scholarly journals Pseudo-atoms, atoms and a Jordan type decomposition in effect algebras

2008 ◽  
Vol 344 (1) ◽  
pp. 238-252 ◽  
Author(s):  
Mona Khare ◽  
Akhilesh Kumar Singh
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hanyu Zhang ◽  
Ruoyi Cai ◽  
James Dai ◽  
Wei Sun

AbstractWe introduce a new computational method named EMeth to estimate cell type proportions using DNA methylation data. EMeth is a reference-based method that requires cell type-specific DNA methylation data from relevant cell types. EMeth improves on the existing reference-based methods by detecting the CpGs whose DNA methylation are inconsistent with the deconvolution model and reducing their contributions to cell type decomposition. Another novel feature of EMeth is that it allows a cell type with known proportions but unknown reference and estimates its methylation. This is motivated by the case of studying methylation in tumor cells while bulk tumor samples include tumor cells as well as other cell types such as infiltrating immune cells, and tumor cell proportion can be estimated by copy number data. We demonstrate that EMeth delivers more accurate estimates of cell type proportions than several other methods using simulated data and in silico mixtures. Applications in cancer studies show that the proportions of T regulatory cells estimated by DNA methylation have expected associations with mutation load and survival time, while the estimates from gene expression miss such associations.


Order ◽  
2020 ◽  
Author(s):  
Anna Jenčová ◽  
Sylvia Pulmannová

2010 ◽  
Vol 50 (4) ◽  
pp. 1160-1166
Author(s):  
Qingshui Lin ◽  
Ronglu Li
Keyword(s):  

2010 ◽  
Vol 60 (6) ◽  
Author(s):  
Jiří Rachůnek ◽  
Dana Šalounová

AbstractBounded Rℓ-monoids form a large subclass of the class of residuated lattices which contains certain of algebras of fuzzy and intuitionistic logics, such as GMV-algebras (= pseudo-MV-algebras), pseudo-BL-algebras and Heyting algebras. Moreover, GMV-algebras and pseudo-BL-algebras can be recognized as special kinds of pseudo-MV-effect algebras and pseudo-weak MV-effect algebras, i.e., as algebras of some quantum logics. In the paper, bipartite, local and perfect Rℓ-monoids are investigated and it is shown that every good perfect Rℓ-monoid has a state (= an analogue of probability measure).


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