Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells

2008 ◽  
Vol 19 (3) ◽  
pp. 166-174 ◽  
Author(s):  
Sei-Jung Lee ◽  
Kye-Taek Lim
Keyword(s):  
Cell Death ◽  
Cytochrome C ◽  
Nuclear Factor Kappa B ◽  
Caspase 3 ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Hep3b Cells

scholarly journals Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor–kappa B activity

2013 ◽  
Vol 205 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Tara C.K. Krosch ◽  
Veena Sangwan ◽  
Sulagna Banerjee ◽  
Nameeta Mujumdar ◽  
Vikas Dudeja ◽  
...  
Keyword(s):  
Cell Death ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells

2018 ◽  
Vol Volume 12 ◽  
pp. 1053-1063 ◽  
Author(s):  
Menaga Subramaniam ◽  
Su Ki Liew ◽  
Lionel L.A. In ◽  
Khalijah Awang ◽  
Niyaz Ahmed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Nuclear Factor Kappa B ◽  
Drug Combinations ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

The role of curcumin as an inhibitor of oxidative stress caused by ischaemia re-perfusion injury in tetralogy of Fallot patients undergoing corrective surgery

2015 ◽  
Vol 26 (3) ◽  
pp. 431-438 ◽  
Author(s):  
Rubiana Sukardi ◽  
Sudigdo Sastroasmoro ◽  
Nurjati C. Siregar ◽  
Mulyadi M. Djer ◽  
Fransciscus D. Suyatna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tetralogy Of Fallot ◽  
Nuclear Factor Kappa B ◽  
Caspase 3 ◽  
Length Of Hospital Stay ◽  
Nuclear Factor ◽  
Corrective Surgery ◽  
Nuclear Factor Kappa ◽  
Significant Difference ◽  
Lower Temperature

AbstractBackgroundCardiopulmonary bypass during tetralogy of Fallot corrective surgery is associated with oxidative stress, and contributes to peri-operative problems. Curcumin has been known as a potent scavenger of reactive oxygen species, which enhances the activity of antioxidants and suppresses phosphorylation of transcription factors involved in inflamation and apoptosis.ObjectivesTo evaluate the effects of curcumin as an antioxidant by evaluating the concentrations of malondialdehyde and glutathione, activity of nuclear factor-kappa B, c-Jun N-terminal kinase, caspase-3, and post-operative clinical outcomes.MethodsTetralogy of Fallot patients for corrective surgery were randomised to receive curcumin (45 mg/day) or placebo orally for 14 days before surgery. Malondialdehyde and glutathione concentrations were evaluated during the pre-ischaemia, ischaemia, re-perfusion phases, and 6 hours after aortic clamping-off. Nuclear factor-kappa B, c-Jun N-terminal kinase, and caspase-3, taken from the infundibulum, were assessed during the pre-ischaemia, ischaemia, and re-perfusion phases. Haemodynamic parameters were monitored until day 5 after surgery.ResultsIn all the observation phases, malondialdehyde and glutathione concentrations were similar between groups. There was no significant difference in nuclear factor-kappa B activity between the groups for three observations; however, in the curcumin group, c-Jun N-terminal kinase significantly decreased from the pre-ischaemia to the re-perfusion phases, and caspase-3 expression was lower in the ischaemia phase. Patients in the curcumin group had lower temperature and better ventricular functions, but no significant differences were found in mechanical ventilation day or length of hospital stay in the two groups.ConclusionCardioprotective effects of curcumin may include inhibition of the c-Jun N-terminal kinase pathway and caspase-3 in cardiomyocytes, particularly in the ischaemia phase.

AN ESSENTIAL ROLE FOR NUCLEAR FACTOR KAPPA B IN PREVENTING TNF-alpha-INDUCED CELL DEATH IN PROSTATE CANCER CELLS

1999 ◽  
pp. 674-679 ◽  
Author(s):  
MAKOTO SUMITOMO ◽  
MASAAKI TACHIBANA ◽  
JUN NAKASHIMA ◽  
MASARU MURAI ◽  
AKIRA MIYAJIMA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Essential Role ◽  
Nuclear Factor Kappa B ◽  
Tnf Alpha ◽  
Nuclear Factor ◽  
Prostate Cancer Cells ◽  
Nuclear Factor Kappa

scholarly journals Differential roles of Yersinia outer protein P-mediated inhibition of nuclear factor-kappa B in the induction of cell death in dendritic cells and macrophages

2008 ◽  
Vol 57 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Irena Adkins ◽  
Sebastian Schulz ◽  
Stefan Borgmann ◽  
Ingo B. Autenrieth ◽  
Sabine Gröbner
Keyword(s):  
Cell Death ◽  
Dendritic Cells ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Iodide Uptake ◽  
Nuclear Factor Kappa ◽  
Dependent Inhibition ◽  
Mitogen Activated Protein ◽  
Dependent Cell ◽  
Antigen Presenting

Yersinia outer protein P (YopP) induces cell death in macrophages and dendritic cells (DC). In DC this YopP-dependent cell death coincides with the inhibition of nuclear factor-kappa B (NF-κB) activation. However, as shown by measurement of propidium iodide uptake via disrupted cellular membranes, the preincubation of DC with several NF-κB inhibitors prior to infection with Yersinia did not restore the death-inducing capacity of a YopP-deficient Yersinia mutant. These results suggest that in contrast to macrophages, in DC the YopP-dependent inhibition of NF-κB activation is not causative for the induction of cell death. Instead, in DC, the inhibition of mitogen-activated protein kinases (MAPKs), in particular, p38 and c-Jun N-terminal kinase, prior to infection with a YopP-deficient Yersinia mutant substituted the death-inducing capacity of the Yersinia wild-type strain, indicating that the YopP-dependent inhibition of MAPKs mediates Yersinia-induced DC death. The differences between DC and macrophages in the mechanisms of cell death induction by YopP presented herein might be crucial for the function of these antigen-presenting cells.

scholarly journals Cocaine induces cell death and activates the transcription nuclear factor kappa-b in pc12 cells

2009 ◽  
Vol 2 (1) ◽  
pp. 3 ◽  
Author(s):  
Lucilia B Lepsch ◽  
Carolina D Munhoz ◽  
Elisa M Kawamoto ◽  
Lidia M Yshii ◽  
Larissa S Lima ◽  
...  
Keyword(s):  
Cell Death ◽  
Pc12 Cells ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

AN ESSENTIAL ROLE FOR NUCLEAR FACTOR KAPPA B IN PREVENTING TNF-alpha-INDUCED CELL DEATH IN PROSTATE CANCER CELLS

1999 ◽  
Vol 161 (2) ◽  
pp. 674-679 ◽  
Author(s):  
MAKOTO SUMITOMO ◽  
MASAAKI TACHIBANA ◽  
JUN NAKASHIMA ◽  
MASARU MURAI ◽  
AKIRA MIYAJIMA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Essential Role ◽  
Nuclear Factor Kappa B ◽  
Tnf Alpha ◽  
Nuclear Factor ◽  
Prostate Cancer Cells ◽  
Nuclear Factor Kappa

scholarly journals SAGE components enhance cell death through nuclear factor kappa-B signaling

10.2741/e256 ◽  
2011 ◽  
Vol E3 (2) ◽  
pp. 410-420 ◽  
Author(s):  
Hala Uthman Gali-Muhtasib
Keyword(s):  
Cell Death ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa
Sign in / Sign up

Export Citation Format

Share Document