Reprogramming Substrate and Catalytic Promiscuity of Tryptophan Prenyltransferases

2021 ◽  
Vol 433 (2) ◽  
pp. 166726
Author(s):  
Elena Ostertag ◽  
Liujuan Zheng ◽  
Karina Broger ◽  
Thilo Stehle ◽  
Shu-Ming Li ◽  
...  
Keyword(s):  
Catalytic Promiscuity

scholarly journals Catalytic promiscuity inPseudomonas aeruginosaarylsulfatase as an example of chemistry-driven protein evolution

FEBS Letters ◽  
2012 ◽  
Vol 586 (11) ◽  
pp. 1622-1630 ◽  
Author(s):  
Jinghui Luo ◽  
Bert van Loo ◽  
Shina C.L. Kamerlin
Keyword(s):  
Protein Evolution ◽  
Catalytic Promiscuity

scholarly journals Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase

2019 ◽  
Vol 17 (5) ◽  
pp. 1206-1214 ◽  
Author(s):  
Marianna Loizzi ◽  
David J. Miller ◽  
Rudolf K. Allemann
Keyword(s):  
High Fidelity ◽  
Catalytic Promiscuity ◽  
Terpene Cyclase

Aza-analogues of carbocations inhibit δ-cadinene synthase: 1,6-cyclisation.

scholarly journals ProtMiscuity: a database of promiscuous proteins

Database ◽  
2019 ◽  
Vol 2019 ◽  
Author(s):  
Ana Julia Velez Rueda ◽  
Nicolas Palopoli ◽  
Matías Zacarías ◽  
Leandro Matías Sommese ◽  
Gustavo Parisi
Keyword(s):  
Structure Function ◽  
Kinetic Parameters ◽  
Active Sites ◽  
Online Database ◽  
Catalytic Promiscuity ◽  
External Resources ◽  
Functional Annotations ◽  
Underlying Mechanisms ◽  
Function Relationship ◽  
Derived Data

Abstract Promiscuous behaviour in proteins and enzymes remains a challenging feature to understand the structure–function relationship. Here we present ProtMiscuity, a manually curated online database of proteins showing catalytic promiscuity. ProtMiscuity contains information about canonical and promiscuous activities comprising 88 different reactions in 57 proteins from 40 different organisms. It can be searched or browsed by protein names, organisms and descriptions of canonical and promiscuous reactions. Entries provide information on reaction substrates, products and kinetic parameters, mapping of active sites to sequence and structure and links to external resources with biological and functional annotations. ProtMiscuity could assist in studying the underlying mechanisms of promiscuous reactions by offering a unique and curated collection of experimentally derived data that is otherwise hard to find, retrieve and validate from literature.

Superior Proton‐Transfer Catalytic Promiscuity of Cytochrome  c in Self‐Organized Media

ChemBioChem ◽  
2020 ◽  
Author(s):  
Sheetal Rani ◽  
Basundhara Dasgupta ◽  
Gaurav Kumar Bhati ◽  
Kalpana Tomar ◽  
Sabyasachi Rakshit ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Proton Transfer ◽  
Catalytic Promiscuity ◽  
Self Organized ◽  
Organized Media

Catalytic promiscuity of the non-native FPP substrate in the TEAS enzyme: non-negligible flexibility of the carbocation intermediate

2018 ◽  
Vol 20 (22) ◽  
pp. 15061-15073 ◽  
Author(s):  
Fan Zhang ◽  
Yong-Heng Wang ◽  
Xiaowen Tang ◽  
Ruibo Wu
Keyword(s):  
Md Simulations ◽  
Conformational Flexibility ◽  
Catalytic Promiscuity

By QM(DFT)/MM MD simulations, it has been revealed that the non-native substrate catalytic promiscuity of TEAS (one of the sesquiterpene cyclases) is mostly attributable to its notable conformational flexibility of the branching intermediate bisabolyl cation.

scholarly journals Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines

ChemBioChem ◽  
2019 ◽  
Vol 20 (6) ◽  
pp. 800-812 ◽  
Author(s):  
Vasilis Tseliou ◽  
Marcelo F. Masman ◽  
Wesley Böhmer ◽  
Tanja Knaus ◽  
Francesco G. Mutti
Keyword(s):  
Asymmetric Synthesis ◽  
Primary Amines ◽  
Catalytic Promiscuity ◽  
Mechanistic Insight ◽  
Insight Into

scholarly journals Diastereoselective synthesis of bis(α-aminophosphonates) by lipase catalytic promiscuity

2019 ◽  
Vol 43 (21) ◽  
pp. 8153-8159 ◽  
Author(s):  
Rim Aissa ◽  
Samia Guezane-Lakoud ◽  
Emilie Kolodziej ◽  
Martial Toffano ◽  
Louisa Aribi-Zouioueche
Keyword(s):  
Candida Antarctica ◽  
Diastereoselective Synthesis ◽  
Catalytic Promiscuity

New bis(α-aminophosphonates) were directly prepared with high diastereoselectivity by lipase catalytic promiscuity in the presence of immobilized Candida antarctica lipase.

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