High-throughput determination of ultra-low concentrations of LAG078, a lipid modulator, in human plasma

2005 ◽  
Vol 37 (5) ◽  
pp. 1039-1048
Author(s):  
Tapan K. Majumdar ◽  
Ray Bakhtiar ◽  
Cindy Chen ◽  
Luis Ramos ◽  
Francis L.S. Tse
Keyword(s):  
Human Plasma ◽  
High Throughput ◽  
Low Concentrations

Fluorometric method for phenylalanine microplate assay adapted for phenylketonuria screening.

1989 ◽  
Vol 35 (10) ◽  
pp. 2112-2115 ◽  
Author(s):  
N S Gerasimova ◽  
I V Steklova ◽  
T Tuuminen
Keyword(s):  
Amino Acid ◽  
Human Plasma ◽  
High Throughput ◽  
Microplate Assay ◽  
Fluorometric Method ◽  
Amino Acid Analyzer ◽  
Screening Sensitivity ◽  
Blood Spot ◽  
Plasma Assay

Abstract We adapted the method of McCaman and Robins for fluorometry of phenylalanine to a microplate assay for routine phenylketonuria screening. Sensitivity is 15 mumol/L for the plasma assay and 30 mumol/L for the dried blood-spot assay, with CV less than 10% for both assays. Results for human plasma by microplate assay correlated well (r = 0.99) with results of amino acid analyzer determination of phenylalanine. When measurements are performed in an automated reader, the microplate assay has considerable advantages over conventional measurements in cuvettes: smaller volumes of reagents and automation enabling high throughput and convenience. Because the described method is a quantitative one, we can postulate that, compared with the semiquantitative Guthrie inhibition bioassay, this microplate assay is more reliable, easier to perform, and about twofold less costly.

High-throughput solid-phase extraction for the determination of cimetidine in human plasma

1998 ◽  
Vol 714 (2) ◽  
pp. 361-368 ◽  
Author(s):  
J Hempenius ◽  
J Wieling ◽  
J.P.G Brakenhoff ◽  
F.A Maris ◽  
J.H.G Jonkman
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
High Throughput ◽  
Solid Phase ◽  
Phase Extraction

High throughput LC–MS/MS method for simultaneous determination of zidovudine, lamivudine and nevirapine in human plasma

2013 ◽  
Vol 921-922 ◽  
pp. 9-14 ◽  
Author(s):  
Valluru Rajani Kumar ◽  
B. Phani Bhushana Reddy ◽  
B. Ravi Kumar ◽  
K. Sreekanth ◽  
Kilaru Naveen Babu
Keyword(s):  
Simultaneous Determination ◽  
Human Plasma ◽  
High Throughput

High-throughput CZE-UV determination of arginine and dimethylated arginines in human plasma

2007 ◽  
Vol 28 (12) ◽  
pp. 1942-1948 ◽  
Author(s):  
Angelo Zinellu ◽  
Salvatore Sotgia ◽  
Elisabetta Zinellu ◽  
Antonio Pinna ◽  
Francesco Carta ◽  
...  
Keyword(s):  
Human Plasma ◽  
High Throughput
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