Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis

2021 ◽  
Vol 433 (1) ◽  
pp. 166655 ◽  
Author(s):  
Angela A. Wang ◽  
Jennifer L. Gommerman ◽  
Olga L. Rojas
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Cytokine Production ◽  
Plasma Cells ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Autoreactive CD19+CD20−Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis

2016 ◽  
Vol 196 (4) ◽  
pp. 1541-1549 ◽  
Author(s):  
Ding Chen ◽  
Sara J. Ireland ◽  
Laurie S. Davis ◽  
Xiangmei Kong ◽  
Ann M. Stowe ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Disease Severity ◽  
Plasma Cells ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production

2008 ◽  
Vol 8 (9) ◽  
pp. 1282-1290 ◽  
Author(s):  
Irena Lavrnja ◽  
Danijela Stojkov ◽  
Ivana Bjelobaba ◽  
Sanja Pekovic ◽  
Sanja Dacic ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Cytokine Production ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Pregnancy Suppresses Experimental Autoimmune Encephalomyelitis through Immunoregulatory Cytokine Production

2007 ◽  
Vol 179 (12) ◽  
pp. 8146-8152 ◽  
Author(s):  
Melanie A. McClain ◽  
NaTosha N. Gatson ◽  
Nicole D. Powell ◽  
Tracey L. Papenfuss ◽  
Ingrid E. Gienapp ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Cytokine Production ◽  
Autoimmune Encephalomyelitis ◽  
Immunoregulatory Cytokine ◽  
Experimental Autoimmune

scholarly journals T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation

2020 ◽  
Vol 218 (2) ◽  
Author(s):  
Saskia Hemmers ◽  
Michail Schizas ◽  
Alexander Y. Rudensky
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Cytokine Production ◽  
Disease Exacerbation ◽  
Autoimmune Encephalomyelitis ◽  
Γδt Cells ◽  
Visceral Adipose ◽  
Experimental Autoimmune

ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells residing in nonlymphoid tissues, and these cells can potently expand upon provision of exogenous IL-33. Whether the accumulation and residence of T reg cells in tissues requires their cell-intrinsic expression of and signaling by ST2, or whether indirect IL-33 signaling acting on other cells suffices, has been a matter of contention. Here, we report that ST2 expression on T reg cells is largely dispensable for their accumulation and residence in nonlymphoid organs, including the visceral adipose tissue (VAT), even though cell-intrinsic sensing of IL-33 promotes type 2 cytokine production by VAT-residing T reg cells. In addition, we uncovered a novel ST2-dependent role for T reg cells in limiting the size of IL-17A–producing γδT cells in the CNS in a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis (EAE). Finally, ST2 deficiency limited to T reg cells led to disease exacerbation in EAE.

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