Novel nanostructured resin infiltrant containing calcium phosphate nanoparticles to prevent enamel white spot lesions

Objective: The aim of this study was to evaluate the remineralization effect of Casein Phosphopeptid Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions (WSL) and its inhibitory effect on Streptococcus mutans colonization. Study design: The study group consisted of 60 children exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: a test group of using CPP-ACP cream (Tooth Mousse, GC Europe N.V., Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-months. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva sample collection was repeated. Wilcoxon Signed Ranks Test was used for statistical analysis. Results: DIAGNOdent measurements were increased by time (p=0.002) in control group and no statistically significant difference (p=0.217) was found in test group by the 3-month period. In both groups, the mutans counts were decreased in 3-month experimental period. Conclusions: These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however longer observation is recommended to confirm whether the greater change in WSLs is maintained.

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BOND FAILURE RATE OF AMORPHOUS CALCIUM PHOSPHATE CONTAINING (AEGIS ORTHO) AND FLUORIDE RELEASING (TRANSBOND PLUS COLOUR CHANGE) ORTHODONTIC ADHESIVES-A RANDOMIZED CLINICAL TRIAL

Journal of Indian Dental Association ◽

10.33882/jida.13.25277 ◽

2019 ◽

Author(s):

Shyamala Naidu ◽

Anand Suresh

Keyword(s):

Calcium Phosphate ◽

Failure Rate ◽

Amorphous Calcium Phosphate ◽

Age Groups ◽

Colour Change ◽

White Spot ◽

Rank Test ◽

White Spot Lesions ◽

Bond Failure ◽

Kaplan Meier

Background: The aim of the study was to compare the survival rate of brackets bonded with amorphous calcium phosphate containing adhesive and fluoride releasing orthodontic adhesive over 6 months period. White spot lesions were also evaluated prior to bonding, 3 months and 6 months from the date of bonding. Methods: Thirty six orthodontic patients were randomly divided into two equal groups using split mouth design. 592 brackets were bonded up to the premolars with either Aegis Ortho or Transbond Colour Change(TPCCA). Bracket failure rate and survival distribution were evaluated and compared using Kaplan- meier analysis and Log rank test with respect to adhesives, dental arches, segments , tooth types, gender and age groups. White spot lesion was assessed using WSL index. Results: There was no significant difference between the failure rate of Aegis Ortho(3.0%) and TPCCA(1.4%). Kaplan Meier analysis, Log rank test showed that the difference in the overall failure rate and survival time between the arches, gender, and different age groups were not statistically significant. Both adhesives had a high bond failure rate in the posterior segment especially in the premolar region. Three patients had white spot lesions in the upper premolar region bonded with Aegis ortho. Conclusion: Both Aegis ortho and Transbond plus colour change adhesive with a low bond failure rate can be used as an alternative orthodontic adhesive. Key words : bond failure, amorphous calcium phosphate, transbond colour change adhesive, white spot lesions.

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Effectiveness of Casein Phosphopeptide-Amorphous Calcium Phosphate on the Prevention of White Spot Lesions: A Systematic Review and Meta-Analysis

Iranian Journal of Orthodontics ◽

10.5812/ijo.7194 ◽

2016 ◽

Vol 12 (2) ◽

Cited By ~ 2

Author(s):

Defne Kecik

Keyword(s):

Systematic Review ◽

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Meta Analysis ◽

White Spot ◽

White Spot Lesions ◽

Casein Phosphopeptide

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An In Vitro Study on the Effect of Amorphous Calcium Phosphate and Fluoride Solutions on Color Improvement of White Spot Lesions

Dentistry Journal ◽

10.3390/dj6030024 ◽

2018 ◽

Vol 6 (3) ◽

pp. 24 ◽

Cited By ~ 1

Author(s):

Fahimeh Farzanegan ◽

Hamideh Ameri ◽

Ilnaz Miri Soleiman ◽

Elham Khodaverdi ◽

Abdolrasoul Rangrazi

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

In Vitro Study ◽

Vitro Study ◽

White Spot ◽

White Spot Lesions

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Treatment of post-orthodontic white spot lesions with casein phosphopeptide-stabilised amorphous calcium phosphate

Clinical Oral Investigations ◽

10.1007/s00784-010-0401-2 ◽

2010 ◽

Vol 15 (3) ◽

pp. 369-373 ◽

Cited By ~ 60

Author(s):

Ann Bröchner ◽

Carsten Christensen ◽

Bjarne Kristensen ◽

Sofia Tranæus ◽

Lena Karlsson ◽

...

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

White Spot ◽

White Spot Lesions ◽

Casein Phosphopeptide

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ENAMEL SURFACE QUALITY IMPROVEMENT IN WHITE SPOT LESIONS AFTER ORTHODONTIC TREATMENT USING A MICROABRASION TECHNIQUE WITH FLUORIDE OR CALCIUM PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE APPLICATION

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2017.v9s2.28 ◽

2018 ◽

Vol 9 ◽

pp. 114

Author(s):

Novira Mutia Safitri ◽

Haru Setyo Anggani ◽

Miesje Karmiati Purwanegara ◽

Sariesendy Sumardi

Keyword(s):

Surface Roughness ◽

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Orthodontic Treatment ◽

Enamel Surface ◽

White Spot ◽

White Spot Lesions ◽

Significant Difference ◽

Before And After ◽

Bacterial Plaque

Objectives: White spot lesions after fixed orthodontic treatment will increase bacterial plaque formation due to increased enamel surface roughness. The aim of this study was to analyze the surface roughness of white spot lesions on enamel after a microabrasion technique, a microabrasion technique combined with calcium phosphopeptide-amorphous calcium phosphate (CPP-ACP) application, and a microabrasion technique combined with fluoride application.Methods: Artificially induced white spot lesions on the enamel surfaces of 42 maxillary first premolars were randomly assigned into one of three treatment groups (n=14): (a) A microabrasion technique, (b) a microabrasion technique combined with CPP-ACP application, and (c) a microabrasion technique combined with fluoride application. A Mitutoyo SJ-301 surface roughness tester was used to measure differences in surface roughness before and after treatment, and the after treatment measurements were compared among the three groups.Results: A significant difference in surface roughness was noted for the white spot lesions on enamel before and after treatment in all groups (p<0.05). A significant difference was also found when comparing the after treatment surface roughness in all groups.Conclusion: The combination of the microabrasion technique with CPP-ACP application significantly reduced enamel surface roughness when compared to microabrasion alone or the combination of microabrasion and fluoride application.

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