scholarly journals 025 ALA-PDT inhibits skin squamous cell carcinoma (cSCC) via regulating formation of tertiary lymphoid structures

2021 ◽  
Vol 141 (5) ◽  
pp. S5
Author(s):  
Q. Zeng ◽  
G. Zhang ◽  
G. Yan ◽  
P. Wang ◽  
X. Wang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Skin Squamous Cell Carcinoma ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

High infiltration of B cells in tertiary lymphoid structures, TCR oligoclonality, and neoantigens are part of esophageal squamous cell carcinoma microenvironment

2020 ◽  
Vol 108 (4) ◽  
pp. 1307-1318
Author(s):  
Luciana Rodrigues Carvalho Barros ◽  
Paulo Thiago De Souza‐Santos ◽  
Marco Antonio Marques Pretti ◽  
Gustavo Fioravanti Vieira ◽  
Marcelo Alves De Souza Bragatte ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures ◽  
High Infiltration

scholarly journals B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ayana T. Ruffin ◽  
Anthony R. Cillo ◽  
Tracy Tabib ◽  
Angen Liu ◽  
Sayali Onkar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Spatial Organization ◽  
Neck Squamous Cell Carcinoma ◽  
Transitional State ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

AbstractCurrent immunotherapy paradigms aim to reinvigorate CD8+ T cells, but the contribution of humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in head and neck squamous cell carcinoma (HNSCC) caused by human papillomavirus infection (HPV+), patients have transcriptional signatures of germinal center (GC) tumor infiltrating B cells (TIL-Bs) and spatial organization of immune cells consistent with tertiary lymphoid structures (TLS) with GCs, both of which correlate with favorable outcome. GC TIL-Bs in HPV+ HNSCC are characterized by distinct waves of gene expression consistent with dark zone, light zone and a transitional state of GC B cells. Semaphorin 4a expression is enhanced on GC TIL-Bs present in TLS of HPV+ HNSCC and during the differentiation of TIL-Bs. Our study suggests that therapeutics to enhance TIL-B responses in HNSCC should be prioritized in future studies to determine if they can complement current T cell mediated immunotherapies.

scholarly journals Erratum: Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

2016 ◽  
Vol 22 (2) ◽  
pp. 217-217 ◽  
Author(s):  
Dany Nassar ◽  
Mathilde Latil ◽  
Bram Boeckx ◽  
Diether Lambrechts ◽  
Cédric Blanpain
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mouse Skin ◽  
Skin Squamous Cell Carcinoma ◽  
Genomic Landscape
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