Characterization of a protein-bound polysaccharide from Herba Epimedii and its metabolic mechanism in chronic fatigue syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystemic disorder responsible for significant disability. Although a unifying etiology for ME/CFS is uncertain, impaired natural killer (NK) cell cytotoxicity represents a consistent and measurable feature of this disorder. Research utilizing patient-derived NK cells has implicated dysregulated calcium (Ca2+) signaling, dysfunction of the phosphatidylinositol-4,5-bisphosphate (PIP2)-dependent cation channel, transient receptor potential melastatin (TRPM) 3, as well as altered surface expression patterns of TRPM3 and TRPM2 in the pathophysiology of ME/CFS. TRPM7 is a related channel that is modulated by PIP2 and participates in Ca2+ signaling. Though TRPM7 is expressed on NK cells, the role of TRPM7 with IL-2 and intracellular signaling mechanisms in the NK cells of ME/CFS patients is unknown. This study examined the effect of IL-2 stimulation and TRPM7 pharmacomodulation on NK cell cytotoxicity using flow cytometric assays as well as co-localization of TRPM7 with PIP2 and cortical actin using confocal microscopy in 17 ME/CFS patients and 17 age- and sex-matched healthy controls. The outcomes of this investigation are preliminary and indicate that crosstalk between IL-2 and TRMP7 exists. A larger sample size to confirm these findings and characterization of TRPM7 in ME/CFS using other experimental modalities are warranted.

Download Full-text

Clinical and Pathogenetical Characterization of 238 Patients of a Chronic Fatigue Syndrome Italian Center

Journal of Chronic Fatigue Syndrome ◽

10.1300/j092v05n03_05 ◽

1999 ◽

Vol 5 (3-4) ◽

pp. 61-70 ◽

Cited By ~ 1

Author(s):

Delia Racciatti ◽

Annamaria Barberio ◽

Jacopo Vecchiet ◽

Eligio Pizzigallo

Keyword(s):

Chronic Fatigue Syndrome ◽

Chronic Fatigue ◽

Fatigue Syndrome

Download Full-text

Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

Clinical Science ◽

10.1042/cs19990155 ◽

1999 ◽

Vol 97 (3) ◽

pp. 319 ◽

Cited By ~ 1

Author(s):

D.A. DUPREZ ◽

M.L. DE BUYZERE ◽

B. DRIEGHE ◽

F. VANHAVERBEKE ◽

Y. TAES ◽

...

Keyword(s):

Blood Pressure ◽

Chronic Fatigue Syndrome ◽

Chronic Fatigue ◽

Short Term ◽

Fatigue Syndrome

Download Full-text

Diagnostic Concordance Between Categorical and Dimensional Instruments to Assess Personality Disorder in Chronic Fatigue Syndrome

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000281 ◽

2017 ◽

Vol 33 (3) ◽

pp. 158-165

Author(s):

Natalia Calvo ◽

Naia Sáez-Francàs ◽

Sergi Valero ◽

Jesús Castro-Marrero ◽

José Alegre Martín ◽

...

Keyword(s):

Personality Disorder ◽

Chronic Fatigue Syndrome ◽

Personality Assessment ◽

Chronic Fatigue ◽

Specific Pattern ◽

Harm Avoidance ◽

Assessment Instrument ◽

Compulsive Disorder ◽

Fatigue Syndrome ◽

Self Transcendence

Abstract. The study examines the relationship between a categorical and a dimensional personality assessment instrument in patients with Chronic Fatigue Syndrome (CFS). A total of 162 CFS patients were included in the study (91.4% women; mean age 47.5 years). All subjects completed the Spanish versions of the Personality Diagnostic Questionnaire-4+ (PDQ-4+) and the Temperament and Character Inventory-Revised (TCI-R). Results: 78 (48.1%) of the patients presented a Personality Disorder (PD), the most frequent being Cluster C, specifically Obsessive-compulsive disorder, followed by Avoidant disorder. PDs showed a specific pattern of correlation with temperament scales. All PD clusters correlated positively with Harm Avoidance and Self-Transcendence, and negatively with Reward Dependence, Self-Directedness, and Cooperativeness. In a logistic regression analysis, Self-Directedness and Cooperativeness predicted PD presence. The findings are consistent with previous studies in non-CFS samples and suggest that the combination of the Temperament and Character dimensions (low Self-Directedness and Cooperativeness and high Harm Avoidance and Self-Transcendence) correlates with PD severity, and that Self-Directedness and Cooperativeness are associated with PD presence in CFS patients. The integration of these two perspectives expands the current comprehension of personality pathology in CFS patients.

Download Full-text