Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation

2021 ◽  
Vol 19 (6) ◽  
pp. 422-431
Author(s):  
Xu-Qin SHI ◽  
Zhen-Hua ZHU ◽  
Shi-Jun YUE ◽  
Yu-Ping TANG ◽  
Yan-Yan CHEN ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gut Microbiota ◽  
Danggui Buxue Decoction ◽  
Cancer Related Anemia

scholarly journals Probiotics and Colon Cancer

2019 ◽  
Vol 7 (3) ◽  
pp. 66 ◽  
Author(s):  
Lorenzo Drago
Keyword(s):  
Colon Cancer ◽  
Radiation Therapy ◽  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Immune Modulation ◽  
Average Frequency ◽  
Scientific Interest ◽  
Positive Action ◽  
Bowel Movements ◽  
The Relationship

Literature has recently highlighted the enormous scientific interest on the relationship between the gut microbiota and colon cancer, and how the use of some selected probiotics can have a future impact on the adverse events which occur during this disease. Although there is no clear evidence to claim that probiotics are effective in people with cancer, recent reviews have found that probiotics can significantly reduce the incidence of diarrhea and the average frequency of daily bowel movements. However, most of this evidence needs to be more clinically convincing and further discussed. Undoubtedly, some probiotics, when properly dosed and administered, can have a strong rebalance effect on the gut microbiota and as a consequence a possible positive action on immune modulation of the gastrointestinal tract and on inflammation of the intestinal mucosa. Many recent findings indeed support the hypothesis that the daily use of some selected probiotics can be a feasible approach to effectively protect patients against the risk of some severe consequences due to radiation therapy or chemotherapy. This paper aims to review the most recent articles in order to consider a possible adjuvant approach for the use of certain well-balanced probiotics to help prevent colon cancer and the adverse effects caused by related therapies.

scholarly journals The Wnt–β-Catenin–IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota

2020 ◽  
Vol 205 (8) ◽  
pp. 2265-2275
Author(s):  
Daniel Swafford ◽  
Arulkumaran Shanmugam ◽  
Punithavathi Ranganathan ◽  
Indumathi Manoharan ◽  
Mohamed S. Hussein ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gut Microbiota ◽  
Signaling Axis

scholarly journals Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Shichang Bian ◽  
Hongjuan Wan ◽  
Xinyan Liao ◽  
Weisheng Wang
Keyword(s):  
Colon Cancer ◽  
Treatment Group ◽  
16S Rrna ◽  
Gut Microbiota ◽  
High Throughput Sequencing ◽  
Potential Mechanism ◽  
Inhibitory Effects ◽  
Antitumor Effects

The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’s potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by apigenin. Further experiments in which gut microbiota were reduced and feces were transplanted provided further evidence of apigenin-modulated gut microbiota exerting antitumor effects. Apigenin was unable to reduce the number or size of tumors when gut microbiota were depleted. Moreover, tumor inhibition effects were initiated following the transplant of feces from mice treated with apigenin. Our findings suggest that the effect of apigenin on the composition of gut microbiota can suppress tumors.

628 – Identification of Crosstalk Between Gut Microbiota, Ceacams, and TGF-Β Signaling in Processing Chemotherapy Response in Colon Cancer

2019 ◽  
Vol 156 (6) ◽  
pp. S-132
Author(s):  
Shoujun Gu ◽  
Shuyun Rao ◽  
Charles H. King ◽  
Yunxiao Meng ◽  
Wilma Jogunoori ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gut Microbiota ◽  
Chemotherapy Response

scholarly journals Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk

2017 ◽  
Vol 46 ◽  
pp. 191-204 ◽  
Author(s):  
Derek V. Seidel ◽  
M. Andrea Azcárate-Peril ◽  
Robert S. Chapkin ◽  
Nancy D. Turner
Keyword(s):  
Colon Cancer ◽  
Cancer Risk ◽  
Gut Microbiota ◽  
Colon Cancer Risk

scholarly journals The Role of the Gut Microbiome in Colorectal Cancer

2018 ◽  
Vol 31 (03) ◽  
pp. 192-198 ◽  
Author(s):  
Grace Chen
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Microbial Community ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Intestinal Health ◽  
Genotoxic Effects ◽  
Bacterial Populations ◽  
Health And Disease

AbstractThere is increasing evidence that the gut microbiome, which consists of trillions of microbes representing over 1,000 species of bacteria with over 3 million genes, significantly impacts intestinal health and disease. The gut microbiota not only is capable of promoting intestinal homeostasis and antitumor responses but can also contribute to chronic dysregulated inflammation as well as have genotoxic effects that lead to carcinogenesis. Whether the gut microbiota maintains health or promotes colon cancer may ultimately depend on the composition of the gut microbiome and the balance within the microbial community of protective and detrimental bacterial populations. Disturbances in the normal balanced state of a healthful microbiome, known as dysbiosis, have been observed in patients with colorectal cancer (CRC); however, whether these alterations precede and cause CRC remains to be determined. Nonetheless, studies in mice strongly suggest that the gut microbiota can modulate susceptibility to CRC, and therefore may serve as both biomarkers and therapeutic targets.

scholarly journals Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer

2018 ◽  
Vol 34 (6) ◽  
pp. 280-285 ◽  
Author(s):  
Kwangmin Kim ◽  
Ernes John T. Castro ◽  
Hongjin Shim ◽  
John Vincent G. Advincula ◽  
Young-Wan Kim
Keyword(s):  
Colon Cancer ◽  
Gut Microbiota ◽  
Left Colon ◽  
Molecular Features ◽  
Left Colon Cancer

scholarly journals Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 900 ◽  
Author(s):  
Alyssa A. Leystra ◽  
Margie L. Clapper
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Experimental Design ◽  
Gut Microbiota ◽  
Mouse Models ◽  
Therapeutic Strategies ◽  
Response To Therapy ◽  
Valuable Resource ◽  
Disease Phenotypes ◽  
Experimental Findings

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Mouse models are a valuable resource for use throughout the development and testing of new therapeutic strategies for CRC. Tumorigenesis and response to therapy in humans and mouse models alike are influenced by the microbial communities that colonize the gut. Differences in the composition of the gut microbiota can confound experimental findings and reduce the replicability and translatability of the resulting data. Despite this, the contribution of resident microbiota to preclinical tumor models is often underappreciated. This review does the following: (1) summarizes evidence that the gut microbiota influence CRC disease phenotypes; (2) outlines factors that can influence the composition of the gut microbiota; and (3) provides strategies that can be incorporated into the experimental design, to account for the influence of the microbiota on intestinal phenotypes in mouse models of CRC. Through careful experimental design and documentation, mouse models can continue to rapidly advance efforts to prevent and treat colon cancer.

scholarly journals The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Tianqing Sang ◽  
Wenli Qiu ◽  
Wenting Li ◽  
Hongli Zhou ◽  
Haibin Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Clinical Practice ◽  
Gut Microbiota ◽  
Malignant Tumors ◽  
Tumor Development ◽  
Technological Advances ◽  
Herbal Compound ◽  
Chinese Herbal Compound ◽  
The Relationship

Gut microbiota is a diverse consortium of bacteria, fungi, protozoa, and viruses in the gut of all mammals. Gut microbiota remains in steady state under normal conditions. Changes in the internal and external environment may cause gut Microbiota to be out of tune. Malignant tumors are one of the major diseases currently endangering human health. CRC (colorectal cancer) has a significant upward trend in morbidity and mortality in many parts of the world. Technological advances have not yet brought about a breakthrough in the efficacy of CRC. The development of colon cancer is closely related to gut microbiota imbalance. According to more than 60 years of clinical practice, Professor Zhongying Zhou first proposed the pathogenesis theory of “cancerous toxin” in the 1990s and believed that cancerous toxin was a key pathogenesis of tumor development. Under the guidance of the theory of cancerous toxin, combined with clinical practice, Professor Zhou created an effective anticancer Chinese herbal compound, Jiedu Xiaoai Prescription. This paper summarizes recent hotspots related to gut microbiota and the occurrence, development, and prevention of colon cancer at home and abroad. The relationship between gut microbiota and cancerous toxin theory is proposed, and the feasibility of further studying the biological basis of cancerous toxin pathogenesis theory from the perspective of gut microbiota is pointed out.

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