scholarly journals B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ayana T. Ruffin ◽  
Anthony R. Cillo ◽  
Tracy Tabib ◽  
Angen Liu ◽  
Sayali Onkar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Spatial Organization ◽  
Neck Squamous Cell Carcinoma ◽  
Transitional State ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

AbstractCurrent immunotherapy paradigms aim to reinvigorate CD8+ T cells, but the contribution of humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in head and neck squamous cell carcinoma (HNSCC) caused by human papillomavirus infection (HPV+), patients have transcriptional signatures of germinal center (GC) tumor infiltrating B cells (TIL-Bs) and spatial organization of immune cells consistent with tertiary lymphoid structures (TLS) with GCs, both of which correlate with favorable outcome. GC TIL-Bs in HPV+ HNSCC are characterized by distinct waves of gene expression consistent with dark zone, light zone and a transitional state of GC B cells. Semaphorin 4a expression is enhanced on GC TIL-Bs present in TLS of HPV+ HNSCC and during the differentiation of TIL-Bs. Our study suggests that therapeutics to enhance TIL-B responses in HNSCC should be prioritized in future studies to determine if they can complement current T cell mediated immunotherapies.

High infiltration of B cells in tertiary lymphoid structures, TCR oligoclonality, and neoantigens are part of esophageal squamous cell carcinoma microenvironment

2020 ◽  
Vol 108 (4) ◽  
pp. 1307-1318
Author(s):  
Luciana Rodrigues Carvalho Barros ◽  
Paulo Thiago De Souza‐Santos ◽  
Marco Antonio Marques Pretti ◽  
Gustavo Fioravanti Vieira ◽  
Marcelo Alves De Souza Bragatte ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures ◽  
High Infiltration

scholarly journals Single-Cell Spatial Proteomics Analyses of Head and Neck Squamous Cell Carcinoma Reveal Tumor Heterogeneity and Immune Architectures Associated with Clinical Outcome

2021 ◽  
Author(s):  
Katie E. Blise ◽  
Shamilene Sivagnanam ◽  
Grace L. Banik ◽  
Lisa M. Coussens ◽  
Jeremy Goecks
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Single Cell ◽  
Squamous Cell ◽  
Immune Cells ◽  
Spatial Organization ◽  
Patient Survival ◽  
Response To Therapy ◽  
Neck Squamous Cell Carcinoma

ABSTRACTRecent research has provided compelling evidence that the spatial organization of cells within the tumor-immune microenvironment (TiME) of solid tumors correlates with survival and response to therapy in numerous cancer types. Here, we report results of a quantitative single-cell spatial analysis of the TiME of primary and recurrent human head and neck squamous cell carcinoma (HNSCC) tumors, that builds upon our initial longitudinal study of these same HNSCCs that annotated immune complexity at near single cell resolution. Herein, we extended multiple spatial algorithms to quantify spatial landscapes of immune cells within TiMEs. Most notably, we report that spatial compartmentalization, rather than mixing, between neoplastic tumor cells and immune cells is associated with longer patient survival, as well as revealing mesenchymal spatial cellular neighborhoods and their association with improved patient outcomes. Results reported herein are concordant with studies in other tumor types, thus indicating that cellular heterogeneity within tumors trends with spatial TiME features, and are likely prognostic for patient survival.

P8 Tumor-associated B cells in head and neck squamous cell carcinoma (HNSCC)

Oral Oncology ◽  
2015 ◽  
Vol 51 (5) ◽  
pp. e45
Author(s):  
A. Lechner ◽  
H. Schlößer ◽  
M. Thelen ◽  
A. Shimabukuro-Vornhagen ◽  
D. Beutner ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

scholarly journals Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma

2019 ◽  
Vol 8 (3) ◽  
pp. 1535293 ◽  
Author(s):  
Axel Lechner ◽  
Hans A. Schlößer ◽  
Martin Thelen ◽  
Kerstin Wennhold ◽  
Sacha I. Rothschild ◽  
...  
Keyword(s):  
Immune Response ◽  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Humoral Immune Response ◽  
Neck Squamous Cell Carcinoma ◽  
Humoral Immune

scholarly journals Associated with Immune Function, miR-150-5p is a Favorable Biomarker for Head and Neck Cancer Patients

2021 ◽  
Author(s):  
Zhi-Jie Liu ◽  
Li-Sheng Li-Sheng ◽  
Jing Wang ◽  
Li-Xia Peng ◽  
Yan Mei ◽  
...  
Keyword(s):  
Immune Response ◽  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Cross Talk ◽  
Neck Squamous Cell Carcinoma

Abstract BackgroundAccumulating evidence has shown that dysregulated expression of microRNAs plays a key role in tumorigenesis. To explore the mechanisms of this we conducted this study.MethodsFive Gene Expression Omnibus datasets (GEO) datasets , GSE32960, GSE36682, GSE43039, GSE70970 and GSE118613 and head and neck squamous cell carcinoma data of The Cancer Genome Atlas (TCGA) were analysis in this study.ResultsBy analyzing the microRNA expression profile of nasopharyngeal carcinoma (NPC) in the five GEO datasets, we identified miR-150-5p as potential biomarker for patient survival. To explore the mechanisms of this, We examined the head and neck squamous cell carcinoma data of TCGA and found that miR-150-5p was correlated with high enrichment of tumor-infiltrating B cells, low enrichment of cancer-associated fibroblasts and down-regulated oncogenic pathways. miR-150-5p may also improve the immune response in the tumor microenvironment. These findings may explain how miR-150-5p improves outcome of head and neck squamous cell carcinoma patients including NPC. Additionally, the exosomal long non-coding RNA AC073130.1 was identified as a potential regulator of miR-150-5p. As miR-150-5p can also be released via exosomes, this study provides insight into the cross-talk of tumor cells and B cells in the tumor microenvironment via exosomal AC073130.1 and miR-150-5p. ConclusionMiR-150-5p improves outcome of head and neck squamous cell carcinoma patients by improving the immune response. There might be a cross-talk of tumor cells and B cells in the tumor microenvironment via exosomal AC073130.1 and miR-150-5p.

scholarly journals The influence of chemotherapy on adenosine-producing B cells in patients with head and neck squamous cell carcinoma

Oncotarget ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 5834-5847 ◽  
Author(s):  
Andreas Ziebart ◽  
Ulrich Huber ◽  
Sandra Jeske ◽  
Simon Laban ◽  
Johannes Doescher ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma
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