Vanadium complexes with polypyridyl ligands: Speciation, structure and potential medicinal activity

Electrochemical oxidation of [V(IV)O(nta)(H2O)]- (H3nta nitrilotriacetic acid) was studied in aqueous solution by means of cyclic voltammetry, differential pulse polarography, and current sampled DC polarography on mercury as electrode material. In the pH-range under study (5.5-9.0) the corresponding V(V) complex is produced by one-electron oxidation of the parent V(IV) species. The oxidation product is stable within the time scale of cyclic voltammetry. The evaluation of the pH-dependence of the half-wave potentials leads to a pKa value for [V(IV)O(nta)(H2O)]- which is in a good agreement with previous determinations. The measured value for E1/2 is very close to the formal potential E0 calculated via the Nernst equation on the basis of known literature values for log Kox and log Kred, the complex stability constants for the oxidized and reduced form, respectively.

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Electroanalytical chemistry of vanadium complexes. Comparison of the voltammetric features of amavadine with those of the vanadium complexes with iminodiacetic acid and methyliminodiacetic acid

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19890053 ◽

1989 ◽

Vol 54 (1) ◽

pp. 53-63 ◽

Cited By ~ 4

Author(s):

Roland Meier ◽

Harald Frank ◽

Reinhard Kirmse ◽

Reiner Salzer ◽

Joachim Stach ◽

...

Keyword(s):

Iminodiacetic Acid ◽

Vanadium Complexes ◽

Reduction Mechanism ◽

Reversible Process ◽

Electroanalytical Chemistry ◽

Probable Explanation ◽

Chemical Sense ◽

Ece Mechanism ◽

Methyliminodiacetic Acid

The voltammetric behaviour of amavadine (AV) was found to be considerably different from that of the complexes of VO2+ with methyliminodiacetic acid (MIDA) and iminodiacetic acid (IDA). To get an insight in the rather complicated reduction mechanism of the latter complexes the reductions of V(III) (MIDA) and V(III) (IDA) have been studied for comparison. The species V(III) (MIDA)2 and V(III) (IDA)2 are reduced to the appropriate V(II) complexes in a chemically reversible process. VO(MIDA)2 and VO(IDA)2 are reduced to the same complexes via an ECE mechanism. The investigation of the electroreduction of AV shows that this process is not reversible in the chemical sense. As a probable explanation, the conclusion was drawn that AV and the usual V(IV)O-iminocarboxylato complexes differ in their structures.

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Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process

Oncotarget ◽

10.18632/oncotarget.19454 ◽

2017 ◽

Vol 8 (36) ◽

pp. 60324-60341 ◽

Cited By ~ 19

Author(s):

Szymon Kowalski ◽

Stanisław Hać ◽

Dariusz Wyrzykowski ◽

Agata Zauszkiewicz-Pawlak ◽

Iwona Inkielewicz-Stępniak

Keyword(s):

Pancreatic Ductal Adenocarcinoma ◽

Cell Line ◽

Mitotic Catastrophe ◽

Ductal Adenocarcinoma ◽

Vanadium Complexes ◽

Adenocarcinoma Cell Line ◽

Selective Cytotoxicity ◽

Adenocarcinoma Cell

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Novel chalcogenide vanadium complexes with β-diimine ligand: synthesis and structural studies

Journal of Coordination Chemistry ◽

10.1080/00958972.2019.1613649 ◽

2019 ◽

Vol 72 (10) ◽

pp. 1661-1670 ◽

Cited By ~ 3

Author(s):

A. Yu. Konokhova ◽

M. Yu. Afonin ◽

T. S. Sukhikh ◽

S. N. Konchenko

Keyword(s):

Vanadium Complexes ◽

Structural Studies ◽

Diimine Ligand ◽

Ligand Synthesis

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Reactivity studies of η6-arene ruthenium (II) dimers with polypyridyl ligands: isolation of mono, binuclear p-cymene ruthenium (II) complexes and bisterpyridine ruthenium (II) complexes

Polyhedron ◽

10.1016/s0277-5387(03)00460-1 ◽

2003 ◽

Vol 22 (23) ◽

pp. 3155-3160 ◽

Cited By ~ 44

Author(s):

R. Lalrempuia ◽

Mohan Rao Kollipara

Keyword(s):

Polypyridyl Ligands

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Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma

Bioinorganic Chemistry and Applications ◽

10.1155/2011/206316 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 12

Author(s):

R. Francik ◽

M. Krośniak ◽

M. Barlik ◽

A. Kudła ◽

R. Gryboś ◽

...

Keyword(s):

Wistar Rats ◽

Reduced Glutathione ◽

The Body ◽

Stress Factors ◽

Control Group ◽

Vanadium Complexes ◽

Healthy Male ◽

Reducing Ability ◽

Male Wistar Rats ◽

Antioxidant Parameters

The aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP—ferric reducing ability of plasma, and reduced glutathione—GSH) and enzymatic (glutathione peroxidase—GPx, catalase—CAT, and GPx/CAT ratio) activity in the plasma of healthy male Wistar rats. Three vanadium complexes: [VO(bpy)2]SO4⋅2H2O, [VO(4,4′Me2bpy)2]SO4⋅2H2O, and Na[VO(O2)2(bpy)]⋅8H2O are administered by gavage during 5 weeks in two different diets such as control (C) and high fatty (F) diets. Changes of biochemical and antioxidants parameters are measured in plasma. All three vanadium complexes statistically decrease the body mass growth in comparison to the control and fatty diet. In plasma GSH was statistically increased in all vanadium complexes-treated rats from control and fatty group in comparison to only control group. Calculated GPX/CAT ratio was the highest in the control group in comparison to others.

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