Evaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays

AbstractSouth Africa contains 9% of the worldʼs higher plants, and despite its rich biodiversity, it has one of the highest prevalence of hypertension in Africa. This review provides information on medicinal plants embraced in South Africa for hypertension management, with the aim of reporting pharmacological information on the indigenous use of these plants as antihypertensives. This review not only focuses on the activity of antihypertensive medicinal plants but also reports some of its phytochemical constituents and other ethnopharmacological and therapeutic properties. Information obtained from scientific and or unpublished databases such as Science Direct, PubMed, SciFinder, JSTOR, Google Scholar, Web of Science, and various books revealed 117 documented antihypertensive plant species from 50 families. Interestingly, Asteraceae topped the list with 16 species, followed by Fabaceae with 8 species; however, only 25% of all plant species have demonstrated antihypertensive effects originating from both in vitro and in vivo studies, lending credence to their folkloric use. Only 11 plant species reportedly possess antihypertensive properties in animal models, with very few species subjected to analytical processes to reveal the identity of their bioactive antihypertensive compounds. In this review, we hope to encourage researchers and global research institutions (universities, agricultural research councils, and medical research councils), particularly those showing an interest in natural products, for the need for concerted efforts to undertake more studies aimed at revealing the untapped potential of these plants. These studies are very important for the development of new pharmaceuticals of natural origin useful for the management of hypertension.

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Wound Healing Activities and Potential of Selected African Medicinal Plants and Their Synthesized Biogenic Nanoparticles

Plants ◽

10.3390/plants10122635 ◽

2021 ◽

Vol 10 (12) ◽

pp. 2635

Author(s):

Caroline Tyavambiza ◽

Phumuzile Dube ◽

Mediline Goboza ◽

Samantha Meyer ◽

Abram Madimabe Madiehe ◽

...

Keyword(s):

Wound Healing ◽

Medicinal Plants ◽

Wound Repair ◽

Chronic Wounds ◽

In Vivo Models ◽

Repair Mechanisms ◽

Treatment Of Wounds ◽

Biogenic Nanoparticles

In Africa, medicinal plants have been traditionally used as a source of medicine for centuries. To date, African medicinal plants continue to play a significant role in the treatment of wounds. Chronic wounds are associated with severe healthcare and socio-economic burdens despite the use of conventional therapies. Emergence of novel wound healing strategies using medicinal plants in conjunction with nanotechnology has the potential to develop efficacious wound healing therapeutics with enhanced wound repair mechanisms. This review identified African medicinal plants and biogenic nanoparticles used to promote wound healing through various mechanisms including improved wound contraction and epithelialization as well as antibacterial, antioxidant and anti-inflammatory activities. To achieve this, electronic databases such as PubMed, Scifinder® and Google Scholar were used to search for medicinal plants used by the African populace that were scientifically evaluated for their wound healing activities in both in vitro and in vivo models from 2004 to 2021. Additionally, data on the wound healing mechanisms of biogenic nanoparticles synthesized using African medicinal plants is included herein. The continued scientific evaluation of wound healing African medicinal plants and the development of novel nanomaterials using these plants is imperative in a bid to alleviate the detrimental effects of chronic wounds.

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In vitro 5-Lipoxygenase and Anti-Oxidant Activities of South African Medicinal Plants Commonly Used Topically for Skin Diseases

Skin Pharmacology and Physiology ◽

10.1159/000095253 ◽

2006 ◽

Vol 19 (6) ◽

pp. 329-335 ◽

Cited By ~ 32

Author(s):

Y. Frum ◽

A.M. Viljoen

Keyword(s):

Medicinal Plants ◽

South African ◽

Skin Diseases ◽

Anti Oxidant

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Medicinal plants with wound healing potential

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v13i1.32646 ◽

2018 ◽

Vol 13 (1) ◽

pp. 41 ◽

Cited By ~ 5

Author(s):

Sayeed Mohammed Firdous ◽

Dippayan Sautya

Keyword(s):

Wound Healing ◽

Medicinal Plants ◽

Soft Tissues ◽

Therapeutic Practice ◽

Anti Oxidant ◽

Oxide Synthase ◽

Inducible Nitric Oxide

<p class="Abstract">Wound occurs due to disruption of soft tissues that results from injury. Recently many medicinal plants have been demonstrated for wound healing potential through in vivo and in vitro preclinical models and their mechanisms of wound healing has also been reported. Medicinal plants have been reported to show wound healing potential via angiogenesis, activation of NF-κB, favoring pro-inflammatory cytokines, increased expression of inducible nitric oxide synthase (iNOS) and alpha 1 type 1 collagen, and anti-oxidant activity. Thus, in this review, an attempt was made to give an insight into the recently reported medicinal plants with wound healing mechanisms which could be beneficial in therapeutic practice and development of new wound healing drugs for human use.</p>

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Determination of the Wound Healing Potentials of Medicinal Plants Historically Used in Ghana

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/9480791 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Sara H. Freiesleben ◽

Jens Soelberg ◽

Nils T. Nyberg ◽

Anna K. Jäger

Keyword(s):

Wound Healing ◽

Medicinal Plants ◽

Plant Species ◽

Cold Water ◽

Water Extract ◽

Scratch Assay ◽

3T3 Fibroblasts ◽

Nih 3T3 ◽

Wound Healing Activity

The present study was carried out to investigate the wound healing potentials of 17 medicinal plants historically used in Ghana for wound healing. Warm and cold water extracts were prepared from the 17 dried plant species and tested in vitro in the scratch assay with NIH 3T3 fibroblasts from mice. The wound healing scratch assay was used to evaluate the effect of the plants on cell proliferation and/or migration in vitro, as a test for potential wound healing properties. After 21 hours of incubation increased proliferation and/or migration of fibroblasts in the scratch assay was obtained for 5 out of the 17 plant species. HPLC separation of the most active plant extract, which was a warm water extract of Philenoptera cyanescens, revealed the wound healing activity to be attributed to rutin and a triglycoside of quercetin. The present study suggests that Allophylus spicatus, Philenoptera cyanescens, Melanthera scandens, Ocimum gratissimum, and Jasminum dichotomum have wound healing activity in vitro.

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In vitro antifungal activity of some South African medicinal plants

South African Journal of Botany ◽

10.1016/s0254-6299(15)30444-0 ◽

2002 ◽

Vol 68 (1) ◽

pp. 72-76 ◽

Cited By ~ 16

Author(s):

A.J. Afolayan ◽

D.S. Grierson ◽

L. Kambizi ◽

I. Madamombe ◽

P.J. Masika ◽

...

Keyword(s):

Antifungal Activity ◽

Medicinal Plants ◽

South African ◽

In Vitro Antifungal Activity

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Ethiopian medicinal plants used for their anti-inflammatory, wound healing or anti-infective activities: protocol for systematic literature review and meta-analysis

BMJ Open Science ◽

10.1136/bmjos-2020-100064 ◽

2020 ◽

Vol 4 (1) ◽

pp. e100064

Author(s):

Dereje Nigussie ◽

Belete Adefris Legesse ◽

Gail Davey ◽

Abebaw Fekadu ◽

Eyasu Makonnen

Keyword(s):

Systematic Review ◽

Wound Healing ◽

Medicinal Plants ◽

Literature Review ◽

Plant Species ◽

Systematic Literature Review ◽

Meta Analysis ◽

Registration Number ◽

Anti Inflammatory

ObjectivesMedicinal plants are used globally as alternative medicines in the management of a range of disease conditions and are widely accepted across differing societies. Ethiopia hosts a large number of plant species (>7000 higher plant species), of which around 12% are thought to be endemic, making it a rich source of plant extracts potentially useful for human health. The aim of this review is to evaluate Ethiopian medicinal plants for their anti-inflammatory, wound healing, antifungal or antibacterial activities.Methods and analysisThe guidance of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) statement will be used. This review will consider all controlled studies of anti-inflammatory and wound healing properties (both in vivo and in vitro) and in vitro anti-infective properties of medicinal plants found in Ethiopia. Data sources will be EMBASE, PubMed/Medline, Scopus and Google Scholar. Guidance documents on good in vitro methods and checklists for reporting in vitro studies will be used for quality assessment of in vitro studies. The risk of bias tool for animal intervention studies (the SYRCLE RoB tool) will be used to assess the validity of studies. The main outcomes will be percent inhibition of inflammation, time of epithelisation and tissue tensile strength in wounds and microbial growth inhibition.Ethics and disseminationThe findings of this systematic review will be disseminated by publishing in a peer-reviewed journal and via conference presentations. Ethical clearance was obtained from the Brighton and Sussex Medical School, Research Governance & Ethics Committee (RGEC) and Addis Ababa University, College of Health Science, Institutional Review Board.PROSPERO registration numberThis systematic literature review has been registered with PROSPERO (registration number CRD42019127471).

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