Porous Fe3O4-SiO2 core-shell nanorods as high-performance MRI contrast agent and drug delivery vehicle

2017 ◽  
Vol 428 ◽  
pp. 340-347 ◽  
Author(s):  
Muhammad Shahbaz Beg ◽  
Jeotikanta Mohapatra ◽  
Lina Pradhan ◽  
D. Patkar ◽  
D. Bahadur
Keyword(s):  
Drug Delivery ◽  
Contrast Agent ◽  
High Performance ◽  
Mri Contrast Agent ◽  
Core Shell ◽  
Delivery Vehicle ◽  
Mri Contrast ◽  
Drug Delivery Vehicle

scholarly journals Theragnostic Magnetic Core-Shell Nanoparticle as Versatile Nanoplatform for Magnetic Resonance Imaging and Drug Delivery

2021 ◽  
Vol 11 (5) ◽  
pp. 13276-13289
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Scanning Electron Microscopy ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Magnetic Core ◽  
Mri Contrast Agent ◽  
Core Shell ◽  
Mri Contrast ◽  
Scanning Electron

In this study, magnetic core-shell (MCS) nanoparticles were prepared as theragnostic potential nanoplatforms for simultaneously targeted drug delivery systems for tamoxifen and diagnosis. MCS nanoparticles were prepared in a well-shaped spherical form by the o/w emulsion method and characterized by means of dynamic light scattering (DLS), Scanning electron microscopy (SEM), Nuclear magnetic resonance (NMR), transform infrared (FT-IR) spectroscopy, and vibrating sample magnetometer (VSM). Scanning electron microscopy (SEM) indicated spherical nanostructures' formation with the final average particle size of around 80 nm. The findings proved the superparamagnetic properties of the MCS nanoparticles with relatively high-magnetization values (11.69 emu/g), which indicate that they were sensitive enough to external magnetic fields as a magnetic drug carrier. The nanoparticles showed 8.14% and 52.19% drug loading and encapsulation efficiency, respectively. MCS nanoparticles showed sustained release behavior for 120 h in the phosphate-buffered saline (PBS, pH= 7.4, 5.4) at 37 °C. The ratio between transverse and longitudinal relaxivity (r2/r1) value of the MCS nanoparticles was around 20, indicating their potential as a T2 MRI contrast agent. It can be concluded that the prepared MCS nanoparticles may serve as a promising carrier as an MRI contrast agent and targeted controlled anticancer drug delivery.

MONODISPERSED SILICA NANOSPHERES ENCAPSULATING Fe3O4 AND LaF3:Eu3+ NANOPARTICLES FOR MRI CONTRAST AGENT AND LUMINESCENT IMAGING

2013 ◽  
Vol 06 (01) ◽  
pp. 1250052 ◽  
Author(s):  
YANG TIAN ◽  
BINBIN YU ◽  
HONG-YU YANG ◽  
JI LIAO
Keyword(s):  
Contrast Agent ◽  
High Performance ◽  
Small Diameter ◽  
Luminescent Properties ◽  
Mri Contrast Agent ◽  
Cell Uptake ◽  
X Ray Diffraction ◽  
Mri Contrast ◽  
Bio Imaging ◽  
20 Nm

Bifunctional nanospheres of silica encapsulating Fe3O4 and LaF3 : Eu nanoparticles were synthesized in a reverse microemulsion solution. The nanospheres were perfectly monodispersed with a small diameter of 20 nm. The composition of the bifunctional nanospheres was confirmed by powder X-ray diffraction. Their magnetic and luminescent properties were measured at room temperature. The relaxation efficiency and T2-weighted images showed the high-performance for the product as a resonance imaging contrast agent. In addition, a qualitative cell uptake in human cervical cancer HeLa cells demonstrated that the SFLE nanospheres were efficiently up-taken into cytosol. Taken together, these findings suggest that the SiO2 / Fe3O4 - LaF3 : Eu 3+ nanospheres are good luminescence probes for bio-imaging.

Microextraction of Gadolinium MRI contrast agent using core-shell Fe3O4@SiO2 nanoparticles: optimization of adsorption conditions and in-vitro study

2019 ◽  
Vol 12 ◽  
pp. 100250
Author(s):  
Matin Naghizadeh ◽  
Mohammad Ali Taher ◽  
Ali-Mohammad Tamaddon ◽  
Sedigheh Borandeh ◽  
Samira Sadat Abolmaali
Keyword(s):  
Contrast Agent ◽  
In Vitro Study ◽  
Sio2 Nanoparticles ◽  
Vitro Study ◽  
Mri Contrast Agent ◽  
Core Shell ◽  
Mri Contrast

scholarly journals Enhanced MRI relaxivity of aquated Gd3+ ions by carboxyphenylated water-dispersed graphene nanoribbons

Nanoscale ◽  
2014 ◽  
Vol 6 (6) ◽  
pp. 3059-3063 ◽  
Author(s):  
Ayrat Gizzatov ◽  
Vazrik Keshishian ◽  
Adem Guven ◽  
Ayrat M. Dimiev ◽  
Feifei Qu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
High Performance ◽  
Graphene Nanoribbons ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Enhanced Mri

The present study demonstrates a new high-performance MRI contrast agent with r1 = 70 and r2 = 108 mM−1 s−1 for applications in T1- and T2-weighted imaging.

The gadonanotubes: structural origin of their high-performance MRI contrast agent behavior

2013 ◽  
Vol 1 (42) ◽  
pp. 5791 ◽  
Author(s):  
Qing Ma ◽  
Meghan Jebb ◽  
Michael F. Tweedle ◽  
Lon J. Wilson
Keyword(s):  
Contrast Agent ◽  
High Performance ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Agent Behavior

Development of Gold-Coated Magnetic Nanoparticles as a Potential MRI Contrast Agent

NANO ◽  
2015 ◽  
Vol 10 (04) ◽  
pp. 1550048 ◽  
Author(s):  
Ali Reza Montazerabadi ◽  
Mohammad Ali Oghabian ◽  
Rasoul Irajirad ◽  
Samad Muhammadnejad ◽  
Davoud Ahmadvand ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Early Stage ◽  
Superparamagnetic Iron Oxide ◽  
In Vitro Cytotoxicity ◽  
Mri Contrast Agent ◽  
Core Shell ◽  
Mri Contrast ◽  
Shell Particles

Gold-coated superparamagnetic iron oxide nanoparticles (SPIONs) coated with methyl-polyethylene glycol (mPEG) are synthesized and investigated as a magnetic resonance (MR) imaging contrast agent. The synthesized mPEG-core@shells are characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometry (VSM), zeta-potential analysis and X-ray diffraction (XRD). In addition, the transverse relaxivity of the mPEG-core@shells is measured using a 3 T MRI scanner. The cytotoxicity of the mPEG-core@shells is tested in the LNCaP cell line using an 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that the mPEG-core@shell particles are semispherical with hydrodynamic size of ∼ 65 nm and a transverse relaxivity of 162.3 mM-1 S-1. The mPEG-core@shell particles demonstrate good stability in biological media without any significant in vitro cytotoxicity under high cellular uptake conditions. Finally, in vivo imaging shows that mPEG-core@shells are a potential contrast agent for use in early-stage detection.

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