Evidence of substance P autocrine circuitry that involves TNF-α, IL-6, and PGE2 in endogenous pyrogen-induced fever

2016 ◽  
Vol 293 ◽  
pp. 1-7 ◽  
Author(s):  
Haissa Oliveira Brito ◽  
Felipe L. Barbosa ◽  
Renata Cristiane dos Reis ◽  
Daniel Fraga ◽  
Beatriz S. Borges ◽  
...  
Keyword(s):  
Substance P ◽  
Endogenous Pyrogen ◽  
Tnf Α

scholarly journals Substance P induces TNF-α and IL-6 production through NFκB in peritoneal mast cells

2003 ◽  
Vol 1643 (1-3) ◽  
pp. 75-83 ◽  
Author(s):  
Antonina Azzolina ◽  
Antonella Bongiovanni ◽  
Nadia Lampiasi
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Tnf Α ◽  
Peritoneal Mast Cells

scholarly journals Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Allodynia and Suppresses Spinal Substance P and Proinflammatory Cytokine Release in Rats

2015 ◽  
Vol 95 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Yu-Wen Chen ◽  
Jann-Inn Tzeng ◽  
Min-Fei Lin ◽  
Ching-Hsia Hung ◽  
Jhi-Joung Wang
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Proinflammatory Cytokines ◽  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Necrosis Factor Alpha ◽  
Electrical Nerve Stimulation ◽  
Mechanical Hypersensitivity ◽  
Quick Recovery ◽  
Tnf Α

BackgroundTranscutaneous electrical nerve stimulation (TENS) is often used for management of chronic pain.ObjectiveThe purpose of this study was to investigate whether TENS altered postincisional allodynia, substance P, and proinflammatory cytokines in a rat model of skin-muscle incision and retraction (SMIR).DesignThis was an experimental study.MethodsHigh-frequency (100-Hz) TENS therapy began on postoperative day 3 and was administered for 20 minutes daily to SMIR-operated rats by self-adhesive electrodes delivered to skin innervated via the ipsilateral dorsal rami of lumbar spinal nerves L1–L6 for the next 27 days. The expressions of substance P, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β) in the spinal cord and mechanical sensitivity to von Frey stimuli (4g and 10g) were evaluated.ResultsThe SMIR-operated rats displayed a marked hypersensitivity to von Frey stimuli on postoperative day 3. In contrast to the SMIR-operated rats, SMIR-operated rats after TENS administration showed a quick recovery of mechanical hypersensitivity. On postoperative days 3, 16, and 30, SMIR-operated rats exhibited an upregulation of substance P and cytokines (TNF-α, IL-6, and IL-1β) in the spinal cord, whereas SMIR-operated rats after TENS therapy inhibited that upregulation. By contrast, the placebo TENS following SMIR surgery did not alter mechanical hypersensitivity and the levels of spinal substance P, TNF-α, IL-6, and IL-1β.LimitationsThe experimental data are limited to animal models and cannot be generalized to postoperative pain in humans.ConclusionsThe results revealed that TENS attenuates prolonged postoperative allodynia following SMIR surgery. Increased levels of spinal substance P and proinflammatory cytokines, activated after SMIR surgery, are important in the processing of persistent postsurgical allodynia. The protective effect of TENS may be related to the suppression of spinal substance P and proinflammatory cytokines in SMIR-operated rats.

INVOLVEMENT OF p38 AND JNK MAPKs PATHWAYS IN SUBSTANCE P-INDUCED PRODUCTION OF TNF-α BY PERITONEAL MAST CELLS

Cytokine ◽  
2002 ◽  
Vol 18 (2) ◽  
pp. 72-80 ◽  
Author(s):  
Antonina Azzolina ◽  
Patrizia Guarneri ◽  
Nadia Lampiasi
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Tnf Α ◽  
Peritoneal Mast Cells

Human Skin Mast Cells Produce TNF-α by Substance P

1998 ◽  
Vol 117 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Yoshimichi Okayama ◽  
Yoshihiro Ono ◽  
Tsugio Nakazawa ◽  
Martin Church ◽  
Masatomo Mori
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Human Skin ◽  
Tnf Α

scholarly journals Substance P reduces TNF-α-induced apoptosis in human tenocytes through NK-1 receptor stimulation

2013 ◽  
Vol 48 (19) ◽  
pp. 1414-1420 ◽  
Author(s):  
Ludvig J Backman ◽  
Daniella E Eriksson ◽  
Patrik Danielson
Keyword(s):  
Substance P ◽  
Receptor Stimulation ◽  
Tnf Α ◽  
Induced Apoptosis

Substance P selectively activates TNF-α mRNA in rat uterine immune cells

Neuroreport ◽  
1997 ◽  
Vol 8 (13) ◽  
pp. 2961-2964 ◽  
Author(s):  
Roberta Cocchiara ◽  
Antonella Bongiovanni ◽  
Giuseppe Albeggiani ◽  
Antonina Azzolina ◽  
Domenico Geraci
Keyword(s):  
Substance P ◽  
Immune Cells ◽  
Tnf Α

scholarly journals Involvement of leukotrienes, TNF-α, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration

1997 ◽  
Vol 61 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Marcia R. Saban ◽  
Ricardo Saban ◽  
Dale Bjorling ◽  
Mary Haak-Frendscho
Keyword(s):  
Substance P ◽  
Granulocyte Infiltration ◽  
Tnf Α

scholarly journals Neuropeptid Y és P anyag immunreaktív idegrostok és immunkompetens sejtek változása hepatitisben

2015 ◽  
Vol 156 (47) ◽  
pp. 1892-1897
Author(s):  
Erzsébet Fehér
Keyword(s):  
Substance P ◽  
Neuropeptide Y ◽  
Immune Cells ◽  
Tumor Necrosis ◽  
Nuclear Factor ◽  
Nerve Fibres ◽  
Tnf Α ◽  
Inflammatory Processes ◽  
Factor Α ◽  
Necrosis Factor

Neuropeptide Y and substance P were thought to play a role in the function of immune cells and in amplification or elimination of the inflammatory processes. In hepatitis the number of both neuropeptide Y and substance P immunoreactive nerve fibres are increased, where the increase of neoropeptide Y is significant. A large number of lymphocytes and mast cells are also stained for neuropeptide Y and substance P. Very close associations (less than 1 µm) were observed between neuropeptide Y immunoreactive nerve fibres and immune cells stained also with neuropeptide Y. Some immune cells were also found to be immunoreactive for tumor necrosis factor-α and NF-κB. Some of the SP IR immunocells were also stained for TNF-α and nuclear factor kappaB. Based on these data it is hypothesized that neuropeptid Y and substance P released from nerve fibres and immune cells play a role in inflammation and elimination of inflammation in hepatitis. Orv. Hetil., 2015, 156(47), 1892–1897.

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