Nonlinear viscoelastic properties of native male human skin and in vitro 3D reconstructed skin models under LAOS stress

2019 ◽  
Vol 96 ◽  
pp. 310-323 ◽  
Author(s):  
Sharadwata Pan ◽  
Deepika Malhotra ◽  
Natalie Germann
Keyword(s):  
Human Skin ◽  
Viscoelastic Properties ◽  
Reconstructed Skin ◽  
Nonlinear Viscoelastic

Linear viscoelastic and microstructural properties of native male human skin and in vitro 3D reconstructed skin models

2019 ◽  
Vol 90 ◽  
pp. 644-654 ◽  
Author(s):  
Deepika Malhotra ◽  
Sharadwata Pan ◽  
Lars Rüther ◽  
Thomas B. Goudoulas ◽  
Gerrit Schlippe ◽  
...  
Keyword(s):  
Human Skin ◽  
Microstructural Properties ◽  
Reconstructed Skin ◽  
Linear Viscoelastic

A broad-spectrum sunscreen prevents UVA radiation-induced gene expression in reconstructed skin in vitro and in human skin in vivo

2011 ◽  
Vol 20 (6) ◽  
pp. 477-482 ◽  
Author(s):  
Claire Marionnet ◽  
Susanne Grether-Beck ◽  
Sophie Seité ◽  
Alessandra Marini ◽  
Thomas Jaenicke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Skin ◽  
Broad Spectrum ◽  
Reconstructed Skin ◽  
Radiation Induced ◽  
Uva Radiation

Experimentally derived viscoelastic properties of human skin and muscle in vitro

2018 ◽  
Vol 61 ◽  
pp. 25-31 ◽  
Author(s):  
Moon Jeong Kang ◽  
Bo-seung Kim ◽  
Sejin Hwang ◽  
Hong Hee Yoo
Keyword(s):  
Human Skin ◽  
Viscoelastic Properties

Desmosomal distribution in the epidermis of a non-contracting human skin equivalent

1992 ◽  
Vol 50 (1) ◽  
pp. 896-897
Author(s):  
L.X. Oakford ◽  
S.D. Dimitrijevich ◽  
R. Gracy
Keyword(s):  
Human Skin ◽  
Basal Layer ◽  
Skin Equivalent ◽  
Tissue Component ◽  
Intact Skin ◽  
Similar Sequence ◽  
Sequence Of Events ◽  
Suprabasal Keratinocytes ◽  
Human Skin Equivalent

In intact skin the epidermal layer is a dynamic tissue component which is maintained by a basal layer of mitotically active cells. The protective upper epidermis, the stratum corneum, is generated by differentiation of the suprabasal keratinocytes which eventually desquamate as anuclear comeocytes. A similar sequence of events is observed in vitro in the non-contracting human skin equivalent (HSE) which was developed in this lab (1). As a part of the definition process for this model of living skin we are examining its ultrastructural features. Since desmosomes are important in maintaining cell-cell interactions in stratified epithelia their distribution in HSE was examined.

Human Skin-Derived Fibroblasts Acquire In Vitro Anti-Tumor Potential after Priming with Paclitaxel

2013 ◽  
Vol 13 (3) ◽  
pp. 523-530 ◽  
Author(s):  
Augusto Pessina ◽  
Valentina Cocce ◽  
Arianna Bonomi ◽  
Loredana Cavicchini ◽  
Francesca Sisto ◽  
...  
Keyword(s):  
Human Skin

The Effect of Practolol, In Vitro Generated Metabolites of Practolol and Chemical Analogues on the Rate of Growth of Human Skin Fibroblasts

1984 ◽  
Vol 12 (2) ◽  
pp. 89-97
Author(s):  
Graham R. Elliott ◽  
H.E. Amos ◽  
James W. Bridges
Keyword(s):  
Human Skin ◽  
Psoriasis Patient ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Cell Type ◽  
Normal Human Skin ◽  
Rate Of Growth ◽  
Structural Analogues ◽  
Normal Human

The rate of growth of normal human skin fibroblasts was inhibited in a dose related, reversible, fashion by practolol (N-4-(2-hydroxy)-3 (1-methyl)-aminopropoxyphenylacetamine) (ID50 1.35 ± 0.14 x 10-3M), propranolol (1-(isopropylamino)-3(1-naphthyl-oxy)-2-propranolol) (ID50 0.145 ± 0.02 x 10-3M) and paracetamol (N-(4-hydroxyphenyl) acetamide) (ID50 0.85 ± 0.2 x 10-3M). Skin fibroblasts isolated from a psoriasis patient were more sensitive towards practolol (ID50 0.48 ± 0.14 x 10-3M) and propranolol (ID50 0.032 ± 0.002 x 10-3M), but less sensitive towards paracetamol (ID50 1.3 ± 0.07 x 10-3M). In vitro generated metabolites of practolol, using normal or Arochlor 1254-pretreated hamster liver preparations, and structural analogues of practolol had no effect upon the growth of either cell type.

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