Sustained release applications of a fluoroalkyl ester-functionalized amphiphilic cyclodextrin by inclusion complex formation with water-soluble drugs in supercritical carbon dioxide

The integrated use of supercritical carbon dioxide (scCO 2 ) and micro- and nanotechnologies has enabled new sustainable strategies for the manufacturing of new medications. ‘Green’ scCO 2 -based methodologies are well suited to improve either the synthesis or materials processing leading to the assembly of three-dimensional multifunctional constructs. By using scCO 2 either as C1 feedstock or as solvent, simple, economic, efficient and clean routes can be designed to synthesize materials with unique properties such as polyurea dendrimers and oxazoline-based polymers/oligomers. These new biocompatible, biodegradable and water-soluble polymeric materials can be engineered into multifunctional constructs with antimicrobial activity, targeting moieties, labelling units and/or efficiently loaded with therapeutics. This mini-review highlights the particular features exhibited by these materials resulting directly from the followed supercritical routes.

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Fabrication of the Components for a Sustained-Release Injectable Dosage Form of Acetylsalicylic Acid Using Supercritical Carbon Dioxide

Russian Journal of Physical Chemistry B ◽

10.1134/s1990793117070028 ◽

2017 ◽

Vol 11 (7) ◽

pp. 1056-1060 ◽

Cited By ~ 1

Author(s):

E. N. Antonov ◽

S. E. Bogorodskii ◽

L. I. Krotova ◽

V. K. Popov ◽

V. Yu. Belov ◽

...

Keyword(s):

Carbon Dioxide ◽

Supercritical Carbon Dioxide ◽

Sustained Release ◽

Acetylsalicylic Acid ◽

Dosage Form ◽

Injectable Dosage ◽

Supercritical Carbon

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Alkalinizing Water-Soluble Local Anesthetic Solutions by Addition of Cyclodextrin

Regional Anesthesia and Pain Medicine ◽

10.1136/rapm-00115550-199823020-00011 ◽

1998 ◽

Vol 23 (2) ◽

pp. 176-181 ◽

Cited By ~ 1

Author(s):

Michio Miyoshi ◽

Toshiaki Imoto ◽

Yasutake Hiji

Keyword(s):

Complex Formation ◽

Inclusion Complex ◽

Local Anesthetic ◽

Local Anesthetics ◽

Water Soluble ◽

Spectral Change ◽

Practical Application ◽

Inclusion Complex Formation ◽

Physiologic Saline ◽

Form Inclusion Complex

Background and objectivesThe use of sodium bicarbonate for alkalinization of local anesthetics to improve their efficacy has some disadvantages including decreased stability of the solutions. The present study was performed to evaluate usefulness of cyclodextrins (CDs) in improving the solubility and stability of local anesthetic solutions at near physiologic pH without precipitation.MethodsSolubility of local anesthetics with or without CDs in physiologic saline was investigated by monitoring cloudiness or precipitate formation visually and by recording absorbance at 620 nm. Interaction of anesthetic and CD was also studied spectrophotometrically using spectral change of the drugs associated with the inclusion complex formation.ResultsCyclodextrins improved the solubility and stability of the four local anesthetics studied (dibucaine, tetracaine, bupivacaine, and lidocaine). In the neutral pH region, the effects of the CDs were more significant with dibucaine and tetracaine, which are more hydrophobic than the other two. A type of effective CD was different for each anesthetic depending partly on the tendency to form inclusion complex with local anesthetic. The local anesthetic solutions solubilized by CDs were found to remain clear for more than 72 hours without any visible precipitation or turbidity at neutral pHs.ConclusionsThe improved solubility of local anesthetics by adding CD may be caused by inclusion complex formation of CD with local anesthetics. This new preparation for the alkalinized water-soluble anesthetic solutions may be useful for practical application in the clinical setting, although this awaits further study.

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