(405) Lower-dose diclofenac capsules using SoluMatrix fine particle technology provide effective pain relief in a phase 3 study of patients with acute pain following bunionectomy

2014 ◽  
Vol 15 (4) ◽  
pp. S77 ◽  
Author(s):  
S. Daniels ◽  
D. Solorio ◽  
C. Young
Keyword(s):  
Pain Relief ◽  
Acute Pain ◽  
Fine Particle ◽  
Phase 3 ◽  
Particle Technology ◽  
Effective Pain Relief

scholarly journals The simple query “Do you want more pain medication?” is not a reliable way to assess acute pain relief in patients in the emergency department

CJEM ◽  
2017 ◽  
Vol 20 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Jean-Marc Chauny ◽  
Martin Marquis ◽  
Jean Paquet ◽  
Gilles Lavigne ◽  
Alexis Cournoyer ◽  
...  
Keyword(s):  
Emergency Department ◽  
Cohort Study ◽  
Pain Relief ◽  
Acute Pain ◽  
Pain Medication ◽  
Accurate Assessment ◽  
Pain Level ◽  
Pain Problem ◽  
Effective Pain Relief ◽  
Simple Query

AbstractObjectiveThe management of acute pain constitutes an essential skill of emergency department (ED) physicians. However, the accurate assessment of pain intensity and relief represents a clinically challenging undertaking. Some studies have proposed to define effective pain relief as the patient’s refusal for additional analgesic administration. The aim of this study was to verify whether such a refusal is effectively indicative of pain relief.MethodsThis prospective cohort study included ED patients who received single or multiple doses of pain medication for an acute pain problem. Patients were evaluated for pain relief using one Likert scale and two dichotomous questions: Is your pain relieved? and Do you want more analgesics? Non-relieved patients were further analysed using a checklist as to the reasons behind their refusal for supplemental pain medication.ResultsWe have recruited 378 adult patients with a mean age of 50.3 years (±19.1); 60% were women and had an initial mean pain level of 7.3 (±2.0) out of 10. We observed that 68 out of 244 patients who were adequately relieved from pain asked for more analgesics (28%), whereas 51 out of 134 patients who were not relieved from pain refused supplemental drugs (38%). Reasons for refusal included wanting to avoid side effects, feeling sufficiently relieved, and disliking the medication’s effects.ConclusionOver a third of ED patients in acute pain were not relieved but refused supplemental pain medication. Patients have reported legitimate reasons to decline further analgesics, and this refusal cannot be used as an indication of pain relief.

scholarly journals Administration of Nebulized Ketamine for Managing Acute Pain in the Emergency Department: A Case Series

2020 ◽  
Vol 4 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Jefferson Drapkin ◽  
Aidin Masoudi ◽  
Mahlaqa Butt ◽  
Rukhsana Hossain ◽  
Antonios Likourezos ◽  
...  
Keyword(s):  
Emergency Department ◽  
Chronic Pain ◽  
Pain Relief ◽  
Acute Pain ◽  
Case Series ◽  
Effective Pain Relief

Ketamine administration in sub-dissociative doses in the emergency department (ED) results in effective pain relief in patients with acute traumatic and non-traumatic pain, chronic pain, and opioid-tolerant pain. This case series describes five adult ED patients who received nebulized ketamine for predominantly acute traumatic pain. Three patients received nebulized ketamine at 1.5 milligrams per kilogram (mg /kg) dose, one patient at 0.75 mg/kg, and one patient at 1 mg/kg. All five patients experienced a decrease in pain from the baseline up to 120 minutes. The inhalation route of ketamine delivery via breath-actuated nebulizer may have utility for managing pain in the ED.

scholarly journals Diclofenac submicron particle capsules demonstrate early and sustained acute pain relief in a phase 3 study in patients following bunionectomy surgery

2013 ◽  
Vol 21 ◽  
pp. S291 ◽  
Author(s):  
C. Argoff ◽  
S. Silberstein ◽  
A. Gibofsky ◽  
S. Daniels ◽  
S. Jensen ◽  
...  
Keyword(s):  
Pain Relief ◽  
Acute Pain ◽  
Submicron Particle ◽  
Phase 3

scholarly journals Applying a Sensing-Enabled System for Ensuring Safe Anterior Cingulate Deep Brain Stimulation for Pain

2019 ◽  
Vol 9 (7) ◽  
pp. 150 ◽  
Author(s):  
Yongzhi Huang ◽  
Binith Cheeran ◽  
Alexander L. Green ◽  
Timothy J. Denison ◽  
Tipu Z. Aziz
Keyword(s):  
Deep Brain Stimulation ◽  
Pain Relief ◽  
Brain Stimulation ◽  
Brain Activity ◽  
Anterior Cingulate ◽  
Chronic Therapy ◽  
Provide Pain Relief ◽  
Surgical Options ◽  
Effective Pain Relief ◽  
Deep Brain

Deep brain stimulation (DBS) of the anterior cingulate cortex (ACC) was offered to chronic pain patients who had exhausted medical and surgical options. However, several patients developed recurrent seizures. This work was conducted to assess the effect of ACC stimulation on the brain activity and to guide safe DBS programming. A sensing-enabled neurostimulator (Activa PC + S) allowing wireless recording through the stimulating electrodes was chronically implanted in three patients. Stimulation patterns with different amplitude levels and variable ramping rates were tested to investigate whether these patterns could provide pain relief without triggering after-discharges (ADs) within local field potentials (LFPs) recorded in the ACC. In the absence of ramping, AD activity was detected following stimulation at amplitude levels below those used in chronic therapy. Adjustment of stimulus cycling patterns, by slowly ramping on/off (8-s ramp duration), was able to prevent ADs at higher amplitude levels while maintaining effective pain relief. The absence of AD activity confirmed from the implant was correlated with the absence of clinical seizures. We propose that AD activity in the ACC could be a biomarker for the likelihood of seizures in these patients, and the application of sensing-enabled techniques has the potential to advance safer brain stimulation therapies, especially in novel targets.

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