Spectrophotometric method development and validation for atorvastatin calcium and nifedipine HCl in bulk and tablet dosage form using absorption ratio method assay of atorvastatin and nifedipine

2013 ◽  
Vol 7 (7) ◽  
pp. 666-669
Author(s):  
Sathis Kumar Dinakaran ◽  
Babitha Alluri ◽  
Koushik Reddy Annareddy ◽  
VijayaSravani Ayyagari ◽  
Harani Avasarala ◽  
...  
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Method Development ◽  
Ratio Method ◽  
Atorvastatin Calcium ◽  
Absorption Ratio ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Tablet Dosage

UV Spectrophotometric Method Development and Validation of Carbimazole in Bulk and Tablet Dosage form

2021 ◽  
pp. 163-166
Author(s):  
Zainab A. Bagalkote ◽  
Ganesh Gajeli
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Method Development ◽  
Uv Spectrum ◽  
Highly Sensitive ◽  
Method Development And Validation ◽  
Uv Visible ◽  
Development And Validation ◽  
Tablet Dosage ◽  
The Given

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the estimation of Carbimazole in Tablet dosage form. Methods: The UV spectrum of Carbimazole in methanol and distilled water (30:70) showed λ max at 289.6nm. Beer’s law is valid in the concentration range of 10-50µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 10-50µg/ml with the regression equation y = 0.0232x + 0.0466, and regression coefficient i.e, r2= 0.9992 moreover, the method was found to be highly sensitive with LOD (1.818µg/ml) and LOQ (5.509µg/ml). Conclusion: From the results it can be concluded that the given method can be successfully applied for assay of Carbimazole in Tablet dosage form.

scholarly journals UV VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF DASATINIB IN BULK AND SOLID DOSAGE FORM

2020 ◽  
pp. 90-93
Author(s):  
SAILI MADUR ◽  
VINOD MATOLE ◽  
MALLINATH KALSHETTI
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Method Development ◽  
Uv Spectrum ◽  
Solid Dosage ◽  
Highly Sensitive ◽  
Method Development And Validation ◽  
Uv Visible ◽  
Development And Validation ◽  
Tablet Dosage

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Dasatinib in Tablet dosage form with­­­ methanol. Methods: The method is based on the formation of a colorlesscomplex. The UV spectrum of Dasatinib in methanol showed maximum wavelength at 248 nm. Beer’s law is valid in the concentration range of 7-35µg/ml. this method was validated for linearity, accuracy, precision, assay, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 7-35µg/ml with the regression equation y = 0.0332x+0.0633 and regression coefficient i.e. r2= 0.9994moreover, the method was found to be highly sensitive with LOD(1.08µg/ml) and LOQ(3.29µg/ml). Conclusion: Based on the results the proposed method can be successfully applied for the assay of Dasatinib in various tablet dosage forms.

UV Spectrophotometric Method Development and Validation of Darunavir in bulk and Solid Dosage Form

2021 ◽  
pp. 3262-3264
Author(s):  
Varsha Tegeli ◽  
Avinash Birajdar ◽  
Vinod Matole
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Method Development ◽  
Uv Spectrum ◽  
Solid Dosage ◽  
Highly Sensitive ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Tablet Dosage

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Darunavir in Tablet dosage form with¬¬¬ 0.1N HCl. Method: The method is based on the formation of a colorless complex. The UV spectrum of Darunavir in 0.1N HCl showed maximum wavelength at 298nm. Beer’s law is valid in the concentration range of 10-60µg/ml. this method was validated for linearity, accuracy, precision, assay, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 10-60µg/ml with the regression equation y=0.0113x+0.0098, and regression coefficient i.e. r2=0.9992 moreover, the method was found to be highly sensitive with LOD (1.85µg/ml) and LOQ (5.62µg/ml). Conclusion: Based on the results the proposed method can be successfully applied for the assay of Darunavir in various tablet dosage forms.

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