Molecular epidemiology and genetic characterisation of carbapenem-resistant Acinetobacter baumannii isolates from Guangdong Province, South China

2019 ◽  
Vol 17 ◽  
pp. 84-89 ◽  
Author(s):  
Lili Jiang ◽  
Youcai Liang ◽  
Wei Yao ◽  
Juntao Ai ◽  
Xin Wang ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Acinetobacter Baumannii ◽  
South China ◽  
Guangdong Province ◽  
Genetic Characterisation ◽  
Carbapenem Resistant

scholarly journals Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in New Caledonia

2008 ◽  
Vol 14 (10) ◽  
pp. 977-981 ◽  
Author(s):  
S. Le Hello ◽  
V Falcot ◽  
F Lacassin ◽  
F Baumann ◽  
P Nordmann ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Acinetobacter Baumannii ◽  
New Caledonia ◽  
Carbapenem Resistant

scholarly journals Diversity of sequence types and impact of fitness cost among carbapenem-resistant Acinetobacter baumannii isolates from Tripoli, Libya

2021 ◽  
Author(s):  
Antoine G. Abou Fayad ◽  
Louis-Patrick Haraoui ◽  
Ahmad Sleiman ◽  
Mohamad Jaafar ◽  
Abdulaziz Zorgani ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Acinetobacter Baumannii ◽  
Doubling Time ◽  
Core Genome ◽  
Carbapenem Resistance ◽  
Relative Fitness ◽  
Fitness Advantage ◽  
Carbapenem Resistant ◽  
Sequence Types ◽  
Hospital Transmission

We investigated the molecular epidemiology of 21 carbapenem-resistant A. baumannii from Libya, and assessed their relative fitness. Core-genome MLST revealed five inter-hospital transmission clusters. Three clusters were associated with the international clones (IC) IC1, IC2, and IC7. Carbapenem-resistance was associated with bla OXA-23, bla GES-11 , or bla NDM-1 . Compared to A. baumannii DSM 30008, the doubling time was similar over 10 hours, but after 16 hours, half the isolates grew to higher densities, suggesting a fitness advantage.

scholarly journals Molecular Epidemiology and Characterization of Genotypes of Acinetobacter baumannii Isolates from Regions of South China

2016 ◽  
Vol 69 (3) ◽  
pp. 180-185 ◽  
Author(s):  
Jun Ying ◽  
Junwan Lu ◽  
Li Zong ◽  
Ailing Li ◽  
Ruowang Pan ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Acinetobacter Baumannii ◽  
South China

scholarly journals Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in South America

2016 ◽  
Vol 65 (10) ◽  
pp. 1088-1091 ◽  
Author(s):  
Carlos Hernán Rodríguez ◽  
Norah Balderrama Yarhui ◽  
Marcela Nastro ◽  
Tamara Nuñez Quezada ◽  
Glenda Castro Cañarte ◽  
...  
Keyword(s):  
South America ◽  
Molecular Epidemiology ◽  
Acinetobacter Baumannii ◽  
Carbapenem Resistant

scholarly journals Molecular Epidemiology of Emerging bla OXA-23-Like - and bla OXA-24-Like -Carrying Acinetobacter baumannii in Taiwan

2018 ◽  
Vol 62 (3) ◽  
Author(s):  
Shu-Chen Kuo ◽  
Wei-Cheng Huang ◽  
Tzu-Wen Huang ◽  
Hui-Ying Wang ◽  
Jui-Fen Lai ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Acinetobacter Baumannii ◽  
Resistance Genes ◽  
Aminoglycoside Resistance ◽  
S1 Nuclease ◽  
Content Type ◽  
Class A ◽  
Carbapenem Resistant ◽  
Aminoglycoside Resistance Genes ◽  
Resistance Island

ABSTRACT The rate of recovery of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates has increased significantly in recent decades in Taiwan. This study investigated the molecular epidemiology of CRAB with a focus on the mechanisms of resistance and spread in isolates with bla OXA-23-like or bla OXA-24-like . All 555 CRAB isolates in our multicenter collection, which were recovered from 2002 to 2010, were tested for the presence of class A, B, and D carbapenemase genes. All isolates with bla OXA-23-like or bla OXA-24-like were subjected to pulsed-field gel electrophoresis, and 82 isolates (60 isolates with bla OXA-23-like and 22 isolates with bla OXA-24-like ) were selected for multilocus sequence typing to determine the sequence type (ST) and clonal group (CG) and for detection of additional β-lactamase and aminoglycoside resistance genes. The flanking regions of carbapenem and aminoglycoside resistance genes were identified by PCR mapping and sequencing. The localization of bla OXA was determined by S1 nuclease and I-CeuI assays. The numbers of CRAB isolates carrying bla OXA-23-like or bla OXA-24-like , especially those carrying bla OXA-23-like , increased significantly from 2008 onward. The bla OXA-23-like gene was carried by antibiotic resistance genomic island 1 (AbGRI1)-type structures located on plasmids and/or the chromosome in isolates of different STs (CG92 and novel CG786), whereas bla OXA-24-like was carried on plasmids in CRAB isolates of limited STs (CG92). No class A or B carbapenemase genes were identified. Multiple aminoglycoside resistance genes coexisted in CRAB. Tn 6180 -borne armA was found in 74 (90.2%) CRAB isolates, and 58 (70.7%) isolates had Tn 6179 upstream, constituting AbGRI3. bla TEM was present in 38 (46.3%) of the CRAB isolates tested, with 35 (92.1%) isolates containing bla TEM in AbGRI2-type structures, and 61% of ampC genes had IS Aba1 upstream. We conclude that the dissemination and spread of a few dominant lineages of CRAB containing various resistance island structures occurred in Taiwan.

Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates from a Korean hospital that carry blaOXA-23

2018 ◽  
Vol 58 ◽  
pp. 232-236 ◽  
Author(s):  
Hyejin Jeon ◽  
Shukho Kim ◽  
Mi Hyun Kim ◽  
Se Yeon Kim ◽  
Donghyuk Nam ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Acinetobacter Baumannii ◽  
Carbapenem Resistant
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