scholarly journals Enzymatic bioconversion of ginseng powder increases the content of minor ginsenosides and potentiates immunostimulatory activity

2021 ◽  
Author(s):  
Jisang Park ◽  
Ju Kim ◽  
Eun-Sil Ko ◽  
Jong Hoon Jeong ◽  
Cheol-Oh Park ◽  
...  
Keyword(s):  
Immunostimulatory Activity ◽  
Enzymatic Bioconversion

A novel sesquiterpene acid and an alkaloid from leaves of the Eastern Nigerian mistletoe with potent immunostimulatory activity on C57BL6 splenocytes

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
EO Omeje ◽  
PO Osadebe ◽  
A Kawamura ◽  
CO Esimone ◽  
P Proksch ◽  
...  
Keyword(s):  
Immunostimulatory Activity

Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin–Strongylocentyotus internedius

2021 ◽  
Vol 258 ◽  
pp. 117701
Author(s):  
Qing-Chi Wang ◽  
Maosheng Wei ◽  
Yang Yue ◽  
Ning Wu ◽  
Jing Wang ◽  
...  
Keyword(s):  
Sea Urchin ◽  
Structural Characterization ◽  
Immunostimulatory Activity

scholarly journals Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation

2009 ◽  
Vol 206 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Kerstin Werninghaus ◽  
Anna Babiak ◽  
Olaf Groß ◽  
Christoph Hölscher ◽  
Harald Dietrich ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Subunit Vaccine ◽  
Vaccine Development ◽  
Adaptor Protein ◽  
Synthetic Analogue ◽  
Dependent Manner ◽  
Immunostimulatory Activity ◽  
Adjuvant Activity ◽  
Cord Factor

Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently needed. The use of recombinant MTB antigens as subunit vaccines is a promising approach, but requires adjuvants that activate antigen-presenting cells (APCs) for elicitation of protective immunity. The mycobacterial cord factor Trehalose-6,6-dimycolate (TDM) and its synthetic analogue Trehalose-6,6-dibehenate (TDB) are effective adjuvants in combination with MTB subunit vaccine candidates in mice. However, it is unknown which signaling pathways they engage in APCs and how these pathways are coupled to the adaptive immune response. Here, we demonstrate that these glycolipids activate macrophages and dendritic cells (DCs) via Syk–Card9–Bcl10–Malt1 signaling to induce a specific innate activation program distinct from the response to Toll-like receptor (TLR) ligands. APC activation by TDB and TDM was independent of the C-type lectin receptor Dectin-1, but required the immunoreceptor tyrosine-based activation motif–bearing adaptor protein Fc receptor γ chain (FcRγ). In vivo, TDB and TDM adjuvant activity induced robust combined T helper (Th)-1 and Th-17 T cell responses to a MTB subunit vaccine and partial protection against MTB challenge in a Card9-dependent manner. These data provide a molecular basis for the immunostimulatory activity of TDB and TDM and identify the Syk–Card9 pathway as a rational target for vaccine development against tuberculosis.

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