Substituting one Paris for another? In vitro cytotoxic and in vivo antitumor activities of Paris forrestii , a substitute of Paris polyphylla var. yunnanensis

2018 ◽  
Vol 218 ◽  
pp. 45-50 ◽  
Author(s):  
Yue-Hu Wang ◽  
Min Shi ◽  
Hong-Mei Niu ◽  
Jun Yang ◽  
Meng-Yuan Xia ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Paris Polyphylla

Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo

2011 ◽  
Vol 137 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Judy Yuet-Wa Chan ◽  
Johnny Chi-Man Koon ◽  
Xiaozhou Liu ◽  
Michael Detmar ◽  
Biao Yu ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Zebrafish Embryos ◽  
Steroidal Saponin ◽  
Cell Functions ◽  
Paris Polyphylla ◽  
Polyphyllin D

scholarly journals Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107 III. In Vitro and In Vivo Antitumor Activities

2004 ◽  
Vol 57 (3) ◽  
pp. 188-196 ◽  
Author(s):  
YOSHIHARU MIZUI ◽  
TAKASHI SAKAI ◽  
MASAO IWATA ◽  
TOSHIMITSU UENAKA ◽  
KIYOSHI OKAMOTO ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Streptomyces Platensis

A supramolecular adduct of tegafur and syringic acid: the first tegafur-nutraceutical cocrystal with perfected in vitro and in vivo characteristics as well as synergized anticancer activities

2020 ◽  
Vol 44 (37) ◽  
pp. 15994-16005
Author(s):  
Yue-Ming Yu ◽  
Ming-Chao Yu ◽  
Ling-Yang Wang ◽  
Yan-Tuan Li ◽  
Zhi-Yong Wu ◽  
...  
Keyword(s):  
Syringic Acid ◽  
Anticancer Activities ◽  
Antitumor Activities ◽  
Supramolecular Adduct

The in vitro and in vivo properties as well as synergistic antitumor activities of the first tegafur-nutraceutical cocrystal are reported.

Antitumor Activities of Extracts and Compounds from Water Decoctions of Taxus cuspidata

2010 ◽  
Vol 38 (06) ◽  
pp. 1107-1114 ◽  
Author(s):  
Shougang Jiang ◽  
Yu Zhang ◽  
Yuangang Zu ◽  
Zhuo Wang ◽  
Yujie Fu
Keyword(s):  
Antitumor Activity ◽  
Water Soluble ◽  
Taxus Cuspidata ◽  
Antitumor Activities ◽  
Antitumor Effects ◽  
Anticancer Properties ◽  
Specific Host ◽  
First Time

Water decoctions from the leaves of Taxus cuspidata are used in traditional Chinese medicine to treat cancer, suggesting that water soluble constituents from these leaves may possess anticancer properties. Interestingly, hydrophilic paclitaxel derivatives, as opposed to paclitaxel itself, can be detected by high pressure liquid chromatography in water decoctions from these leaves. The remainder extracts, which are free of paclitaxel and hydrophilic paclitaxel derivatives, from the T. cuspidata leaves were investigated for antitumor activity in vivo and in vitro for the first time in this study. EE80B, 7-xylosyl-10-deacetylpaclitaxel and 7-xylosyl-10-deacetylpaclitaxel C displayed the most antitumor activity in vivo. However, in vitro studies with tumor cell lines showed that EE80B had a significantly smaller antitumor effect than paclitaxel. We hypothesize that water decoctions from T. cuspidata leaves exhibit antitumor effects in vivo, which may be aided by the activation of specific host mechanisms (e.g. stimulation of antitumor immunity) which are not present in vitro.

Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines

2013 ◽  
Vol 60 ◽  
pp. 10-22 ◽  
Author(s):  
Buxi Shi ◽  
Rihui Cao ◽  
Wenxi Fan ◽  
Liang Guo ◽  
Qin Ma ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Design Synthesis

Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107. Part 3. In vitro and in vivo Antitumor Activities.

ChemInform ◽  
2004 ◽  
Vol 35 (31) ◽  
Author(s):  
Yoshiharu Mizui ◽  
Takashi Sakai ◽  
Masao Iwata ◽  
Toshimitsu Uenaka ◽  
Kiyoshi Okamoto ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Streptomyces Platensis

Enhanced antitumor activities of (−)-epigallocatechin-3-O-gallate fatty acid monoester derivatives in vitro and in vivo

2008 ◽  
Vol 377 (4) ◽  
pp. 1118-1122 ◽  
Author(s):  
Kazuaki Matsumura ◽  
Kunihiro Kaihatsu ◽  
Shuichi Mori ◽  
Han Hee Cho ◽  
Nobuo Kato ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Antitumor Activities ◽  
Fatty Acid Monoester

scholarly journals Histone Deacetylase Inhibitors with Enhanced Enzymatic Inhibition Effects and Potent in vitro and in vivo Antitumor Activities

ChemMedChem ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 638-648 ◽  
Author(s):  
Lei Zhang ◽  
Yingjie Zhang ◽  
C. James Chou ◽  
Elizabeth S. Inks ◽  
Xuejian Wang ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Antitumor Activities ◽  
Enzymatic Inhibition
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