scholarly journals The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral cores

2019 ◽  
Vol 27 (3) ◽  
pp. 535-543 ◽  
Author(s):  
N.L.A. Fell ◽  
B.M. Lawless ◽  
S.C. Cox ◽  
M.E. Cooke ◽  
N.M. Eisenstein ◽  
...  
2014 ◽  
Vol 7 (5) ◽  
pp. 377-386 ◽  
Author(s):  
Stephen A. Brigido ◽  
Nicole M. Protzman ◽  
Melissa M. Galli ◽  
Scott T. Bleazey

Cystic talar shoulder defects are particularly challenging osteochondral lesions. A retrospective chart review was performed on 13 adults that previously failed microfracture, presented with medial cystic osteochondral lesions of the talus, and were treated with malleolar osteotomy and subchondral allograft reconstruction. The aim of the study was to evaluate the effect of a medial malleolar osteotomy and allograft subchondral bone plug on pain and function. We hypothesized that following surgery, pain and function would significantly improve. Compared with preoperative measures, pain (first step in the morning, during walking, at the end of the day) and function (descending the stairs, ascending the stairs, and ambulating up to 4 blocks) improved postoperatively at 6 and 12 months ( P ≤ .001). During each activity, pain improved postoperatively from 6 to 12 months ( P ≤ .006). Postoperatively, from 6 to 12 months, the level of disability improved while descending the stairs ( P = .004), and the level of disability experienced while ascending the stairs and ambulating up to 4 blocks was maintained ( P ≥ .02). Multiple regression analyses identified body mass index as a predictor of preoperative function ( R2 = .34, P = .04). No variables were identified as significant predictors of postoperative pain or function. With all osteotomies healing, no graft rejection, and a single deep venous thrombosis, allograft subchondral plugs appear to successfully treat osteochondral lesions of the talus with improvements in pain and function as well as an acceptable complication rate. Level of Evidence: Therapeutic, Level IV: Retrospective Case Series.


2017 ◽  
Vol 25 (12) ◽  
pp. 2108-2118 ◽  
Author(s):  
O.O. Adebayo ◽  
F.C. Ko ◽  
P.T. Wan ◽  
S.R. Goldring ◽  
M.B. Goldring ◽  
...  

2016 ◽  
Vol 1383 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Thomas R. Coughlin ◽  
Oran D. Kennedy

2018 ◽  
Vol 26 ◽  
pp. S118
Author(s):  
P. Chan ◽  
M. Au ◽  
W. Yang ◽  
C. Yan ◽  
K. Chiu ◽  
...  

Bone Research ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yan Hu ◽  
Xiao Chen ◽  
Sicheng Wang ◽  
Yingying Jing ◽  
Jiacan Su

AbstractOsteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain, causing disability and economic burden. The incidence of osteoarthritis is rapidly increasing worldwide due to aging and obesity trends. Basic and clinical research on osteoarthritis has been carried out for decades, but many questions remain unanswered. The exact role of subchondral bone during the initiation and progression osteoarthritis remains unclear. Accumulating evidence shows that subchondral bone lesions, including bone marrow edema and angiogenesis, develop earlier than cartilage degeneration. Clinical interventions targeting subchondral bone have shown therapeutic potential, while others targeting cartilage have yielded disappointing results. Abnormal subchondral bone remodeling, angiogenesis and sensory nerve innervation contribute directly or indirectly to cartilage destruction and pain. This review is about bone-cartilage crosstalk, the subchondral microenvironment and the critical role of both in osteoarthritis progression. It also provides an update on the pathogenesis of and interventions for osteoarthritis and future research targeting subchondral bone.


2007 ◽  
pp. 15-32 ◽  
Author(s):  
Johanne Martel-Pelletier ◽  
Daniel Lajeunesse ◽  
Pascal Reboul ◽  
Jean-Pierre Pelletier
Keyword(s):  

2015 ◽  
Vol 48 (2) ◽  
pp. 228-233 ◽  
Author(s):  
E. Bani Hassan ◽  
M. Mirams ◽  
A. Ghasem-Zadeh ◽  
E. J. Mackie ◽  
R. C. Whitton

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