Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells

2011 ◽  
Vol 55 (2) ◽  
pp. 351-358 ◽  
Author(s):  
Laia Caja ◽  
Patricia Sancho ◽  
Esther Bertran ◽  
Isabel Fabregat
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Epidermal Growth ◽  
Induced Apoptosis ◽  
Human Hepatocellular Carcinoma Cells

Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells

2012 ◽  
Vol 57 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Marie-José Blivet-Van Eggelpoël ◽  
Hamza Chettouh ◽  
Laetitia Fartoux ◽  
Lynda Aoudjehane ◽  
Véronique Barbu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Response ◽  
Growth Factor Receptor ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Epidermal Growth

scholarly journals Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression–induced apoptosis in hepatoma cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769502 ◽  
Author(s):  
Kai Liu ◽  
Dongdong Lin ◽  
Yabo Ouyang ◽  
Lijun Pang ◽  
Xianghua Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepg2 Cells ◽  
Apoptotic Cell ◽  
Growth Factor Receptor ◽  
Hepatoma Cells ◽  
Epidermal Growth ◽  
Induced Apoptosis

Overexpression of apoptosis-stimulating protein 2 of p53 (ASPP2) induces apoptotic cell death in hepatoma cells (e.g. HepG2 cells) by enhancing the transactivation activity of p53, but long-term ASPP2 overexpression fails to induce more apoptosis since activation of the epidermal growth factor/epidermal growth factor receptor/SOS1 pathway impairs the pro-apoptotic role of ASPP2. In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin expression in a p53-dependent manner. Although amphiregulin initially contributes to ASPP2-induced apoptosis, it eventually impairs the pro-apoptotic function of ASPP2 by activating the epidermal growth factor/epidermal growth factor receptor/SOS1 pathway, leading to apoptosis resistance. Moreover, blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis. Thus, our data elucidate an apoptosis-evasion mechanism in hepatocellular carcinoma and have potential implications for hepatocellular carcinoma therapy.

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