetic rats. Conclusion: It was confirmed from the data that PE is efficient in governance of diabetes and its control, so there is a need to work at molecular level to bring out all its potential for the benefit of the society.

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ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF LYGODIUM MICROPHYLLUM IN ALLOXAN INDUCED DIABETIC RATS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2018v10i12.29232 ◽

2018 ◽

Vol 10 (12) ◽

pp. 75

Author(s):

D. G. Syahidah Nadiah Binti Abdull Majid ◽

Mohammad Iqbal

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

Control Group ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Antioxidative Effects ◽

And Oxidative Stress

Objective: The antihyperglycemic and antioxidative effects of L. microphyllum were evaluated by using in vivo methods in normal and alloxan induced diabetic rats.Methods: Diabetes was induced in Sprague Dawley rats by injecting alloxan through intravenous (i. v) at a dose of 100 mg/kg of body weight. Aqueous extract of L. microphyllum at different doses (400, 200 and 100 mg/kg of body weight) was administered orally (orogastric intubation) for 14 d. Blood glucose and oxidative stress markers were measured. Hematoxylin and eosin staining method were used to examine the pancreatic tissues.Results: At the 14 d interval, fasting blood glucose showed a reduction in serum glucose levels in animals pretreated with L. microphyllum compared with alloxan alone treated group. Oxidative stress was noticed in rat’s pancreatic tissue as evidenced by a significant decrease in glutathione level, glutathione reductase, glutathione-S-transferase, and catalase activities. Malondialdehyde showed a significant increase compared to the normal saline-treated control group. Serum biochemistry and oxidative stress markers were consistent with the pancreatic histopathological studies. Treatment of diabetic rats with L. microphyllum at a dose level of 100, 200 and 400 mg/kg body weight leaves extract for 14 d significantly prevented these alterations and attenuated alloxan-induced oxidative stress (P<0.05).Conclusion: The results of the present study indicated that the antihyperglycemic potential of L. microphyllum might be ascribable to its antioxidant and free radical scavenging properties. Thus, it is concluded that L. microphyllum may be helpful in the prevention of diabetic complications associated with oxidative stress.

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Investigations on the correlation of advanced glycated end products (AGE) associated fluorescence with blood glucose and oxidative stress in ethanol-administered diabetic rats

Experimental and Toxicologic Pathology ◽

10.1016/j.etp.2009.03.004 ◽

2010 ◽

Vol 62 (2) ◽

pp. 157-162 ◽

Cited By ~ 7

Author(s):

V. Renju Gopal ◽

M. Indira

Keyword(s):

Oxidative Stress ◽

Blood Glucose ◽

Diabetic Rats ◽

End Products ◽

And Oxidative Stress

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Impact Of Administration Mulberry Juice On Blood Glucose, Lipid Profile And Oxidative Stress In Normal And Diabetic Rats

Egyptian Journal of Biochemistry and Molecular Biology ◽

10.4314/ejbmb.v27i2.49253 ◽

2010 ◽

Vol 27 (2) ◽

Author(s):

FA Khalil

Keyword(s):

Oxidative Stress ◽

Blood Glucose ◽

Lipid Profile ◽

Diabetic Rats ◽

Mulberry Juice ◽

And Oxidative Stress

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l-Cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-κB activation in the livers of Zucker diabetic rats

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2009.03.014 ◽

2009 ◽

Vol 46 (12) ◽

pp. 1633-1638 ◽

Cited By ~ 55

Author(s):

Sushil K. Jain ◽

Thirunavukkarasu Velusamy ◽

Jennifer L. Croad ◽

Justin L. Rains ◽

Rebeca Bull

Keyword(s):

Oxidative Stress ◽

Blood Glucose ◽

Glycated Hemoglobin ◽

Diabetic Rats ◽

And Oxidative Stress

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Effect of Pongamia pinnata flowers on blood glucose and oxidative stress in alloxan induced diabetic rats

Indian Journal of Pharmacology ◽

10.4103/0253-7613.19858 ◽

2006 ◽

Vol 38 (1) ◽

pp. 62 ◽

Cited By ~ 17

Author(s):

S Manoharan ◽

R Punitha ◽

K Vasudevan

Keyword(s):

Oxidative Stress ◽

Blood Glucose ◽

Diabetic Rats ◽

Pongamia Pinnata ◽

And Oxidative Stress

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Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2018-0140 ◽

2019 ◽

Vol 30 (4) ◽

Cited By ~ 3

Author(s):

Praveen K. Kodumuri ◽

Christofer Thomas ◽

Raghu Jetti ◽

Anil Kumar Pandey

Keyword(s):

Oxidative Stress ◽

Blood Glucose ◽

Cognitive Dysfunction ◽

Memory Impairment ◽

Neuronal Loss ◽

Diabetic Rats ◽

Seed Extract ◽

Glucose Levels ◽

Blood Glucose Levels ◽

And Oxidative Stress

Abstract Background Natural medicinal plants have been the focus of current research for developing neuroprotective agents to be used in the diabetes-linked cognitive dysfunction. Trigonella foenum-graecum seeds (known as fenugreek, methi in Hindi), is a well-known traditional medicinal herb and possesses anti-diabetic, anti-oxidant, and anti-inflammatory properties. Purpose This study was undertaken to explore the ameliorative effects of T. foenum-graecum seed extract on diabetes-induced cognitive dysfunction. Methods Experimental diabetes was induced by administering a single dose of streptozotocin (60 mg/kg) through intraperitoneal dose. Cognitive function was assessed using a T-maze and the Morris water maze. Lipid peroxidation levels and oxidative stress in the hippocampus was measured. Quantification of hippocampal CA1 and CA3 regions was done using cresyl violet stain. Results Diabetic rats demonstrated learning and memory impairment, which was evident from poor performance in behavioral tasks, i.e. T-maze and Morris water maze tasks. Learning and memory impairment in diabetic animals is associated with increased blood glucose levels, increased oxidative stress in the hippocampus and decreased number of neurons in the CA1 and CA3 regions of the hippocampus. The diabetic rats administered with T. foenum-graecum showed improved performance in behavioral tasks, and these changes were associated with decreased blood glucose levels, decreased oxidative stress in the hippocampus, and decreased neuronal loss from the CA1 and CA3 regions of the hippocampus. Conclusion In conclusion, administration of T. foenum-graecum seed extract ameliorates diabetes-linked cognitive dysfunction in rats by decreasing blood glucose levels, reducing lipid peroxidation and oxidative stress in the hippocampus, and preventing neuronal loss from the hippocampus.

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The Effect of Chilgoza Pine Nut (Pinus gerardiana Wall.) on Blood Glucose and Oxidative Stress in Diabetic Rats

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s250464 ◽

2020 ◽

Vol Volume 13 ◽

pp. 2399-2408

Author(s):

Seyed Ahmad Hosseini ◽

Maryam Vali ◽

Mohammad Hossein Haghighi-Zade ◽

Amir Siahpoosh ◽

Reza Malihi

Keyword(s):

Oxidative Stress ◽

Blood Glucose ◽

Diabetic Rats ◽

Pine Nut ◽

And Oxidative Stress ◽

Pinus Gerardiana

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Evaluation of 4-methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid against hyperglycemia, insulin sensitivity, and oxidative stress-induced inflammatory responses and β-cell damage in the pancreas of streptozotocin-induced diabetic rats

Human & Experimental Toxicology ◽

10.1177/0960327117692133 ◽

2017 ◽

Vol 37 (2) ◽

pp. 163-174 ◽

Cited By ~ 1

Author(s):

YN Paudel ◽

MR Ali ◽

S Bawa ◽

S Shah ◽

M Adil ◽

...

Keyword(s):

Oxidative Stress ◽

Blood Glucose ◽

Insulin Sensitivity ◽

Carboxylic Acid ◽

Inflammatory Mediators ◽

Antioxidant Status ◽

Insulin Level ◽

Pancreatic Tissue ◽

Diabetic Rats ◽

And Oxidative Stress

4-Methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid (bioactive compound (BAC)), a novel thiazole derivative, is a xanthine oxidase inhibitor and free radical scavenging agent. Effects of BAC on hyperglycemia, insulin sensitivity, oxidative stress, and inflammatory mediators were evaluated in streptozotocin (STZ)-induced neonatal models of non-insulin-dependent diabetes mellitus (NIDDM) rats where NIDDM was induced in neonatal pups with single intraperitoneal injection of STZ (100 mg/kg). The effect of BAC (10 and 20 mg/kg, p.o.) for 3 weeks was evaluated by the determination of blood glucose, oral glucose tolerance test (OGTT), HbA1c level, insulin level, insulin sensitivity, and insulin resistance (IR). Furthermore, inflammatory mediators (tumor necrosis factor-alpha and interleukin-6) and oxidative stress were estimated in serum and pancreatic tissue, respectively. Significant alteration in the level of blood glucose, OGTT, HbA1c, insulin level, insulin sensitivity, in addition variation in the antioxidant status and inflammatory mediators, and alteration in histoarchitecture of pancreatic tissue confirmed the potential of BAC in STZ-induced neonatal models of NIDDM rats. Pretreatment with BAC restored the level of glucose by decreasing the IR and increasing the insulin sensitivity. Furthermore, BAC balanced the antioxidant status and preserved the inflammatory mediators. Histological studies of pancreatic tissues showed normal architecture after BAC administration to diabetic rats. Altogether, our results suggest that BAC successfully reduces the blood glucose level and possesses antioxidant as well as anti-inflammatory activities. This leads to decreased histological damage in diabetic pancreatic tissues, suggesting the possibility of future diabetes treatments.

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