The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension

2017 ◽  
Vol 34 ◽  
pp. 266-276 ◽  
Author(s):  
Jelica Grujic-Milanovic ◽  
Zoran Miloradovic ◽  
Djurdjica Jovovic ◽  
Vesna Jacevic ◽  
Ivica Milosavljevic ◽  
...  
Author(s):  
Matthieu Chalopin ◽  
Raffaella Soleti ◽  
Tarek Benameur ◽  
Angela Tesse ◽  
Sebastien Faure ◽  
...  

2008 ◽  
Vol 31 (5) ◽  
pp. 955-962 ◽  
Author(s):  
Chi-Feng Hung ◽  
Yin-Ku Lin ◽  
Zih-Rou Huang ◽  
Jia-You Fang
Keyword(s):  
Red Wine ◽  

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Abdelali Agouni ◽  
Hadj Ahmed Mostefai ◽  
Anne-Hélène Lagrue ◽  
Martina Sladkova ◽  
Philippe Rouet ◽  
...  

The aim of this work was to study the vascular effects of dietary supplementation of a nonalcoholic red wine polyphenol extract, Provinols, in Zucker fatty (ZF) obese rats. ZF or lean rats received diet supplemented or not with Provinols for 8 weeks. Vasoconstriction in response to phenylephrine (Phe) was then assessed in small mesenteric arteries (SMA) and the aorta with emphasis on the contribution of cyclooxygenases (COX). Although no difference in vasoconstriction was observed between ZF and lean rats both in SMA and the aorta, Provinols affected the contribution of COX-derived vasoconstrictor agents. The nonselective COX inhibitor, indomethacin, reduced vasoconstriction in vessels from both groups; however, lower efficacy was observed in Provinols-treated rats. This was associated with a reduction in thromboxane-A2 and 8-isoprostane release. The selective COX-2 inhibitor, NS398, reduced to the same extent vasoconstriction in aortas from ZF and Provinols-treated ZF rats. However, NS398 reduced response to Phe only in SMA from ZF rats. This was associated with a reduction in 8-isoprostane and prostaglandin-E release. Paradoxically, Provinols decreased COX-2 expression in the aorta, while it increased its expression in SMA. We provide here evidence of a subtle and paradoxical regulation of COX pathway by Provinols vessels from obese rats to maintain vascular tone within a physiological range.


2005 ◽  
Vol 519 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
Reginald Liew ◽  
Mark A. Stagg ◽  
Kenneth T. MacLeod ◽  
Peter Collins

2016 ◽  
Vol 56 (4) ◽  
pp. 1467-1475 ◽  
Author(s):  
Nathalie Auberval ◽  
Stéphanie Dal ◽  
Elisa Maillard ◽  
William Bietiger ◽  
Claude Peronet ◽  
...  

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