Structure elucidation and quantification of impurities formed between 6-aminocaproic acid and the excipients citric acid and sorbitol in an oral solution using high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy

2015 ◽  
Vol 107 ◽  
pp. 333-340 ◽  
Author(s):  
Anne Marie V. Schou-Pedersen ◽  
Claus Cornett ◽  
Nils Nyberg ◽  
Jesper Østergaard ◽  
Steen Honoré Hansen
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Citric Acid ◽  
High Resolution ◽  
Structure Elucidation ◽  
High Resolution Mass Spectrometry ◽  
Aminocaproic Acid ◽  
Oral Solution ◽  
Resonance Spectroscopy ◽  
Resolution Mass

scholarly journals Five New Ent-Atisene Glycosides From Stevia rebaudiana

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1986265
Author(s):  
Krishna P. Devkota ◽  
Romila D. Charan ◽  
Christopher Priedemann ◽  
Ryan Donovan ◽  
Tara M. Snyder ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Magnetic Resonance Spectroscopy ◽  
High Resolution Mass Spectrometry ◽  
Stevia Rebaudiana ◽  
Resonance Spectroscopy ◽  
Stevia Rebaudiana Bertoni ◽  
Resolution Mass

Five new ent-atisene diterpene glycosides (1-5) have been isolated from Stevia rebaudiana Bertoni. This adds to a list of only 2 new ent-atisene diterpene glycosides isolated previously from S. rebaudiana. Diterpene glycosides isolated from S. rebaudiana, such as the rebaudiosides, are typically associated with the ent-kaurene core and glycosylation at the C-13 and C-19 positions. Extensive application of nuclear magnetic resonance spectroscopy techniques (1H, 13C, 1D-TOCSY, COSY, HSQC-DEPT, HMBC, and ROESY) as well as high-resolution mass spectrometry demonstrated that the ent-atisenes 1 to 5 had glycosylation patterns identical to rebaudiosides J, N, O, K, and T, respectively. We have named these compounds stevatisene J, N, O, K, and T, respectively.

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