Is Medication Related Osteonecrosis of the Jaw around implants a rare entity ? A case series with a focus on etiopathophysiology

2021 ◽  
Author(s):  
Jean Massaad ◽  
Michèle Magremanne
Keyword(s):  
Case Series ◽  
Osteonecrosis Of The Jaw ◽  
Rare Entity

scholarly journals Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series

2021 ◽  
Vol 18 (3) ◽  
pp. 1018
Author(s):  
Guillermo Pardo-Zamora ◽  
Yanet Martínez ◽  
Jose Antonio Moreno ◽  
Antonio J. Ortiz-Ruíz
Keyword(s):  
Bone Structure ◽  
Negative Impact ◽  
Maxillofacial Surgery ◽  
Case Series ◽  
Osteonecrosis Of The Jaw ◽  
Oral And Maxillofacial Surgery ◽  
Minimally Invasive Surgical ◽  
Therapeutic Protocols ◽  
Serious Disease ◽  
The University

Medication-induced jaw osteonecrosis (MRONJ) is a rare and serious disease with a negative impact on patients’ quality of life, whose exact cause remains unclear and which may have a multifactorial origin. Although there are different therapeutic protocols, there is still no consensus. This case series evaluated three patients diagnosed with staged 2 MRONJ treated at the University of Murcia dental clinic according to the protocols described by the Spanish Society of Oral and Maxillofacial Surgery and the American Association of Oral and Maxillofacial Surgeons. Within 12 months of the application of therapeutic protocols, the lesions were completely healed in all cases. Radiography showed slow but progressive healing with normal bone structure. Conservative treatment with antibiotics, chlorhexidine rinses and minimally invasive surgical intervention with necrotic bone resection is effective in treating stage 2 of MRONJ. In cases of refractory osteonecrosis, the application of platelet and leukocyte-rich fibrin (PRF-L) in the surgical approach improves the outcome in soft tissue healing and bone regeneration but further research is needed to confirm its effectiveness.

scholarly journals Medication-Related Osteonecrosis of the Jaw (MRONJ): Are Antiresorptive Drugs the Main Culprits or Only Accomplices? The Triggering Role of Vitamin D Deficiency

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 561
Author(s):  
Luca Dalle Carbonare ◽  
Monica Mottes ◽  
Maria Teresa Valenti
Keyword(s):  
Vitamin D ◽  
Clinical Condition ◽  
Case Series ◽  
Osteonecrosis Of The Jaw ◽  
First Case ◽  
Vitamin D Levels ◽  
Exposed Bone ◽  
Antiresorptive Drugs ◽  
Almost All

Osteonecrosis of the jaw (ONJ) is a severe clinical condition characterized mostly but not exclusively by an area of exposed bone in the mandible and/or maxilla that typically does not heal over a period of 6–8 weeks. The diagnosis is first of all clinical, but an imaging feedback such as Magnetic Resonance is essential to confirm clinical suspicions. In the last few decades, medication-related osteonecrosis of the jaw (MRONJ) has been widely discussed. From the first case reported in 2003, many case series and reviews have appeared in the scientific literature. Almost all papers concerning this topic conclude that bisphosphonates (BPs) can induce this severe clinical condition, particularly in cancer patients. Nevertheless, the exact mechanism by which amino-BPs would be responsible for ONJ is still debatable. Recent findings suggest a possible alternative explanation for BPs role in this pattern. In the present work we discuss how a condition of osteomalacia and low vitamin D levels might be determinant factors.

scholarly journals Endodontic management of multiple roots and root canals in mandibular canine: A case report series

2021 ◽  
Vol 6 (3) ◽  
pp. 166-170
Author(s):  
Pradeep Nivas Varatharajan ◽  
Manoj kumar thirunavukkarasu ◽  
Athul Babu Kurian ◽  
K. Madhuram
Keyword(s):  
Case Series ◽  
Endodontic Treatment ◽  
Rare Entity ◽  
Internal Anatomy ◽  
Root Canals ◽  
Single Root ◽  
Precise Knowledge ◽  
Mandibular Canine

Successful endodontic treatment depends upon the clinician’s precise knowledge and ability to manage complex internal anatomy in order to avoid failure during endodontic treatment. Mandibular canines normally have single root with centrally placed single canal and internal anatomy as simple as could be expected, but there are such canines with a single root with two canals, two roots or fused roots. The occurrence of two canal joining to one for a men may be a rare entity with 4-15% prevalence. Canine is the cornerstone of mouth due to its position and very important as abutment for any type of restoration, so long term success of the restorative depend directly on the quality of endodontic treatment. This article presents a case series of successful endodontic management of mandibular canine with two canals which merge into one canal with one foramina and mandibular canine with two roots and two canals.

scholarly journals Nonexposed Variant of Bisphosphonate-associated Osteonecrosis of the Jaw: A Case Series

2010 ◽  
Vol 123 (11) ◽  
pp. 1060-1064 ◽  
Author(s):  
Stefano Fedele ◽  
Stephen R. Porter ◽  
Francesco D'Aiuto ◽  
Suad Aljohani ◽  
Paolo Vescovi ◽  
...  
Keyword(s):  
Case Series ◽  
Osteonecrosis Of The Jaw

Parathyroid Carcinoma, a Rare Entity with Varying Presentation and Treatment

2010 ◽  
Vol 2 (1) ◽  
pp. 33-36
Author(s):  
Ronald W Ter Haar ◽  
Gerlof D Valk ◽  
Inne HM Borel Rinkes ◽  
Menno R Vriens
Keyword(s):  
Parathyroid Carcinoma ◽  
Case Series ◽  
Diagnostic Approach ◽  
Rare Entity ◽  
Parathyroid Cancer ◽  
Operative Strategy ◽  
Parathyroid Lesion

ABSTRACT Background Parathyroid carcinoma is a rare entity that has diverse presentation and diverse treatments. This case-series highlights the atypical and diverse presentation of parathyroid carcinoma and stresses the importance of the diagnostic approach and intraoperative strategy. Methods We report three patients with parathyroid cancer. Results In one patient, a parathyroid lesion was found to be a parathyroid carcinoma intraoperatively, resulting in a change of operative strategy. In another, parathyroid carcinoma was suspected preoperatively and was treated accordingly. A third patient presented with an already a metastasized parathyroid carcinoma. Conclusion The diagnostic approach and intraoperative strategy are instrumental to determining the best treatment and yielding the best outcome.

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