Anxiety and depression severity are related to right but not left onset Parkinson's disease duration

The objectives of the study were to analyze the association between Parkinson’s disease and restless legs syndrome, and explore the relationship between mood disorder comorbidity (anxiety and depression), pain, and restless legs syndrome. This study included 123 Parkinson’s disease patients and 123 healthy controls matched for age and gender, and evaluated for anxiety severity, depression severity, pain severity, pain interference, pain disability, and restless legs syndrome prevalence. This was performed using semi-structured interviews and a neurological examination. Restless Legs Syndrome diagnostic criteria and the following inventories were used; Hospital Anxiety and Depression Scale, Brief Pain Inventory, and Pain Disability Index. Parkinson’s disease patients had significantly greater anxiety severity, depression severity, pain severity, pain interference, pain disability, and restless legs syndrome prevalence in comparison to controls. In addition, Parkinson’s disease patients’ comorbid for anxiety and depression had significantly greater pain severity, pain interference, and pain disability, but not RLS prevalence, in comparison to Parkinson’s disease only, Parkinson’s disease anxiety, and Parkinson’s disease depression patients. Pain interference, pain severity, and pain disability is greater among Parkinson’s disease patients with anxiety and depression, in comparison to Parkinson’s disease patients without anxiety and depression. On the contrary, the prevalence of restless legs syndrome was not found to be relevant.

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Drooling, Swallowing Difficulties and Health Related Quality of Life in Parkinson’s Disease Patients

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158138 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8138

Author(s):

Gladis Yohana Arboleda-Montealegre ◽

Roberto Cano-de-la-Cuerda ◽

César Fernández-de-las-Peñas ◽

Carlos Sanchez-Camarero ◽

Ricardo Ortega-Santiago

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Duration ◽

Health Related Quality ◽

Nonmotor Symptoms ◽

Related Quality ◽

Health Related ◽

Swallowing Difficulties

Background: Parkinson’s disease (PD) is the most common neurodegenerative disorder associated with motor and nonmotor symptoms. Drooling, one of the nonmotor symptoms, can be present in 70–80% of patients with PD. The aim of this paper is to study the characteristics of PD patients with drooling compared to those without in terms of age, gender, disease duration, stage of the disease, swallowing difficulties, and health-related quality of life; methods: a cross-sectional study was conducted. The sample was divided into two groups: PD with drooling (n = 32) and PD without drooling (n = 30). Age, gender, disease duration and Hoehn & Yahr (H & Y) stage, Sialorrhea Clinical Scale for Parkinson’s Disease (SCS-PD), the 10-item Eating Assessment Tool (EAT-10), and the 39-item Parkinson’s Disease Questionnaire (PDQ-39) were compared between groups; Results: 62 individuals with PD, 40 men and 22 women (mean age 73 ± 8 years), were included. Overall, 32 patients reported drooling, and 30 did not exhibit it. The ANCOVA found significant differences between groups for the EAT-10 score (0.83, 95% CI = 5.62–9.03; p = 0.016) and SCS-PD score (1.48, 95% CI = 0.86–6.81; p < 0.001). Analysis of the PDQ-39 scores revealed no significant differences between groups for the PDQ-39 total score (p > 0.057) and in all subscales. The inclusion of gender, age, disease duration, and H & Y as covariates did not influence the results (all p > 0.05). Conclusions: drooling is related to swallowing difficulties assessed with EAT-10 but not with health-related quality of life assessed with PDQ-39 in PD patients with drooling compared to PD patients without it. Age, gender, duration of the disease, and the H & Y state of PD patients with and without drooling seem to be similar.

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Self-Perception of Voice and Swallowing Handicap in Parkinson’s Disease

Journal of Parkinson s Disease ◽

10.3233/jpd-212621 ◽

2021 ◽

pp. 1-8

Author(s):

Alice K. Silbergleit ◽

Lonni Schultz ◽

Kendra Hamilton ◽

Peter A. LeWitt ◽

Christos Sidiropoulos

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Duration ◽

Self Perception ◽

Functional Aspects ◽

Dysphagia Handicap Index ◽

Relationship Of ◽

The Relationship

Background: Hypokinetic dysarthria and dysphagia are known features of Parkinson’s disease; however, self-perception of their handicapping effects on emotional, physical, and functional aspects of quality of life over disease duration is less understood. Objective: 1) Based upon patient self-perception, to determine the relationship of the handicapping effects of dysphagia and dysphonia with time since diagnosis in individuals with Parkinson’s disease; 2)To determine if there is a relationship between voice and swallowing handicap throughout the course of Parkinson’s disease. Method: 277 subjects completed the Dysphagia Handicap Index and the Voice Handicap Index. Subjects were divided into three groups based on disease duration: 0–4 years, 5–9 years, and 10 + years. Results: Subjects in the longer duration group identified significantly greater perceptions of voice and swallowing handicap compared to the shorter duration groups. There was a significant positive correlation between the DHI and VHI. Conclusion: Self-perception of swallowing and voice handicap in Parkinson’s disease are associated with later stages of disease and progress in a linear fashion. Self-perception of voice and swallowing handicap parallel each other throughout disease progression in Parkinson’s disease. Individuals may be able to compensate for changes in voice and swallowing early while sensory perceptual feedback is intact. Results support early targeted questioning of patient self-perception of voice and swallowing handicap as identification of one problem indicates awareness of the other, thus creating an opportunity for early treatment and maintenance of swallowing and communication quality of life for as long as possible.

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Regional cerebral blood flow changes in Parkinson's disease: correlation with disease duration

Revista Española de Medicina Nuclear (English Edition) ◽

10.1016/s1578-200x(09)70019-1 ◽

2009 ◽

Vol 28 (3) ◽

pp. 114-120

Author(s):

M. Kapitán ◽

R. Ferrando ◽

E. Diéguez ◽

O. de Medina ◽

R. Aljanati ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Disease Duration ◽

Regional Cerebral Blood ◽

Flow Changes

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IMPACT OF DISEASE DURATION AND CARDIOVASCULAR DYSAUTONOMIA ON HYPERTENSION IN PARKINSON’S DISEASE

The Gerontologist ◽

10.1093/geront/gnw162.1745 ◽

2016 ◽

Vol 56 (Suppl_3) ◽

pp. 438-438

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Duration

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Clinical issues in the treatment of anxiety and depression in older adults with Parkinson's disease

Movement Disorders ◽

10.1002/mds.25689 ◽

2013 ◽

Vol 28 (14) ◽

pp. 1930-1934 ◽

Cited By ~ 38

Author(s):

Nancy A. Pachana ◽

Sarah J. Egan ◽

Ken Laidlaw ◽

Nadeeka Dissanayaka ◽

Gerard J. Byrne ◽

...

Keyword(s):

Older Adults ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Anxiety And Depression ◽

Clinical Issues

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A.01 Parkinson’s disease prognosis by early motor subtypes

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2018.82 ◽

2018 ◽

Vol 45 (s2) ◽

pp. S9-S9

Author(s):

N Hey ◽

ML Rajput ◽

AH Rajput ◽

A Rajput

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Symptom Onset ◽

Primary Outcome ◽

Disease Duration ◽

Motor Symptom ◽

Future Studies ◽

Disease Prognosis ◽

Significant Difference

Background: Studies of autopsy-confirmed cases suggest that Parkinson’s disease (PD) prognosis can be predicted using motor symptom severity at first visit. We evaluated the association between motor symptom subtype at first visit and severity at eight years disease duration among clinically-diagnosed cases at the Saskatchewan Movement Disorder Program. Methods: Retrospective data review identified 374 patients with first visit within three years of symptom onset, a clinical diagnosis of idiopathic PD, and a follow-up visit eight years after symptom onset. Subtypes were grouped as tremor-dominant (TD) if tremor was greater than rigidity and bradykinesia, akinetic-rigid (AR) if rigidity or bradykinesia was greater than tremor, and mixed (MX) if patient was neither TD nor AR based on assessment of all four limbs. Primary outcome was disease severity as measured by Hoehn & Yahr score at eight years after symptom onset. Results: The most common subtype was AR (n=164) followed by MX (n=156). TD was least common (n=54). There was no significant difference between subtypes in H&Y scores at eight years disease duration. Conclusions: These findings suggest that early PD prognosis cannot be predicted based on motor symptoms in all four limbs at first visit. Earlier studies had longer follow-up and future studies will examine progression at longer periods of disease duration.

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P.042 Associations of pain and depression with marital status in patients diagnosed with Parkinson’s disease

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2016.146 ◽

2016 ◽

Vol 43 (S2) ◽

pp. S31-S31

Author(s):

A Rana ◽

I Abdullah ◽

AM Qureshi ◽

A Mumtaz ◽

M A. Rana

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Marital Status ◽

Depression Scale ◽

Brief Pain Inventory ◽

Pain Interference ◽

Control Group ◽

Depression Severity ◽

Single Group ◽

Depression Prevalence

Background: Depression and pain are significant clinical problems that are comorbid with Parkinson’s disease (PD). However, the relationship of these variables with the marital status of patients with PD has not been explored in previous studies. The goal of this study was to assess the possible relationship between depression prevalence, depression severity, and pain interference with the marital status of the sufferers of PD. Methods: This study included 40 patients and 40 healthy control participants who were assessed for depression prevalence and pain interference using The Hospital Anxiety and Depression Scale and the Brief Pain Inventory, respectively. Results: When compared to the control groups, the PD (Single) group was found to have the highest prevalence of depression, followed by the PD (Married) group whereas the Control (Single) group was found to have a higher prevalence than the Control (Married) group (P<0.0001). A main effect was found on depression severity (P<0.0001), but no significant differences were observed between the PD groups. Lastly, PD (Single) patients had significantly greater pain interference scores than the PD (Married) patients (P<0.05) with no other significant case-control or control-control group differences. Conclusions: Patient-spouse relationship may have a mitigating effect on patient outcomes of depression prevalence and pain interference.

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