Integration of organ metabolomics and proteomics in exploring the blood enriching mechanism of Danggui Buxue Decoction in hemorrhagic anemia rats

2020 ◽  
Vol 261 ◽  
pp. 113000
Author(s):  
Xu-Qin Shi ◽  
Zhen-Hua Zhu ◽  
Shi-Jun Yue ◽  
Yu-Ping Tang ◽  
Yan-Yan Chen ◽  
...  
Keyword(s):  
Danggui Buxue Decoction

scholarly journals Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X-Irradiation-Induced Cardiac Fibrosis in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Chengxu Ma ◽  
Xinke Zhao ◽  
Juan Chang ◽  
Huan Guo ◽  
Huiping Wei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Fibrosis ◽  
Cardiac Fibrosis ◽  
Cardiac Fibroblasts ◽  
Angelica Sinensis ◽  
X Irradiation ◽  
Radiation Induced ◽  
Induction Of Apoptosis ◽  
Stress Damage ◽  
Danggui Buxue Decoction

Radiation-induced myocardial fibrosis (RIMF) is the main pathological change associated with radiation-induced heart toxicity after radiation therapy in patients with thoracic tumors. There is an antifibrosis effect of Radix Angelica Sinensis and Radix Hedysari (RAS-RH) ultrafiltration extract from Danggui Buxue decoction (DBD) in X-irradiation-induced rat myocardial fibrosis, and this study aimed to investigate whether that effect correlated with apoptosis and oxidative stress damage in primary rat cardiac fibroblasts; further, the potential mechanisms were also explored. In this study, we first found that the RAS-RH antifibrosis effect was associated with the upregulation of microRNA-200a and the downregulation of TGF-β1/smad3 and COL1α. In addition, we also found that the antifibrosis effect of RAS-RH was related to the induction of apoptosis in primary rat cardiac fibroblasts and to the prevention of damage caused by reactive oxygen species (ROS). Interestingly, primary rat cardiac fibroblasts exposed to X-ray radiation underwent apoptosis less frequently in the absence of RAS-RH. Therefore, RAS-RH has the ability to protect against fibrosis, which could be occurring through the induction of apoptosis and the resistance to oxidative stress in rats with X-irradiation-induced myocardial fibrosis; thus, in a model of RIMF, RAS-RH acts against X-irradiation-induced cardiac toxicity.

Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC–DAD–MS

2007 ◽  
Vol 852 (1-2) ◽  
pp. 598-604 ◽  
Author(s):  
Xiao-Dong Wen ◽  
Lian-Wen Qi ◽  
Jun Chen ◽  
Yue Song ◽  
Ling Yi ◽  
...  
Keyword(s):  
Bioactive Components ◽  
Danggui Buxue Decoction

A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction

2019 ◽  
Vol 235 ◽  
pp. 227-242 ◽  
Author(s):  
Xu-Qin Shi ◽  
Shi-Jun Yue ◽  
Yu-Ping Tang ◽  
Yan-Yan Chen ◽  
Gui-Sheng Zhou ◽  
...  
Keyword(s):  
Network Pharmacology ◽  
Danggui Buxue Decoction
Sign in / Sign up

Export Citation Format

Share Document