Vitamin D3 Supplementation During Pregnancy and Lactation Improves Vitamin D Status of the Mother–Infant Dyad

Objective: Vitamin D deficiency has been associated with an increased risk of COVID-19 severity. This multi-center randomized clinical trial aims to determine the effects of 5000 IU versus 1000 IU daily oral vitamin D3 supplementation in the recovery of symptoms and other clinical parameters among mild to moderate COVID-19 patients with sub-optimal vitamin D status. Study Design and Setting: A total of 69 reverse transcriptase polymerase chain reaction (RT-PCR) SARS-CoV-2 positive adults who were hospitalized for mild to moderate COVID-19 disease were allocated to receive once daily for 2 weeks either 5000 IU oral vitamin D3 (n = 36, 21 males; 15 females) or 1000 IU oral vitamin D3 (standard control) (n = 33, 13 males; 20 females). Anthropometrics were measured and blood samples were taken pre- and post-supplementation. Fasting blood glucose, lipids, serum 25(OH)D, and inflammatory markers were measured. COVID-19 symptoms were noted on admission and monitored until full recovery. Results: Vitamin D supplementation for 2 weeks caused a significant increase in serum 25(OH)D levels in the 5000 IU group only (adjusted p = 0.003). Within-group comparisons also showed a significant decrease in BMI and IL-6 levels overtime in both groups (p-values < 0.05) but was not clinically significant in between-group comparisons. Kaplan–Meier survival analysis revealed that the 5000 IU group had a significantly shorter time to recovery (days) than the 1000 IU group in resolving cough, even after adjusting for age, sex, baseline BMI, and D-dimer (6.2 ± 0.8 versus 9.1 ± 0.8; p = 0.039), and ageusia (loss of taste) (11.4 ± 1.0 versus 16.9 ± 1.7; p = 0.035). Conclusion: A 5000 IU daily oral vitamin D3 supplementation for 2 weeks reduces the time to recovery for cough and gustatory sensory loss among patients with sub-optimal vitamin D status and mild to moderate COVID-19 symptoms. The use of 5000 IU vitamin D3 as an adjuvant therapy for COVID-19 patients with suboptimal vitamin D status, even for a short duration, is recommended.

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Effects of one year high vs low dose oral vitamin D3 supplementation on the vitamin D status in 100 patients with postmenopausal osteoporosis

Bone ◽

10.1016/j.bone.2011.03.498 ◽

2011 ◽

Vol 48 ◽

pp. S216

Author(s):

D. Grigorie⁎ ◽

A. Sucaliuc ◽

E. Neacsu ◽

M. Ivan ◽

A. Diaconescu ◽

...

Keyword(s):

Vitamin D ◽

Postmenopausal Osteoporosis ◽

Vitamin D3 ◽

Low Dose ◽

Vitamin D Status ◽

Oral Vitamin ◽

Dose Oral ◽

Vitamin D3 Supplementation ◽

One Year

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A Review of the Effect of Vitamin D3 Supplementation on Insulin Response in Adults With Overweight or Obesity

Current Developments in Nutrition ◽

10.1093/cdn/nzab059_013 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 1312-1312

Author(s):

Kimberly Gaskill ◽

Madeline Bartzis ◽

Annalyse Boucher ◽

Kristin Lawton ◽

Rex Liang ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Insulin Sensitivity ◽

Lifestyle Intervention ◽

Vitamin D3 ◽

Insulin Response ◽

Inverse Association ◽

Vitamin D Status ◽

Vitamin D3 Supplementation ◽

Overweight Or Obesity

Abstract Objectives There is an inverse association between serum vitamin D and excess body weight, insulin resistance, β-cell dysfunction, and the risk of developing type 2 diabetes (T2DM). Given that inadequate vitamin D is common in adults with overweight or obesity, vitamin D supplementation may improve insulin response. The aim of this review was to investigate whether vitamin D3 supplementation in excess of the Recommended Daily Allowance (RDA: 600 IU/day) improves insulin sensitivity or reduces insulin resistance in adults with overweight or obesity and no prior diagnosis of T2DM. Methods A literature search was conducted using PubMed and CINAHL with the following search terms: ((vitamin D OR cholecalciferol supplement*) AND (overweight OR obes*) AND (insulin resistance OR insulin sensitivity)). The initial search generated 806 unduplicated articles. Filters and exclusions were applied; 171 articles were screened, 40 were reviewed in full-text and 5 randomized control trials published between 2015–2020 met inclusion criteria for the review. Results In all five studies, vitamin D3 supplementation in excess of the RDA for ≥3 months corrected vitamin D status, with no adverse effects, among the majority of subjects. Two studies provided a lifestyle intervention in addition to vitamin D3 at 25,000 and 50,000 IU/week for ≥3 months and significantly (p < 0.001 and p = 0.04 respectively) improved insulin sensitivity in adults with overweight or obesity and vitamin D deficiency. However, no significant effects on insulin response were observed in the other three studies. Conclusions High-dose vitamin D3 was effective in repleting vitamin D status in adults with overweight or obesity and inadequate vitamin D levels, and should be recommended per Endocrine Society clinical practice guidelines. Furthermore, vitamin D3 supplementation in excess of the RDA for ≥3 months combined with a lifestyle intervention may have a beneficial effect on insulin response in adults who are at risk for T2DM. Funding Sources None.

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MP31-15 SERUM VITAMIN D STATUS, VITAMIN D3 SUPPLEMENTATION AND URINE CALCIUM LEVELS AMONG 140 CALCIUM KIDNEY STONE PATIENTS

The Journal of Urology ◽

10.1016/j.juro.2018.02.1044 ◽

2018 ◽

Vol 199 (4S) ◽

Author(s):

Barry S. Farber, M.D. ◽

Robert E. Kennedy, Jr., Ph. D.

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Kidney Stone ◽

Serum Vitamin ◽

Vitamin D Status ◽

Urine Calcium ◽

Serum Vitamin D ◽

Vitamin D3 Supplementation

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The Effects of Cholecalciferol Supplementation on Vitamin D Status Among a Diverse Population of Collegiate Basketball Athletes: A Quasi-Experimental Trial

Nutrients ◽

10.3390/nu12020370 ◽

2020 ◽

Vol 12 (2) ◽

pp. 370 ◽

Cited By ~ 2

Author(s):

Nicole M. Sekel ◽

Sina Gallo ◽

Jennifer Fields ◽

Andrew R. Jagim ◽

Tammy Wagner ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Injury Risk ◽

Collegiate Athletes ◽

Vitamin D Status ◽

Experimental Trial ◽

Quasi Experimental ◽

Vitamin D3 Supplementation ◽

Collegiate Basketball ◽

Cholecalciferol Supplementation

Vitamin D may play a role in performance and injury risk, yet the required supplementation dosage for collegiate athletes is unclear. The objective of this study was to define the dosage of vitamin D3 supplementation required to beneficially affect serum 25-hydroxyvitamin D (25(OH)D) among a sample of collegiate basketball athletes. This was a quasi-experimental trial, participants were allocated to one of three groups of vitamin D3 daily at the beginning of pre-season training and dependent upon their baseline vitamin D status as follows: insufficient (<75 nmol/L) to 10,000 IU, sufficient (75–125 nmol/L) to 5000 IU and optimal (>125 nmol/L) to no supplementation. Follow-up assessments were completed ~ 5 months later in post season. The majority (n = 13) were allocated to 10,000 IU vs. n = 5 to 5000 IU and n = 2 to no supplementation. The 10,000 IU group showed the greatest change (35.0 ± 27.0 nmol/L) vs. the 5000 IU group (−9.3 ± 9.6 nmol/L) and no supplementation group (−41.6 ± 11.7 nmol/L, p < 0.01). Only 1 participant reached optimal status in the 10,000 IU group. In conclusion, a daily dosage of 10,000 IU vitamin D3 supplementation mitigated the high prevalence of vitamin D deficiency among collegiate basketball players but was insufficient for all to reach sufficient levels.

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