scholarly journals Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

2021 ◽  
Author(s):  
Maria Reich ◽  
Lina Spomer ◽  
Caroline Klindt ◽  
Katharina Fuchs ◽  
Jan Stindt ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Sclerosing Cholangitis ◽  
Biliary Epithelial Cells

TLR4, TLR9, and NLRP3 in biliary epithelial cells of primary sclerosing cholangitis: Relationship with clinical characteristics

2015 ◽  
Vol 30 (3) ◽  
pp. 600-608 ◽  
Author(s):  
Hiroshi Matsushita ◽  
Yasuhiro Miyake ◽  
Akinobu Takaki ◽  
Tetsuya Yasunaka ◽  
Kazuko Koike ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Clinical Characteristics ◽  
Biliary Epithelial Cells

scholarly journals A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias

2004 ◽  
Vol 11 (3-4) ◽  
pp. 205-213 ◽  
Author(s):  
Chih-Te Wu ◽  
Paul A. Davis ◽  
VelImir A. Luketic ◽  
M. Eric Gershwin
Keyword(s):  
Epithelial Cells ◽  
Primary Biliary Cirrhosis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Tissue Injury ◽  
Cell Interaction ◽  
Biliary Cirrhosis ◽  
Drug Induced ◽  
Biliary Epithelial Cells ◽  
Immunological Diseases

Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.

Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis

2002 ◽  
Vol 22 (3) ◽  
pp. 228-234 ◽  
Author(s):  
Jill Tinmouth ◽  
Mary Lee ◽  
Ian R. Wanless ◽  
Florence W. L. Tsui ◽  
Robert Inman ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Primary Biliary Cirrhosis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Cirrhosis ◽  
Biliary Epithelial Cells

Ultrastructural Changes Associated with Alcoholic Hyalin in Hepatocytes and Biliary Epithelial Cells

1971 ◽  
Vol 29 ◽  
pp. 572-573
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Endoplasmic Reticulum ◽  
Epithelial Cells ◽  
Liver Biopsy ◽  
Alcoholic Hepatitis ◽  
Ultrastructural Changes ◽  
Main Mass ◽  
Biliary Epithelial Cells ◽  
Biopsy Specimens ◽  
Alcoholic Hyalin

To learn more of the nature and origin of alcoholic hyalin (AH), 15 liver biopsy specimens from patients with alcoholic hepatitis were studied in detail.AH was found not only in hepatocytes but also in ductular cells (Figs. 1 and 2), although in the latter location only rarely. The bulk of AH consisted of a randomly oriented network of closely packed filaments measuring about 150 Å in width. Bundles of filaments smaller in diameter (40-90 Å) were observed along the periphery of the main mass (Fig. 1), often surrounding it in a rim-like fashion. Fine filaments were also found close to the nucleus in both hepatocytes and biliary epithelial cells, the latter even though characteristic AH was not present (Figs. 3 and 4). Dispersed among the larger filaments were glycogen, RNA particles and profiles of endoplasmic reticulum. Dilated cisternae of endoplasmic reticulum were often conspicuous around the periphery of the AH mass. A limiting membrane was not observed.

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