Left thalamus infarction in the thalamotuberal artery perfusion area causing subcortical diaschisis and transcortical sensory aphasia

AbstractWe previously identified the inhibitory serpin protease nexin-1 (PN-1) as an important player of the angiogenic balance with anti-angiogenic activity in physiological conditions. In the present study, we aimed to determine the role of PN-1 on pathological angiogenesis and particularly in response to ischemia, in the mouse model induced by femoral artery ligation. In wild-type (WT) muscle, we observed an upregulation of PN-1 mRNA and protein after ischemia. Angiography analysis showed that femoral artery perfusion was more rapidly restored in PN-1−/− mice than in WT mice. Moreover, immunohistochemistry showed that capillary density increased following ischemia to a greater extent in PN-1−/− than in WT muscles. Moreover, leukocyte recruitment and IL-6 and MCP-1 levels were also increased in PN-1−/− mice compared to WT after ischemia. This increase was accompanied by a higher overexpression of the growth factor midkine, known to promote leukocyte trafficking and to modulate expression of proinflammatory cytokines. Our results thus suggest that the higher expression of midkine observed in PN-1- deficient mice can increase leukocyte recruitment in response to higher levels of MCP-1, finally driving neoangiogenesis. Thus, PN-1 can limit neovascularisation in pathological conditions, including post-ischemic reperfusion of the lower limbs.

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Direct coronary artery surgery with distal coronary artery perfusion

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/s0022-5223(19)42481-1 ◽

1970 ◽

Vol 59 (3) ◽

pp. 438-442 ◽

Cited By ~ 1

Author(s):

Roque Pijarré ◽

William E. Neville ◽

Khushroo E. Patel ◽

Robert D. Lynch ◽

T.K. Raghunath ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Surgery ◽

Artery Perfusion

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Selective pulmonary artery perfusion with melphalan is equal to isolated lung perfusion but superior to intravenous melphalan for the treatment of sarcoma lung metastases in a rodent model

European Journal of Cardio-Thoracic Surgery ◽

10.1093/ejcts/ezs017 ◽

2012 ◽

Vol 42 (2) ◽

pp. 341-347 ◽

Cited By ~ 6

Author(s):

W. A. Den Hengst ◽

J. M. H. Hendriks ◽

T. Van Hoof ◽

K. Heytens ◽

G. Guetens ◽

...

Keyword(s):

Pulmonary Artery ◽

Lung Metastases ◽

Lung Perfusion ◽

Rodent Model ◽

Isolated Lung Perfusion ◽

Isolated Lung ◽

Artery Perfusion

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Posteroventral pallidotomy for midbrain tremor after a pontine hemorrhage

Journal of Neurosurgery ◽

10.3171/jns.1999.91.5.0885 ◽

1999 ◽

Vol 91 (5) ◽

pp. 885-888 ◽

Cited By ~ 34

Author(s):

Yasushi Miyagi ◽

Fumio Shima ◽

Katsuya Ishido ◽

Masashi Moriguchi ◽

Kazufumi Kamikaseda

Keyword(s):

Upper Extremity ◽

High Frequency ◽

Upper Extremities ◽

Proximal Segment ◽

Action Tremor ◽

Content Type ◽

Pontine Hemorrhage ◽

Posteroventral Pallidotomy ◽

Left Thalamus ◽

Midbrain Tremor

✓ This 49-year-old man gradually developed a disabling action tremor in the proximal right upper extremity 8 months after suffering a pontine tegmental hemorrhage. The intraoperative microrecording in the nucleus ventralis intermedius (VIM) of the left thalamus revealed tremor-synchronous grouped discharges with a vigorous (2.7 Hz) action tremor predominantly in the shoulder and upper arm. High frequency electrical stimulation in the VIM did not affect the tremor. A posteroventral pallidotomy (PVP) was performed and resulted in the successful alleviation of all tremor activity. Posteroventral pallidotomy is known to alleviate parkinsonian tremors, especially those occurring in the contralateral lower extremity, trunk, and proximal segment of the contralateral upper extremity. The authors consider the pallidoreticular pathway to be an important tremor-mediating pathway for the proximal segment of the upper extremities and believe it can be controlled more effectively by PVP than by VIM thalamotomy, as demonstrated by the PVP-induced resolution of the midbrain tremor observed in this case.

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On‐table fenestration of frozen elephant trunk graft to achieve aberrant subclavian artery perfusion

ANZ Journal of Surgery ◽

10.1111/ans.17372 ◽

2021 ◽

Author(s):

Zhefeng Kang ◽

Jun Shi ◽

Yingqiang Guo

Keyword(s):

Subclavian Artery ◽

Frozen Elephant Trunk ◽

Elephant Trunk ◽

Aberrant Subclavian Artery ◽

Artery Perfusion

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ALCAPA: The Al Capone of coronary artery anomalies

South African Journal of Radiology ◽

10.4102/sajr.v16i3.290 ◽

2012 ◽

Vol 16 (3) ◽

pp. 100-101 ◽

Cited By ~ 1

Author(s):

Farzanah Ismail

Keyword(s):

Coronary Artery ◽

Mortality Rate ◽

Left Coronary Artery ◽

First Year ◽

Coronary Artery Anomalies ◽

Perfusion System ◽

Anomalous Left Coronary Artery ◽

First Year Of Life ◽

Anomalous Left Coronary ◽

Artery Perfusion

Anomalous left coronary artery originating from the pulmonary artery (ALCAPA) is a rare coronary artery anomaly that presents with myocardial ischaemia or infarction and/or cardiac failure in infants. It is associated with a mortality rate of 90% within the first year of life. Surgical correction to re-establish a two-coronary artery perfusion system is the treatment of choice, once patients are medically stable.

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Blood-brain barrier transport of neuropeptides: analysis with a metabolically stable dermorphin analogue

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1994.267.1.e124 ◽

1994 ◽

Vol 267 (1) ◽

pp. E124-E131 ◽

Cited By ~ 6

Author(s):

A. Samii ◽

U. Bickel ◽

U. Stroth ◽

W. M. Pardridge

Keyword(s):

Carotid Artery ◽

Internal Carotid Artery ◽

Intravenous Injection ◽

Internal Carotid ◽

Lipid Solubility ◽

Permeability Surface ◽

Bbb Permeability ◽

The Brain ◽

Artery Perfusion ◽

Internal Carotid Artery Perfusion

To avoid the confounding effect of metabolic degradation, the stable mu-opioid peptide agonist [D-Arg2,Lys4]-dermorphin analogue (DALDA) was used to quantitate blood-brain barrier (BBB) permeability by intravenous injection and internal carotid artery perfusion techniques. With intravenous injection, the BBB permeability-surface area products for [3H]DALDA (0.84 +/- 0.13 microliters.min-1.g-1) and [14C]sucrose (0.39 +/- 0.05 microliters.min-1.g-1) correlated with the lipid solubility of the two molecules: the 1-octanol-Ringer partition coefficient for DALDA was approximately 2 log orders greater than that for sucrose. The brain delivery of [3H]DALDA at 30 min after intravenous administration was 0.019 +/- 0.002% of the injected dose per gram, and analgesia was induced with a 5-mg/kg dose administered systemically. In contrast to the result after intravenous injection, the BBB permeability-surface area product for DALDA estimated with the internal carotid artery perfusion technique was manyfold greater. This was due to nonspecific absorption of the peptide into the cerebral microvasculature, which precluded use of the capillary depletion technique to study transcytosis through the BBB after internal carotid artery perfusion. The present studies show that the brain delivery of a metabolically stable peptide, such as DALDA, is comparable to that for sucrose, correlates with lipid solubility, and is mediated by a nonsaturable mechanism, probably free diffusion.

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Hand Laser Perfusion Imaging to Assess Radial Artery Patency: A Pilot Study

Journal of Clinical Medicine ◽

10.3390/jcm7100319 ◽

2018 ◽

Vol 7 (10) ◽

pp. 319 ◽

Cited By ~ 1

Author(s):

Ciro Indolfi ◽

Francesco Passafaro ◽

Sabato Sorrentino ◽

Carmen Spaccarotella ◽

Annalisa Mongiardo ◽

...

Keyword(s):

Radial Artery ◽

Perfusion Imaging ◽

Diagnostic Testing ◽

Area Under The Curve ◽

Diagnostic Technique ◽

Artery Occlusion ◽

Before And After ◽

Coronary Procedures ◽

Transradial Catheterization ◽

Artery Perfusion

Objectives: To test a novel diagnostic technique to assess radial artery perfusion after transradial catheterization. Background: Despite being mostly asymptomatic, radial artery occlusion (RAO) is not a benign complication, and its diagnosis is frequently missed because it requires time-consuming diagnostic testing. We developed a novel operator-independent diagnostic test to assess RAO after coronary procedures through a transradial access (TRA) by means of hand Laser Perfusion Imaging (LPI). Methods: One hundred patients were evaluated before and after TRA by means of the LPI. A radial perfusion index (RPI) was calculated as the ratio between the total perfusion measured during ulnar occlusion and total basal perfusion. Vascular Duplex scan (VDS) was used as the standard of reference to assess the artery patency. Results: LPI correctly identified RAO in 100% of cases. Post-procedural RPI was 0.89 ± 0.13 in patients with radial patency vs. 0.15 ± 0.04 in patients with RAO (p < 0.001). In line with these results, ROC analysis showed an excellent diagnostic performance of the LPI, that correctly identified all RAO cases (Area Under the Curve, AUC = 1.0; p < 0.001), with an optimal diagnostic cutoff at 0.2 RPI. Conclusions: LPI is a reliable diagnostic technique for RAO, offering the advantages of being quick and simple to perform.

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