scholarly journals It’s not all in the cilium, but on the road to it: Genetic interaction network in polycystic kidney and liver diseases and how trafficking and quality control matter

2012 ◽  
Vol 56 (5) ◽  
pp. 1201-1203 ◽  
Author(s):  
Carsten Bergmann ◽  
Ralf Weiskirchen
Keyword(s):  
Quality Control ◽  
Liver Diseases ◽  
Genetic Interaction ◽  
Interaction Network ◽  
Polycystic Kidney ◽  
The Road ◽  
Genetic Interaction Network ◽  
On The Road

scholarly journals A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

2011 ◽  
Vol 43 (7) ◽  
pp. 639-647 ◽  
Author(s):  
Sorin V Fedeles ◽  
Xin Tian ◽  
Anna-Rachel Gallagher ◽  
Michihiro Mitobe ◽  
Saori Nishio ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Genetic Interaction ◽  
Interaction Network ◽  
Cyst Formation ◽  
Polycystic Kidney ◽  
Genetic Interaction Network

scholarly journals Construction and application of a protein and genetic interaction network (yeast interactome)

2009 ◽  
Vol 37 (7) ◽  
pp. e54-e54 ◽  
Author(s):  
Gregory R. Stuart ◽  
William C. Copeland ◽  
Micheline K. Strand
Keyword(s):  
Genetic Interaction ◽  
Interaction Network ◽  
Genetic Interaction Network

scholarly journals Variance in Epistasis Links Gene Regulation and Evolutionary Rate in the Yeast Genetic Interaction Network

2012 ◽  
Vol 4 (11) ◽  
pp. 1080-1087 ◽  
Author(s):  
Janna L. Fierst ◽  
Patrick C. Phillips
Keyword(s):  
Gene Regulation ◽  
Evolutionary Rate ◽  
Genetic Interaction ◽  
Interaction Network ◽  
Genetic Interaction Network ◽  
Yeast Genetic

On the road to nowhere: cross-talk between post-translational protein targeting and cytosolic quality control

2016 ◽  
Vol 44 (3) ◽  
pp. 796-801 ◽  
Author(s):  
Joseph Casson ◽  
Michael McKenna ◽  
Stephen High
Keyword(s):  
Quality Control ◽  
Mammalian Cells ◽  
Protein Targeting ◽  
Decisive Role ◽  
Proteasomal Degradation ◽  
Tetratricopeptide Repeat ◽  
The Road ◽  
Precursor Proteins ◽  
On The Road ◽  
Ta Proteins

A well-defined co-translational pathway couples the synthesis and translocation of nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), thereby minimizing the possibility of the hydrophobic signals and transmembrane domains that such proteins contain from being exposed to the cytosol. Nevertheless, a proportion of these co-translational substrates may fail to reach the ER, and therefore mislocalize to the cytosol where their intrinsic hydrophobicity makes them aggregation-prone. A range of hydrophobic precursor proteins that employ alternative, post-translational, routes for ER translocation also contribute to the cytosolic pool of mislocalized proteins (MLPs). In this review, we detail how mammalian cells can efficiently deal with these MLPs by selectively targeting them for proteasomal degradation. Strikingly, this pathway for MLP degradation is regulated by cytosolic components that also facilitate the TRC40-dependent, post-translational, delivery of tail-anchored membrane proteins (TA proteins) to the ER. Among these components are small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and Bcl-2-associated athanogene 6 (BAG6), which appear to play a decisive role in enforcing quality control over hydrophobic precursor proteins that have mislocalized to the cytosol, directing them to either productive membrane insertion or selective ubiquitination and proteasomal degradation.

scholarly journals Network motif analysis of a multi-mode genetic-interaction network

2007 ◽  
Vol 8 (8) ◽  
pp. R160 ◽  
Author(s):  
R James Taylor ◽  
Andrew F Siegel ◽  
Timothy Galitski
Keyword(s):  
Genetic Interaction ◽  
Network Motif ◽  
Interaction Network ◽  
Motif Analysis ◽  
Genetic Interaction Network ◽  
Multi Mode

Genetic Interaction Network

2004 ◽  
Vol 2004 (219) ◽  
pp. tw55-tw55
Keyword(s):  
Genetic Interaction ◽  
Interaction Network ◽  
Genetic Interaction Network

scholarly journals mSphere of Influence: Comprehensive Genetic Analysis

mSphere ◽  
2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Jason M. Peters
Keyword(s):  
Antibiotic Resistance ◽  
Genetic Analysis ◽  
Gene Networks ◽  
Genetic Interaction ◽  
Interaction Network ◽  
Cellular Function ◽  
Biofuel Production ◽  
Wiring Diagram ◽  
Genetic Interaction Network ◽  
New Biology

ABSTRACT Jason M. Peters works in the fields of antibiotic resistance and biofuel production. In this mSphere of Influence article, he reflects on how the paper “A global genetic interaction network maps a wiring diagram of cellular function” by Costanzo et al. (Science 353:aaf1420, 2016, https://doi.org/10.1126/science.aaf1420) has impacted his work by highlighting the power of gene networks to uncover new biology.

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