Perilla frutescens leaves extract ameliorates ultraviolet radiation-induced extracellular matrix damage in human dermal fibroblasts and hairless mice skin

2017 ◽  
Vol 195 ◽  
pp. 334-342 ◽  
Author(s):  
Jung-Soo Bae ◽  
Mira Han ◽  
Hee Soon Shin ◽  
Min-Kyoung Kim ◽  
Chang-Yup Shin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Ultraviolet Radiation ◽  
Dermal Fibroblasts ◽  
Perilla Frutescens ◽  
Human Dermal Fibroblasts ◽  
Hairless Mice ◽  
Radiation Induced ◽  
Matrix Damage

scholarly journals AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Serban Iren Andreea ◽  
Costache Marieta ◽  
Dinischiotu Anca
Keyword(s):  
Extracellular Matrix ◽  
High Glucose ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Dependent Manner ◽  
Human Dermal Fibroblasts ◽  
Mrna Synthesis ◽  
Quantitative Real Time Pcr ◽  
Glucose Levels ◽  
Dose Dependent

In the dermis, fibroblasts play an important role in the turnover of the dermal extracellular matrix. Collagen I and III, the most important dermal proteins of the extracellular matrix, are progressively altered during ageing and diabetes. For mimicking diabetic conditions, the cultured human dermal fibroblasts were incubated with increasing amounts of AGE-modified BSA andD-glucose for 24 hours. The expression of procollagenα2(I) and procollagenα1(III) mRNA was analyzed by quantitative real-time PCR. Our data revealed that the treatment of fibroblasts with AGE-modified BSA upregulated the expression of procollagenα2(I) and procollagenα1(III) mRNA in a dose-dependent manner. High glucose levels mildly induced a profibrogenic pattern, increasing the procollagenα2(I) mRNA expression whereas there was a downregulation tendency of procollagenα1(III) mRNA.

scholarly journals Hydrolyzed eggshell membrane immobilized on phosphorylcholine polymer supplies extracellular matrix environment for human dermal fibroblasts

2011 ◽  
Vol 345 (1) ◽  
pp. 177-190 ◽  
Author(s):  
Eri Ohto-Fujita ◽  
Tomohiro Konno ◽  
Miho Shimizu ◽  
Kazuhiko Ishihara ◽  
Toshihiro Sugitate ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Dermal Fibroblasts ◽  
Eggshell Membrane ◽  
Human Dermal Fibroblasts

Modulation by hypergravity of extracellular matrix macromolecules in in vitro human dermal fibroblasts

1995 ◽  
Vol 1245 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Yolande Gaubin ◽  
Bernadette Pianezzi ◽  
Jean-Pierre Soleilhavoup ◽  
Françoise Croute
Keyword(s):  
Extracellular Matrix ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts

scholarly journals Ultraviolet Radiation-Induced Connective Tissue Changes in the Skin of Hairless Mice

1984 ◽  
Vol 82 (6) ◽  
pp. 587-590 ◽  
Author(s):  
Kathryn J Johnston ◽  
Aarne I. Oikarinen ◽  
Nicholas J Lowe ◽  
Joan G Clark ◽  
Jouni Uitto
Keyword(s):  
Connective Tissue ◽  
Ultraviolet Radiation ◽  
Hairless Mice ◽  
Tissue Changes ◽  
Radiation Induced
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