Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats

Introduction: Trypanosoma cruzi is the agent of Chagas’ disease and affects approximately 6-8 million people worldwide. The search for new anti-T. cruzi drugs are relevant because only two drugs exist actually. The objective of this study was to investigate the effect of the extracts from the seeds of Lonchocarpus cultratus on T. cruzi, its cytotoxicity as well as to elucidate its chemical profile. Methodology: The characterization of the extracts was done using 1H-RMN. T. cruzi forms were treated with increasing concentrations of the extracts and after, the percentage of inhibition and IC50 or LC50 were calculated. Murine peritoneal macrophages were treated with different concentrations of the extracts to evaluate the cellular viability. The hemotoxicity was accessed by verifying the levels of hemolysis caused by the extracts on human red blood cells. Results: Chalcones isocordoin and lonchocarpin were detected in the dichloromethane extract, and chalcone lonchocarpin was detected in the hexane extract. The dichloromethane extract showed higher activity against all the forms of T. cruzi compared to the other two extracts, but the hexane showed the best selectivity index. The cytotoxicity observed in murine macrophages was confirmed in human erythrocytes, with dichloromethane extract having the highest toxicity. The methanolic extract showed the lowest anti-T. cruzi activity but was nontoxic to peritoneal murine macrophages and red blood cells. Conclusions: L. cultratus extracts have the potential to be explored for the development of new anti-trypanosomal drugs. This study was the first to demonstrate the action of extracts from the genus Lonchocarpus on infecting forms of T. cruzi.

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Chemical characterization of ginger and vinegar soaked ginger: Changes in volatiles and chemical profile

Journal of Food Processing and Preservation ◽

10.1111/jfpp.14418 ◽

2020 ◽

Vol 44 (5) ◽

Author(s):

Cheng‐piao Tian ◽

Ya‐ling Song ◽

Hai‐tang Xu ◽

Xing‐dong Yao ◽

Si‐qi Niu ◽

...

Keyword(s):

Chemical Characterization ◽

Chemical Profile

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Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats

Biochimie ◽

10.1016/j.biochi.2015.02.003 ◽

2015 ◽

Vol 111 ◽

pp. 70-81 ◽

Cited By ~ 10

Author(s):

Rangachari Balamurugan ◽

Subramanian Ezhil Vendan ◽

Adithan Aravinthan ◽

Jong-Hoon Kim

Keyword(s):

Glucose Metabolism ◽

Ethyl Acetate ◽

Structural Characterization ◽

Ethyl Acetate Extract ◽

Diabetic Rats ◽

Hypoglycemic Effect ◽

Key Enzymes

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Purification and characterization of a protein phosphatase from rat liver acting on key enzymes of glucose metabolism

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1984.tb08112.x ◽

1984 ◽

Vol 140 (2) ◽

pp. 375-383 ◽

Cited By ~ 23

Author(s):

Gottfried MIESKES ◽

Ingeborg A. BRAND ◽

Hans-Dieter SOLING

Keyword(s):

Glucose Metabolism ◽

Rat Liver ◽

Protein Phosphatase ◽

Purification And Characterization ◽

Key Enzymes

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Characterization of the mammalian DEAD-box protein DDX5 reveals functional conservation withS. cerevisiaeortholog Dbp2 in transcriptional control and glucose metabolism

RNA ◽

10.1261/rna.060335.116 ◽

2017 ◽

Vol 23 (7) ◽

pp. 1125-1138 ◽

Cited By ~ 15

Author(s):

Zheng Xing ◽

Siwen Wang ◽

Elizabeth J. Tran

Keyword(s):

Glucose Metabolism ◽

Transcriptional Control ◽

Functional Conservation ◽

Dead Box

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Molecular characterization of Dalmatian cultivars and the influence of the olive fruit harvest period on chemical profile, sensory characteristics and oil oxidative stability

European Food Research and Technology ◽

10.1007/s00217-017-2954-7 ◽

2017 ◽

Vol 244 (2) ◽

pp. 281-289 ◽

Cited By ~ 7

Author(s):

Tea Bilušić ◽

Mirella Žanetić ◽

Ivica Ljubenkov ◽

Ivana Generalić Mekinić ◽

Snježana Štambuk ◽

...

Keyword(s):

Oxidative Stability ◽

Molecular Characterization ◽

Sensory Characteristics ◽

Chemical Profile ◽

Olive Fruit ◽

Fruit Harvest

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Rapid characterization of hypanthium and seed in wild and cultivated rosehip: application of Raman microscopy combined with multivariate analysis

Royal Society Open Science ◽

10.1098/rsos.202064 ◽

2021 ◽

Vol 8 (3) ◽

Author(s):

Ilinka Pećinar ◽

Djurdja Krstić ◽

Gianluca Caruso ◽

Jelena B. Popović-Djordjević

Keyword(s):

Food Industry ◽

Abiotic Factors ◽

Storage Conditions ◽

Chemical Profile ◽

Rosa Canina ◽

Lower Extent ◽

Rapid Characterization ◽

Dog Rose ◽

And Storage

Rosehip (pseudo-fruit) of dog rose ( Rosa canina L.) is highly valued, and owing to nutritional and sensory properties it has a significant place in the food industry. This work represents an innovative report focusing on the evaluation of the phytochemical composition of rosehips (hypanthium and seed) grown in different locations in Serbia, using Raman microspectroscopy combined with multivariate data analysis. Some significant differences arose between the analysed rosehip samples with regard to the chemical profile of both hypanthium parenchyma cells and seed, although no evident discrimination was recorded between the samples of wild and cultivated rosehip. The differences between the hypanthium samples compared were mainly determined by the content of carotenoids, phenolic compounds and polysaccharides, whereas phenolics, polysaccharides (pectin, cellulose and hemicellulose) and lipids (to a lower extent) contributed to the seed sample discrimination. The differences observed between the rosehip samples may be attributed to abiotic factors (growing, ripening and storage conditions), which had a significant impact on the carotenoid and polyphenols biosynthesis.

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