scholarly journals Ventral tegmental area disconnection contributes two years early to correctly classify patients converted to Alzheimer’s disease: Implications for treatment

2021 ◽  
Vol 429 ◽  
pp. 117784
Author(s):  
Laura Serra ◽  
Marcello D'Amelio ◽  
Carlotta Di Domenico ◽  
Giacomo Koch ◽  
Camillo Marra ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ventral Tegmental Area ◽  
Ventral Tegmental

scholarly journals Ventral tegmental area disruption in Alzheimer’s disease

Aging ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1325-1326
Author(s):  
Marco Bozzali ◽  
Marcello D’Amelio ◽  
Laura Serra
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ventral Tegmental Area ◽  
Ventral Tegmental

scholarly journals Reduced monoaminergic nuclei MRI signal detectable in pre-symptomatic older adults with future memory decline

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Annalena Venneri ◽  
Matteo De Marco
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Ventral Tegmental Area ◽  
Pharmacological Treatment ◽  
Functional Decline ◽  
Post Mortem ◽  
Murine Models ◽  
Clinical Dementia Rating ◽  
Memory Decline

Abstract Evidence from murine models and human post-mortem studies indicates that monoaminergic nuclei undergo degeneration at the pre-symptomatic stage of Alzheimer’s disease (AD). Analysing 129 datasets from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and relying on the Clinical Dementia Rating as group-defining instrument, we hypothesised that the MRI signal of monoaminergic nuclei would be a statistically significant predictor of memory decline in participants initially recruited in ADNI as healthy adults. As opposed to a group of cognitively stable participants, participants developing memory decline had reduced signal in the ventral tegmental area at baseline, before any evidence of functional decline emerged. These findings indicate that monoaminergic degeneration predates the onset of memory decline in an AD-centred initiative, with a crucial involvement of very-early changes of a dopaminergic region. This translates into potential informative avenues for pharmacological treatment of pre-symptomatic AD.

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

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